This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abbexa
product type :
antibody
product name :
T-lymphocyte activation antigen CD80 / B7-1 (CD80) Antibody
catalog :
abx015727
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human, mouse, domestic rabbit
application :
immunohistochemistry, immunocytochemistry
product information
Catalogue Code :
abx015727
Target :
T-lymphocyte activation antigen CD80 / B7-1 (CD80)
Product Name :
T-lymphocyte activation antigen CD80 / B7-1 (CD80) Antibody
Short Name :
CD80
Category :
Primary Antibodies
Host :
Mouse
Clonality :
Monoclonal
Conjugation :
Unconjugated
Isotype :
IgG1
Size 1 :
100 µl
Description :
The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival.It is also known as B7.1.Its principal mode of action is by binding to CD28.Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells.CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells.Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells.Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions.In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation.""When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss."" In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans.Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body.Osteoclast differentiation is inhibited by osteoprotegerin; Estrogen stimulates osteoprotegerin production.
Purification :
Unpurified ascites.
Buffer :
Ascitic fluid containing 0.03% sodium azide.
Concentration :
Not determined
Tested Applications :
ELISA, IHC, IF/ICC
Storage :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Form :
Liquid
UNSPSC Code :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
company information
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
headquarters: UK
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.