This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human CLIC4 Protein, His Tag
catalog :
CL4-H5141
quantity :
100 ug, 1 mg
price :
230 USD, 980 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
CL4-H5141
product name :
Human CLIC4 Protein, His Tag
quantity :
100 ug, 1 mg
price :
230 USD, 980 USD
quantity & price :
$230/100ug,$980/1mg (250ug × 4)
target :
CLIC4
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human CLIC4, His Tag (CL4-H5141) is expressed from E.coli cells. It contains AA Ala 2 - Lys 253 (Accession # AAH12444).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>92% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human CLIC4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: ● -20°C to -70°C for 12 months in lyophilized state; ● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Chloride intracellular channel protein 4 (CLIC4) ,a member of the chloride channel CLIC family, is also known as intracellular chloride ion channel protein p64H1,which contains one GST C-terminal domain. CLIC4 can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Also,CLIC4 can promote cell-surface expression of HRH3, endothelial cell proliferation and regulate endothelial morphogenesis. Furthermore ,CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.
References :
(1) Berryman M., et al., 2000, Mol. Biol. Cell 11:1509-1521. (2) Shanks R.A., et al., 2002, J. Biol. Chem. 277:40973-40980 (3) Suh K.S., et al., 2007, Clin. Cancer Res. 13:121-131.
company information
ACROBiosystems
1 Innovation Way Newark, DE 19711, USA
info@acrobiosystems.com
http://www.acrobiosystems.com
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.