This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ACROBiosystems
product type :
protein
product name :
Human ACE2 / ACEH (18-615) Protein, His Tag
catalog :
AC2-H52H3
quantity :
1 mg, 50 ug
price :
2600 USD, 350 USD
product information
company name :
ACROBiosystems
product type :
Protein
catalog :
AC2-H52H3
product name :
Human ACE2 / ACEH (18-615) Protein, His Tag
quantity :
1 mg, 50 ug
price :
2600 USD, 350 USD
quantity & price :
$350/50ug,$2600/1mg
target :
ACE2
host species :
Human
By Tag :
His Tag
Research :
For Research Use Only
Source :
Human ACE2 (18-615), His Tag (AC2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Asp 615 (Accession # Q9BYF1-1).
SDS-PAGE Remark(R&NR) :
Human ACE2 (18-615), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than .
Formulation :
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation.
Reconstitution :
Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage :
For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at:
● -20°C to -70°C for 12 months in lyophilized state;
● -70℃ for 3 months under sterile conditions after reconstitution.
Background :
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
References :
(1) Turner AJ., et al., 2002, Can. J. Physiol. Pharmacol. 80 (4): 346–53.
(2) Katovich MJ., et al., 2005, Exp. Physiol. 90 (3): 299–305.
(3) Donoghue M., et al., 2000, Circ. Res. 87:E1-E9.
(4) Tipnis S.R., et al., 2000, J. Biol. Chem. 275:33238-33243.
(5) Vickers C., et al., 2002, J. Biol. Chem. 277:14838-14843.
company information
ACROBiosystems
ACROBiosystems is a leading manufacturer of recombinant proteins and other critical reagents to support the development of target therapeutics. The company employs an application oriented development strategy, with a particular focus on product design, quality control and solution based support. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process. We have multiple offices and branches in North America, Europe, and Asia, and we are proud of serving customers from over 50 countries.
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