This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human Kininogen 1 / KNG1 (LMW) Protein, His Tag
catalog :
KN1-H5225
quantity :
250 ug, 1 mg
price :
250 USD, 800 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
KN1-H5225
product name :
Human Kininogen 1 / KNG1 (LMW) Protein, His Tag
quantity :
250 ug, 1 mg
price :
250 USD, 800 USD
quantity & price :
$250/250ug,$800/1mg (500ug × 2)
target :
Kininogen 1
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human Kininogen 1 (LMW), His Tag (KN1-H5225) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Ser 427 (Accession # P01042-2).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>92% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human Kininogen 1 (LMW), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.
Formulation :
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Kininogen-1 (KNG1) is also known as HMWK, BDK, KNG, is a secreted protein which contains three cystatin domains. KNG1 can be cleaved into the following six chains: Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
References :
(1) Kellermann J., et al., 1986, Eur. J. Biochem. 154:471-478. (2) Wunderer G., et al., 1990, Biol. Chem. Hoppe-Seyler 371:977-981.
company information
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
info@acrobiosystems.com
http://www.acrobiosystems.com
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.