protein

Recombinant human DKK1 protein

ATGP0269

10 ug

160 USD

Recombinant human DKK1 protein

32-266aa

ATGP0269

NP_036374

Dickkopf-related protein 1, also known as Dkk-1, is a member of the Dkk protein family including Dkk-1, 2, 3 and -4. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated level of Dkk-1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Recombinant human Dkk-1 protein, fused to His-tag at C-terminus, was expressed ininsect cell using baculovirus expression system and purified by using conventional chromatography.

Dickkopf WNT signaling pathway inhibitor 1, Dickkopf-related protein 1, Dickkopf-1, Dkk-1, SK

0.25mg/ml (determined by Bradford assay)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 50% glycerol, 2mM DTT, 2mM EDTA, 0.1mM PMSF

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Krupnik, V.E. et al. (1999) Gene 238:301-13. ;; Nusse, R. et al. (2001) Nature 411:255-6. ;; Mao, J. et al. (2001) Mol. Cell 7:801-9.;;

> 85% by SDS-PAGE

SDS-PAGE

Human

Signal Transduction

27.8 kDa (253aa)

< 1 EU per 1ug of protein (determined by LAL method)

TLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRHSG RLVPRGS

His-Tag

Baculovirus

Ala

Recombinant Protein

O94907

Dickkopf 1, Dickkopf 1 homolog, Dickkopf 1 like, Dickkopf homolog 1, Dickkopf related protein 1, Dickkopf-1, Dickkopf-related protein 1, Dickkopf-related protein 1 Dickkopf 1, DKK 1, DKK1, DKK-1, hDkk 1, hDkk1, hDkk-1, SK, Xenopus laevis, ATGP0269-10ug, ATGP0269-20ug, ATGP0269-50ug, ATGP0269-100ug, ATGP0269-250ug, ATGP0269-500ug, ATGP0269-1mg, ATGP0269-010, ATGP0269-020, ATGP0269-050, ATGP0269-100, ATGP0269-250, ATGP0269-500, ATGP0269-01M

Hino M, et al. Transforming growth factor-β1 induces invasion ability of HSC-4 human oral squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signalling axis. (J Biochem. 2016){https://pubmed.ncbi.nlm.nih.gov/26861993/}