This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human GFR alpha-1 Protein, Fc Tag
catalog :
GF1-H5252
quantity :
1 mg
price :
1600 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
GF1-H5252
product name :
Human GFR alpha-1 Protein, Fc Tag
quantity :
1 mg
price :
1600 USD
quantity & price :
$1600/1mg
target :
GFR alpha-1
host species :
Human
By Tag :
Fc Tag
Research :
For Research Use Only
Source :
Human GFR alpha-1, Fc Tag (GF1-H5252) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Ser 424 (Accession # NP_665736.1).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>95% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human GFR alpha-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Formulation :
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at:
● -20°C to -70°C for 12 months in lyophilized state;
● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.
References :
(1) Angrist M, et al., 1998, Genomics 48 (3): 354–62.
(2) Jing, S., et al., 1997, J. Biol. Chem. (UNITED STATES) 272 (52): 33111–7.
(3) Cik, M., et al., 2000, J. Biol. Chem. (UNITED STATES) 275 (36): 27505–12.
(4) Klein, R D., et al., 1997, Nature (ENGLAND) 387 (6634): 717–21.
company information
ACROBiosystems
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.
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