telomere
gene
reagent
sample publication
sample review
TERT
telomerase reverse transcriptase
total:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Calbiochem anti-TERT antibody (1:350) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule more
TRF2
telomeric repeat binding factor 2
total:16
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. 2009 to the paper
Millipore anti-TRF2 antibody was used to perform immunohistochemistry in order to study the function of HP1 proteins in the alternative lengthening of telomeres-associated PML bodies by p53/p21. more
TERC
telomerase RNA component
TRF1
telomeric repeat binding factor 1
total:5
Functional dissection of human and mouse POT1 proteins. 2009 to the paper
Sigma rabbit anti-mouse TRF1 (644) antibody was used in immunofluorescence in order to investigate the function of single-stranded telomeric DNA associated protein-POT1 in human and mice. more
CTC1
CST telomere replication complex component 1
RTEL1
regulator of telomere elongation helicase 1
total:1
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-RTEL1 was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19.
PINX1
PIN2 (TERF1) interacting telomerase inhibitor 1
TEN1
TEN1 subunit of CST complex
ATRX
ATRX chromatin remodeler
total:3
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. 2010 to the paper
Santa Cruz Biotechnology anti-ATRX was used to perform western-blot and immunoprecipitation in order to demonstrate that DAXX functions as a histone chaperone involved in the replication-independent deposition of H3.3. more
TNKS2
tankyrase 2
total:1
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. 2009 to the paper
Abcam anti-Tankyrase antibody was used to carry out western blot analysis and immunoprecipitation assays in order to find the novel substrates for transcription factor hypoxia-inducible factor in the proteome scale.
FEN1
flap structure-specific endonuclease 1
total:2
Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score. 2006 to the paper
Novocastra monoclonal anti-FEN-1 antibody was used in immunohistochemistry to investigate the expression and potential clinical usefulness of structure-specific flap endonuclease 1 (FEN-1) in human primary prostate cancer. more
histone H3
H3.3 histone A
total:12
Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. 2010 to the paper
Santa Cruz Biotechnology anti-Crem antibody was used to perform western blot and immunoprecipitation in order to study the role of Jmjd1a-controlled epigenetic histone modifications in Crem-regulated gene expression and spermatogenesis. more
SIRT6
sirtuin 6
total:3
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Abcam anti-SIRT6 was used to perform western blot in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
nucleostemin
G protein nucleolar 3
total:1
Human galectin-2: nuclear presence in vitro and its modulation by quiescence/stress factors. 2008 to the paper
Neuromics polyclonal anti-nucleostemin antibody was used to perform immunocytochemistry in order to study the in vitro nuclear presence and modulation of human galectin-2.
UPF1
UPF1 RNA helicase and ATPase
total:2
Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X. 2009 to the paper
San Diego polyclonal anti-human Upf-1 (hUpf-1) antibody was used in western blot in order to study that GABAA receptor alpha1 subunit mutation, 975delC, S326fs328X induce the activation of NMD and ERAD which contribute to epileptogenesis. more
ATM
ATM serine/threonine kinase
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
BLM
BLM RecQ like helicase
total:10
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination. 2008 to the paper
Novus anti-BLM antibody (NB100-161) was used to perform immunoprecipitation and western blot in order to study the formation of BLM-53BP1-RAD51 complex. more
uncoupling protein 2
total:3
Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 2005 to the paper
Santa Cruz Biotechnology Ucp2 antibody was used in western blot to study the molecular mechanisms in enhancing the resistance to infectious microorganisms by disrupting the uncoupling protein-2 gene. more
Ku70
X-ray repair cross complementing 6
total:19
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Abcam anti-Ku70 antibody was used to perform immunoblotting in order to studythe role of DNA-dependent protein kinase in the IRF-3-dependent innate immunity. more
DNA-PKcs
protein kinase, DNA-activated, catalytic subunit
total:12
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Millipore anti-DNA-PKcs antibody was used to perform western blot and immunofluorescence in order to study IRF-3-dependent innate immunity more
Ku80
X-ray repair cross complementing 5
total:22
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Life Technologies anti-Ku80 antibody was used to perform immunoprecipitation and immunofluorescence in order to study IRF-3-dependent innate immunity. more
lamin A/C
total:57
RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins. 2013 to the paper
Santa Cruz lamin A/C goat polyclonal (1:1000)was used to perform the immunoblotting to study the translation of a subset of mRNAs encoding secretory proteins potentiated by RanBP2/Nup358. more
BRCA2
BRCA2 DNA repair associated
total:10
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 to the paper
EMD anti-BRCA2 antibody was used to carry out immunofluorescence assays in order to investigate the role for FAN1 in promoting DNA interstrand cross-link repair by mono-ubiquitylating FANCI-FANCD2 complex. more
Daxx
death domain associated protein
total:14
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. 2010 to the paper
Santa Cruz Biotechnology anti-DAXX was used to perform western-blot and immunoprecipitation in order to demonstrate that DAXX functions as a histone chaperone involved in the replication-independent deposition of H3.3. more
PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
total:2
Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. 2005 to the paper
Santa Cruz Biotechnology anti-Pin-1 antibody was used in immunoprecipitation to study the interaction of tis21 protein with Pin-1 after phosphorylation of its Ser147 residue by p-Erk1/2. more
p53
tumor protein p53
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
p21
cyclin dependent kinase inhibitor 1A
total:178
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. 2012 to the paper
Abcam mouse anti-p21 antibody was used to perform western blot in order to study the mechanism through which doxorubicin suppressed tumor growth. more
BRCA1
BRCA1 DNA repair associated
total:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Calbiochem anti-BRCA1 monoclonal antibody was used to perform immunoprecipitation in order to study the function of apicobasal polarity and regulation of stem cell in breast cancer more
ApoE
apolipoprotein E
total:19
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 to the paper
Calbiochem anti-ApoE antibody was used in western blot to study the formation requirement of efficient hepatitis C virus particle. more
PML
promyelocytic leukemia
total:43
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. 2010 to the paper
Santa Cruz Biotechnology anti-PMLwas used to perform immunocytochemistry in order to demonstrate that DAXX functions as a histone chaperone involved in the replication-independent deposition of H3.3. more
SIRT1
sirtuin 1
total:13
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Abcam anti-SIRT1 was used to perform western blot in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
UBC
ubiquitin C
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more