This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human EphA2 Protein, His Tag
catalog :
EP2-H52H3
quantity :
1 mg, 100 ug
price :
2800 USD, 380 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
EP2-H52H3
product name :
Human EphA2 Protein, His Tag
quantity :
1 mg, 100 ug
price :
2800 USD, 380 USD
quantity & price :
$380/100ug,$2800/1mg
target :
EphA2
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human EphA2, His Tag (EP2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 204 - Thr 326 (Accession # P29317-1).
SDS-PAGE Remark(R&NR) :
Human EphA2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than .
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
References :
(1) Miao H, et al. 2009. Cancer Cell. 16(1):9-20. (2) Zhang G, et al. 2008. Cancer Res. 68(6):1691-6. (3) Miao H, et al. 2000. Nat Cell Biol. 2(2):62-9.
company information
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
info@acrobiosystems.com
http://www.acrobiosystems.com
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.