This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human SBDS Protein, His Tag
catalog :
SBS-H5141
quantity :
100 ug, 1 mg
price :
198 USD, 980 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
SBS-H5141
product name :
Human SBDS Protein, His Tag
quantity :
100 ug, 1 mg
price :
198 USD, 980 USD
quantity & price :
$198/100ug,$980/1mg
target :
SBDS
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human SBDS, His Tag (SBS-H5141) is expressed from E.coli cells. It contains AA Ser 2 - Glu 250 (Accession # AAH65700).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>98% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human SBDS, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Shwachman-Bodian-Diamond syndrome protein (SBDS),a member of the SDO1/SBDS family, is also known as ribosome maturation protein SBDS. SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, SBDS triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby SBDS can activate ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is also required for normal levels of protein synthesis. Furthermore, SBDS may play a role in cellular stress resistance.,response to DNA damage and cell proliferation.
References :
(1) Boocock G.R.B., et al., 2003, Nat. Genet. 33:97-101. (2) Austin K.M., et al., 2005, Blood 106:1253-1258. (3) Hesling C., et al., 2007, Exp. Cell Res. 313:4180-4195.
company information
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
info@acrobiosystems.com
http://www.acrobiosystems.com
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.