This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abbexa
product type :
antibody
product name :
Tumor Necrosis Factor Receptor 1 (TNFR1) Antibody
catalog :
abx012259
quantity :
100 µg
price :
565.5 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
immunohistochemistry
product information
Catalog Number :
abx012259
Target :
TNFR1
Product Name :
Tumor Necrosis Factor Receptor 1 (TNFR1) Antibody
Short Name :
TNFR1
Product Type :
Primary Antibodies
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugation :
Unconjugated
Size 1 :
100 µg
Price 1 (USD) :
565.5 USD
Product Description :
TNFR1 Antibody detects endogenous levels of TNFR1. TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD.
UniProt Primary AC :
P19438
UniProt Entry Name :
TNR1A_HUMAN
Gene Symbol :
TNFRSF1A
OMIM :
142680
HGNC :
11916
KEGG :
hsa:7132
Ensembl :
ENSG00000067182
String :
9606.ENSP00000162749
CrossReactivity :
Human, Mouse, Rat
Purification :
Purified by affinity chromatography.
Buffer :
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications :
IHC
Storage :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UNSPSC Code :
12352203
Availability :
Shipped within 5-10 working days.
Note :
This product is for research use only.
Dry Ice :
No
company information
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
headquarters: UK
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.