Labome reply
Thank you for contacting EMD Millipore Technical Services. This is a response to your ALDH2 AGONIST, ALDA-1 inquiry.
Please see the link to the product data sheet, http://www.emdmillipore.com/US/en/product/ALDH2-Agonist%2C-Alda-1---CAS-349438-38-6---Calbiochem,EMD_BIO-126920;pgid=WZtMKfaYs81SRpEoh9VgbI720000gWtsgaox?CategoryName=000000200002182700020023&CategoryDomainName=Merck-MerckMillipore#anchor_PDS
Per the reference, Chen, C.H., et al. 2008. Science 321, 1493, this compound selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKC? activator- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
Our products can be used for basic science research only. This research grade product manufactured in our company, cannot be used for any clinical trials in humans or veterinary animals. We are not FDA or GMP approved to manufacture this product for clinical trials.126920 | ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem can be used for only basic science research purpose in the labs.
From a literature search, I am not aware of any clinical trials for this product in humans.
I hope you find the following articles useful.
http://www.ncbi.nlm.nih.gov/pubmed/22404739
http://www.sciencebase.com/science-blog/alcoholic-drug-discovery-truths.html
http://www.jbc.org/content/285/2/943.full
http://cardiovascres.oxfordjournals.org/content/88/1/51
Please do not hesitate to contact me with any further questions.
Best Regards,
Ms. Lakshmi Iyer, Ph.D.
US
Senior Technical Specialist, Bioscience
EMD Millipore Corporation
Phone: (800) 221-1975 Extension 8010
Fax: (858) 453-3552