This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human MIS / AMH Protein, His Tag
catalog :
MIS-H52H5
quantity :
1 mg, 50 ug
price :
2600 USD, 350 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
MIS-H52H5
product name :
Human MIS / AMH Protein, His Tag
quantity :
1 mg, 50 ug
price :
2600 USD, 350 USD
quantity & price :
$350/50ug,$2600/1mg
target :
MIS
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human MIS, His Tag (MIS-H52H5) is expressed from human 293 cells (HEK293). It contains AA Arg 26 - Arg 560 (Accession # P03971-1).
SDS-PAGE Remark(R&NR) :
Human MIS, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than .
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
AMH is a dimeric glycoprotein with a molar mass of 140 kDa. The molecule consists of two identical subunits linked by sulfide bridges, and characterized by the N-terminal dimer (pro-region) and C-terminal dimer. This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. The best-known and most specific effect, mediated through the AMH type II receptors, includes programmed cell death (apoptosis) of the target tissue (the fetal Müllerian ducts). AMH binds to its Type 2 receptor AMHR2, which phosphorylizes a type I receptor under the TGF beta signaling pathwa. AMH works by interacting with specific receptors on the surfaces of the cells of target tissues (anti-Müllerian hormone receptors).
References :
(1) Rzeszowska M, et al. Ginekol Pol. 2016. 87(9):669-674. (2) Hampl R, et al. Physiol Res. 2011. 60(2):217-23. (3) Behringer RR, et al. Curr Top Dev Biol. 1994. 29:171-87.
company information
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
info@acrobiosystems.com
http://www.acrobiosystems.com
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.