This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abbexa
product type :
antibody
product name :
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody
catalog :
abx010442
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry
product information
Catalogue Code :
abx010442
Target :
Serine/threonine-Protein Kinase B-Raf (BRAF)
Product Name :
Serine/threonine-Protein Kinase B-Raf (BRAF) Antibody
Short Name :
BRAF
Category :
Primary Antibodies
Host :
Mouse
Clonality :
Monoclonal
Conjugation :
Unconjugated
Isotype :
IgG1
Size 1 :
100 µl
Description :
B-Raf is a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.
UniProt Primary AC :
P15056
UniProt Entry Name :
BRAF_HUMAN
Gene Symbol :
BRAF
OMIM :
114500
HGNC :
1097
KEGG :
hsa:673
Ensembl :
ENSG00000157764
String :
9606.ENSP00000288602
Purification :
Unpurified ascites.
Buffer :
Ascitic fluid containing 0.03% sodium azide.
Concentration :
Not determined
Tested Applications :
ELISA, IHC
Storage :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Form :
Liquid
UNSPSC Code :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
company information
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
headquarters: UK
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.