This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human GFR alpha-2 Protein, His Tag
catalog :
GF2-H5225
quantity :
200 ug, 1 mg
price :
280 USD, 1200 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
GF2-H5225
product name :
Human GFR alpha-2 Protein, His Tag
quantity :
200 ug, 1 mg
price :
280 USD, 1200 USD
quantity & price :
$280/200ug,$1200/1mg
target :
GFR alpha-2
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human GFR alpha-2, His Tag (GF2-H5225) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Ser 441 (Accession # NP_001486.4).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>97% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human GFR alpha-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%.
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at:
● -20°C to -70°C for 12 months in lyophilized state;
● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
GDNF family receptor alpha-2 (GFRA2) is also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.
References :
(1) Sanicola M., et al., 1997, Proc Natl Acad Sci U S A 94 (12): 6238–6243.
(2) Hisasue S.,et al., 2006, Neurobiol Aging. 27 (10): 1524-1530.
(3) Souza RP., et al., 2010, Psychopharmacology. 210 (3): 347-354.
company information
ACROBiosystems
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.
questions and comments