This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human Activin RIB / ACVR1B Protein, Fc Tag
catalog :
ACB-H5251
quantity :
200 ug, 1 mg
price :
250 USD, 980 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
ACB-H5251
product name :
Human Activin RIB / ACVR1B Protein, Fc Tag
quantity :
200 ug, 1 mg
price :
250 USD, 980 USD
quantity & price :
$250/200ug,$980/1mg
target :
Activin RIB
host species :
Human
By Tag :
Fc Tag
Research :
For Research Use Only
Source :
Human ACVR1B, Fc Tag (ACB-H5251) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Glu 126 (Accession # AAH00254).
Endotoxin :
Less than 1.0 EU per μg by the LAL method.
Purity :
>92% as determined by SDS-PAGE.
SDS-PAGE Remark(R&NR) :
Human ACVR1B, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.
Formulation :
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at:
● -20°C to -70°C for 12 months in lyophilized state;
● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.
References :
(1) Carcamo J., et al., 1994, Mol. Cell. Biol. 14:3810-3821.
(2) Suzuki K., et al., 2010, Biochem. Biophys. Res. Commun. 394:639-645.
(3) Harrison C.A., et al., 2003, J. Biol. Chem. 278:21129-21135.
company information
ACROBiosystems
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.
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