This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human VAP-B Protein, His Tag
catalog :
VAB-H5127
quantity :
100 ug, 1 mg
price :
230 USD, 1200 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
VAB-H5127
product name :
Human VAP-B Protein, His Tag
quantity :
100 ug, 1 mg
price :
230 USD, 1200 USD
quantity & price :
$230/100ug,$1200/1mg
target :
VAP-B
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human VAP-B, His Tag (VAB-H5127) is expressed from E.coli cells. It contains AA Met 1 - Pro 132 (Accession # NP_004729).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>95% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human VAP-B, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Vesicle-associated membrane protein-associated protein B/C (VAPB) is also known as VAMP-associated protein B/C (VAMP-B/VAMP-C or VAP-B/VAP-C), which is a single-pass type IV membrane protein and belongs to the VAMP-associated protein ( VAP ) family. Involved in cellular calcium homeostasis regulation, VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity as well. VAPB can interact with VAMP1 ,VAMP2, HCV NS5A, NS5B ,ZFYVE27 (via MSP domain) and RMDN3. Human VAPB is involved in hepatitis C virus replication through interaction with NS5A and NS5B.
References :
(1) Hamamoto I., et al., 2005, J. Virol. 79:13473-13482. (2) Kanekura K., et al., 2006, J. Biol. Chem. 281:30223-30233. (3) Saita S., et al., 2009, J. Biol. Chem. 284:13766-13777.
company information
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
info@acrobiosystems.com
http://www.acrobiosystems.com
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.