This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abbexa
product type :
antibody
product name :
Sonic Hedgehog Protein (SHH) Antibody
catalog :
abx015984
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human, mouse, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, flow cytometry
product information
Catalogue Code :
abx015984
Target :
Sonic Hedgehog Protein (SHH)
Product Name :
Sonic Hedgehog Protein (SHH) Antibody
Short Name :
SHH
Category :
Primary Antibodies
Host :
Mouse
Clonality :
Monoclonal
Conjugation :
Unconjugated
Isotype :
IgG1
Size 1 :
100 µl
Description :
This gene encodes a protein that is instrumental in patterning the early embryo.It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites.Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar.The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing.More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres.HPE is manifested by facial deformities.It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
Purification :
Purified from ascites by Protein G chromatography.
Buffer :
PBS, containing 0.05% sodium azide.
Concentration :
1 mg/ml
Tested Applications :
ELISA, WB, IHC, FCM
Storage :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Form :
Liquid
UNSPSC Code :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
company information
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
headquarters: UK
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.