vascular endothelium
gene
reagent
sample publication
sample review
eNOS
nitric oxide synthase 3
total:36
Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. 2009 to the paper
Upstate Laboratories anti-eNOS antibody was used for western blot in order to investigate the role of purinergic in the regulation of endothelial nitric oxide synthase activity in endothelial cells. more
von Willebrand factor
total:32
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. 2009 to the paper
Serotec sheep anti-VWF was used to test von Willebrand factor (VWF) in order to research Rab27a and MyRIP's regulation to the amount and multimeric state of VWF released from endothelial cells. more
VE cadherin
cadherin 5
total:19
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
eBioscience anti-CD144 antibody was used in immunohistochemistry in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
VEGF
vascular endothelial growth factor A
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
tie-2
TEK receptor tyrosine kinase
total:11
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Flk-1 antibody was used in western blot in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
VEGFR-2
kinase insert domain receptor
total:35
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.. 2010 to the paper
Santa Cruz anti-Flk-1 antibody was used to perform immunoprecipitation in order to reveal the critical role of prorenin receptor and vacuolar H+-ATPase-mediated acidification in Wnt signaling. more
ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13
total:1
Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion. 2008 to the paper
Santa Cruz Biotechnology TTP antibody was used in immunocytochemistry in order to study the mechanism of persistent translation arrest
ICAM-1
intercellular adhesion molecule 1
total:30
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy. 2011 to the paper
R&D systems anti-ICAM-1 antibody was used to perform immunocytochemistry in order to study the remodelling of cortical actin at natural killer cell immune synapses. more
tissue factor
coagulation factor III, tissue factor
total:5
Versican G3 domain promotes blood coagulation through suppressing the activity of tissue factor pathway inhibitor-1. 2006 to the paper
BD Biosciences tissue factor antibody (CD142, clone number HTF-1) was used in western blot to detect its expression in culture medium and cell lysate from versican G3- or vector-transfected astrocytoma cell line U87 more
thrombomodulin
total:8
IL-32-dependent effects of IL-1beta on endothelial cell functions. 2009 to the paper
R&Dsystems anti-human CD141/TM antibody was used in western blot to study the role for IL-32 in the effect of IL-1 on endothelial cell functions. more
E-selectin
selectin E
total:5
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. 2008 to the paper
R&D monoclonal anti-E-selectin antibody (BBIG-E4) was used in immunohistochemistry to determine whether the heterogeneous clinical response to tumour necrosis factor (TNF) alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNFalpha expression in the synovium before initiation of treatment. more
PROCR
protein C receptor
total:4
Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. 2007 to the paper
R&D systems goat antihuman EPCR antibody was used in immunohistochemistry to determine the major cell type (s) that EPCR is associated with and whether EPCR functions to mediate the effects of activated protein C (APC) on these cells. more
VCAM-1
vascular cell adhesion molecule 1
total:19
The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways. 2009 to the paper
Immunotech anti-VCAM-1 antibody was used in blocking or activating expriments to study the role for prostate specific membrane antigen in regulating the expression of IL-6 and CCL5 in prostate tumour cells. more
endothelin 1
total:9
Expression of endothelial nitric oxide synthase and endothelin-1 in skin tissue from amputated limbs of patients with complex regional pain syndrome. 2008 to the paper
R&D systems rat anti-human ET-1 antibody (3G10) was used in immunohistochemistry to examine the distribution of eNOS and ET-1 in relation to vascular density represented by the endothelial marker CD31-immunoreactivity in skin tissue from amputated limbs of patients with CRPS. more
JNK
mitogen-activated protein kinase 8
total:193
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-JNK1 monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
AGER
advanced glycosylation end-product specific receptor
CD18
integrin subunit beta 2
total:23
CBFbeta is critical for AML1-ETO and TEL-AML1 activity. 2009 to the paper
eBioscience allophycocyanin (APC), phycoerythrin (PE), or PerCPcy5.5 conjugated anti Mac-1 (clone M1/70) antibody was used in flow cytometry in order to determine whether CBFbeta is required for AML1-ETO and TEL-AML1 activity more
CYBB
cytochrome b-245 beta chain
total:7
IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase. 2009 to the paper
BD Transduction monoclonal anti-Nox2 antibody was used in immunohistochemistry in order to study the role of IL-6 in degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice. more
CXCL12
C-X-C motif chemokine ligand 12
total:8
PTCH1 +/- dermal fibroblasts isolated from healthy skin of Gorlin syndrome patients exhibit features of carcinoma associated fibroblasts. 2009 to the paper
Abcam rabbit polyclonal anti-SDF1 alpha (alias CXCL12) antibody was used in western blot in order to demonstrate that PTCH1+/- genotype of healthy NBCCS fibroblasts is associated with basal cell carcinoma (BCC). more
BMPR2
bone morphogenetic protein receptor type 2
total:7
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. 2009 to the paper
R&D systems anti-BMPRII antibody was used to carry out western blot analysis in order to investigate the role for Smurf2 in promoting breast cancer metastasis. more
perlecan
heparan sulfate proteoglycan 2
total:5
WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. 2006 to the paper
Chemicon monoclonal anti-perlecan antibody (MAB 1948) was used in frozen sections from mouse and in immunohistochemistry to study the identification of WARP as a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. more
integrin alpha v
integrin subunit alpha V
total:24
TGFBI expression is associated with a better response to chemotherapy in NSCLC. 2010 to the paper
Chemicon Interational anti-integrin alphavbeta3 monoclonal was used to perform flow cytometry in order to determine if this integrin influences TGFBI-mediated NSCLC cell susceptibility to chemotherapy. more
CYP2C9
cytochrome P450 family 2 subfamily C member 9
total:4
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 to the paper
BD Gentest anti-CYP2C9 antibody (1:1000) was used in western blot in order to study the role of cardiomyocyte CPR and CPR-dependent enzymes in doxorubicin (Dox) mediated acute cardiotoxicity more
angiopoietin 2
total:5
Expression of angiopoietin-2 is correlated with vascularization and tumor size in human colorectal adenocarcinoma. 2007 to the paper
Santa Cruz Biotechnology rabbit-derived polyclonal Ang-1 antibody was used in immunohistochemistry to study angiopoietin-2 expression in human colorectal adenocarcinoma more
CRP
C-reactive protein
total:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 to the paper
Abcam monoclonal anti-C-reactive protein (CRP) antibody was used in immunohistochemistry to study the role for activated gp130 in inflammatory hepatocellular tumours. more
LFA-1
integrin subunit alpha L
total:14
Altered gene expression in early atherosclerosis is blocked by low level apolipoprotein E. 2008 to the paper
eBioscience CD11a antibody was used in immunohistochemistry in order to study the linkage between changes of adhesion molecules/cofactors and atherosclerosis more
VASH1
vasohibin 1
total:1
Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation. 2008 to the paper
R&D systems vasohibin antibody was used in western blot to compare the alternative splicing product of vasohibin 1 to major isoform (VASH1A) for antiangiogenic effects on endothelial colony forming cells.
EphB4
EPH receptor B4
total:7
The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. 2006 to the paper
Santa Cruz Biotech EphB4 antibody was used in western blot and immunohistochemistry to study the association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. more
TJP2
tight junction protein 2
total:3
EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability. 2008 to the paper
Zymed Laboratories rabbit polyclonal anti-ZO-2 antibody was used in western blot and immunocytochemistry to study the role for EspF in pedestal maturation and the disruption of paracellular permeability. more
integrin beta3
integrin subunit beta 3
total:28
Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression. 2010 to the paper
Santa Cruz Biotechnology mouse monoclonal integrin beta3 antibody (1:1000) was used in western blot in order to study the role of activated state of p42/44 and p38 in MMP-13 expression. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
ACVRL1
activin A receptor like type 1
total:4
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
R&D Systems goat anti-Acvrl1(AF370) antibody was used to perform immunohistochemistry and western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
NOX4
NADPH oxidase 4
total:2
Mutational analysis reveals distinct features of the Nox4-p22 phox complex. 2008 to the paper
Santa Cruz Biotechnology rabbit anti-Nox4 (7843) polyclonal antibody was used to perform western blot and immunocytochemistry in order to study the interaction of the key regulatory p22phox subunit with Nox4. more
ACE
angiotensin I converting enzyme
total:8
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Santa Cruz anti-ACE was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
MIR126
microRNA 126
PAI-1
serpin family E member 1
total:16
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. 2010 to the paper
Novus Biologicals goat anti-human plasminogen antibody was used to perform ELISA in order to investigate the interaction between leptospiral endostatin-like protein A and human plasminogen. more
p38
mitogen-activated protein kinase 14
total:189
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 to the paper
Biosource International anti-p38 antibody was used to perform western blot in order to study the effect of NFAT5 on hyperosmolar stressed human limbal epithelial cells. more
apelin
total:1
Apelin mediates the induction of profibrogenic genes in human hepatic stellate cells. 2010 to the paper
Santa Cruz Biotechnology rabbit anti-AP antibody was used to perform immunofluorescence in order to study the involvement of apelin in fibrogenesis during human liver disease.
Vegfr-3
fms related receptor tyrosine kinase 4
total:15
Expression of VEGF-C and its receptor VEGFR-3 in the bone marrow of patients with acute myeloid leukaemia. 2008 to the paper
Santa Cruz anti-VEGFR-3 (sc-321) antibody was used to perform immunohistochemistry in order to study the expression of VEGF-C and VEGFR-3 in the acute myeloid leukaemia patients' bone marrow. more
CXCR2
C-X-C motif chemokine receptor 2
total:9
The role of the chemokines MCP-1, GRO-alpha, IL-8 and their receptors in the adhesion of monocytic cells to human atherosclerotic plaques. 2008 to the paper
R&D Systems CXCR2 IgG2a antbody was used to inhibit cell adhesion in order to study the role of the chemokines MCP-1, GRO-alpha, IL-8, and their receptors in the adhesion of monocytic cells to human atherosclerotic plaques more
CXCR4
C-X-C motif chemokine receptor 4
total:39
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-CXCR4 was used in 3ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
P-selectin
selectin P
total:8
Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept. 2008 to the paper
Santa Cruz Biotechnology anti-P-selectin antibody was used in immunohistochemistry at 1:500 in order to evaluate an in vivo role of TNF-alphaR1 on the pathogenesis of inflammatory diseases more
CLDN5
claudin 5
total:3
Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. 2006 to the paper
Zymed Laboratories mouse anti-claudin-5 antibody was used in western blot and immunohistochemistry to demonstrate that CCL2 induces brain endothelial hyperpermeability via Rho/PKCalpha signal pathway interactions. more
DLL4
delta like canonical Notch ligand 4
total:1
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. 2007 to the paper
I. B. Lobov (Regeneron Pharmaceuticals) Dll4 antibody was used in immunohistochemistry to study the role of Dll4 during vascular growth and differentiation.
PGF
placental growth factor
total:3
A reproducible and quantifiable model of choroidal neovascularization induced by VEGF A165 after subretinal adenoviral gene transfer in the rabbit. 2008 to the paper
Upstate mouse monoclonal anti-FGF/anti-FGF-2 antibody (clone bFM-2) was used in immunohistochemistry to determine the effects of the vascular endothelial growth factor (VEGF) A165 delivered using a high capacity adenoviral vector (HC Ad.VEGF-A) on vascular growth and pathological changes in the rabbit eye. more
Flt-1
fms related receptor tyrosine kinase 1
total:16
The association of vascular endothelial growth factor receptor-1 with the risk of cancer progression following radical prostatectomy. 2008 to the paper
R&D Systems goat anti-human VEGFR-1 polyclonal antibody (catalog number: AF321) was used to perform immunochemistry assays in order to demonstrate that VEGFR-1 expression is not related to the risk of cancer progression following radical prostatectomy. more
FGF-2
fibroblast growth factor 2
total:20
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. 2009 to the paper
Chemicon rabbit polyclonal anti-FGF2 antibody was used in western blot to study the role for endothelial-derived FGF2 in the progression of pulmonary hypertension in humans and rodents. more