IL12B antibody (clone AT1D6) | ATGen ATGA0130 product information

product summary

request information :

company name :

ATGen

product type :

antibody

product name :

IL12B antibody (clone AT1D6)

catalog :

ATGA0130

quantity :

100 ul / 50 ul

price :

290 / 170 USD

clonality :

monoclonal

host :

mouse

reactivity :

human, rat

application :

western blot, ELISA

more info or order :

ATGen product webpage

product information

Catalog Number :

ATGA0130

Product Name :

IL12B antibody (clone AT1D6)

Product Type :

Primary Antibody

List Price :

290 / 170 USD

Clonality :

Monoclonal

Host Name :

mouse

Clone :

AT1D6

Conjugate :

unconjugated

Isotype :

IgG1, k

Product Description :

IL-12 is a heterodimer composed of subunits IL-12A p35 and IL-12B p40. Autocrine IL-12 is responsible for the differentiation of naive CD4+T cells into type 1 helper T cells (Th1) that produce interferon-gamma (IFN-gamma). Expression of STAT 4, a signal transduction molecule important in cytokine-induced gene expression, appears central to IL-12 induced Th1 production of IFN-gamma. It also activates production of tumor necrosis factor alpha (TNFalpha) from T and natural killer cells. IL-12 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

CrossReactivity :

Human, Rat

SpeciesSummary :

Human

Background :

unconjugated

Immunogen :

Recombinant human IL12B (23-328aa) purified from E. coli

Purity :

By protein-G affinity chromatography

Packaging :

Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.

PackageSize :

100 ul / 50 ul

Concentration :

1mg/ml

Uses :

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.

Application Summary :

ELISA, WB (Tissue, Cell lysate)

Storage :

Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.

General References :

korman BD, et al., (2008) Curr Allergy Asthma Rep. 8(5):398-403 Holscher C., (2004) Med Microbiol Immunol. 193(1):1-17

more info or order :

ATGen product webpage