This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human YWHAB Protein, GST Tag
catalog :
YWB-H513a
quantity :
100 ug, 1 mg
price :
240 USD, 1200 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
YWB-H513a
product name :
Human YWHAB Protein, GST Tag
quantity :
100 ug, 1 mg
price :
240 USD, 1200 USD
quantity & price :
$240/100ug,$1200/1mg (500ug × 2)
target :
YWHAB
host species :
Human
By Tag :
GST Tag
Research :
For Research Use Only
Source :
Human YWHAB, GST Tag (YWB-H513a) is expressed from E.coli cells. It contains AA Met 1 - Asn 246 (Accession # NP_647539).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>95% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human YWHAB, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Formulation :
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) is also known as 14-3-3 protein beta, GW128, HS1. YWHAB belongs to the 14-3-3 family. YWHAB binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. YWHAB is negative regulator of osteogenesis. YWHAB blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
References :
(1) Liu Y., et al., 2007, Mol. Endocrinol. 21:3050-3061. (2) Jang S.W., et al., 2009, J. Biol. Chem. 284:24512-24525.
company information
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
info@acrobiosystems.com
http://www.acrobiosystems.com
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.