This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abbexa
product type :
antibody
product name :
Large Tumor Suppressor Kinase 1 (LATS1) Antibody
catalog :
abx033135
quantity :
80 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry
product information
Catalogue Code :
abx033135
Target :
Large Tumor Suppressor Kinase 1 (LATS1)
Product Name :
Large Tumor Suppressor Kinase 1 (LATS1) Antibody
Short Name :
LATS1
Category :
Primary Antibodies
Host :
Rabbit
Clonality :
Polyclonal
Conjugation :
Unconjugated
Isotype :
IgG
Size 1 :
80 µl
Size 2 :
400 µl
Description :
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
UniProt Primary AC :
O95835
UniProt Entry Name :
LATS1_HUMAN
NCBI Accession :
NP_001257448.1, NP_004681.1
KEGG :
hsa:9113
String :
9606.ENSP00000437550
Purification :
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Buffer :
PBS containing 0.09% sodium azide.
Tested Applications :
ELISA, WB, IHC
Storage :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Form :
Liquid
UNSPSC Code :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
company information
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
headquarters: UK
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.