subcellular fractions
gene
reagent
sample publication
sample review
total:13
Rac1 is a critical mediator of endothelium-derived neurotrophic activity. 2009 to the paper
Stressgen crystallin alphaB antibody was used in immunofluorescence to investigate the role of endothelial Rac1 in the regulation of endothelial barrier integrity and neurotrophic activity. more
total:2
Human retinal pigment epithelium cell changes and expression of alphaB-crystallin: a biomarker for retinal pigment epithelium cell change in age-related macular degeneration. 2007 to the paper
Stressgen 1:2500 alpha A-crystallin antibody was used in western blot to examine changes in the retinal pigment epithelium (RPE) in eyes with age-related macular degeneration (AMD) and specifically to characterize alphaB-crystallin expression in RPE cells as a biomarker in this disease. more
total:8
Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. 2008 to the paper
Santa Cruz anti-Vcalpain-1 antibody was used to perform western blot in order to show that ethanol can induce the expression and accumulation of tau in neuroblastoma cells. more
total:1
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. 2007 to the paper
Oncogene Research Products SphK1 antibody was used in western blot to study the role of lipid phosphate phosphatase (LPP) 1 and sphingosine kinase1 (SphK1) in converting exogenous S1P to intracellular S1P.
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:1
Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. 2005 to the paper
Santa Cruz Biotechnology MC1R antibody (N-19) antibody was used in western blot and immunohistochemistry to study its expression in skin cancer abd red hair persons
total:6
A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome. 2008 to the paper
BD Biosciences mouse monoclonal Rab27A antibody was used in western blot in order to study the role of Switch I region in the recruitment of Rab effector proteins. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:4
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-DJ-1 antibody was used to perform western blot in order to show that Nrf2 can be stabilized by DJ-1. more
total:11
Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. 2010 to the paper
Zymed anti-NPM antibody was used for western blot in order to investigate the role for activated Bax in the regulation of p53-dependent, transcription-independent neural precursor cell apoptosis. more
total:20
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. 2008 to the paper
Upstate monoclonal anti-PP2Ac antibody was used in western blot in order to study the abnormal hyperphosphorylation of tau and its possible causes in adult DS brains more
total:6
A yeast model of FUS/TLS-dependent cytotoxicity. 2011 to the paper
Abcam anti-FUS antibody (1:1000) was used to perform western blot in order to study the FUS/TLS-dependent cytotoxicity in yeast. more
total:81
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Chemicon anti-APP was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
total:26
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-TRAF2 (C-20) monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
total:12
Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. 2008 to the paper
Chemicon rabbit anti-APP C-terminal antibody and mouse anti-APP (6E10) antibody were used to perform western blot in order to study the effect of TNF-alpha on gamma-secretase. more
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:212
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. 2012 to the paper
Abcam Caspase-3 antibody was used to perform immunohistochemistry in order to study theeffect of thiabendazole on proliferation and apoptosis of human cells. more
total:7
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. 2012 to the paper
Abcam anti-SUMO2/3 was used to perform western blot in order to show that Myc-dependent cancer needs SUMOylation for tumorigenesis. more
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
total:10
Proteomic analysis of purified coronavirus infectious bronchitis virus particles. 2010 to the paper
Abcam rabbit polyclonal annexin A2 antibody (ab40943) was used to perform western blot in order to investigate proteomic profile of infectious bronchitis virus. more
total:79
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. 2012 to the paper
Santa Cruz Biotechnology anti-GSK3 beta antibody was used to perform western blot in order to investigate the role of GSK3-TIP60-ULK1 signaling pathway in autophagy. more
total:24
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Santa Cruz human ATR antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
total:60
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature. 2009 to the paper
Epitomics anti-calveolin-1 antibody was used for immunohistochemistry in order to show that a novel translocation involving chromosome 19 causes Xp11.2 translocation renal cell carcinoma. more
total:33
Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells. 2008 to the paper
Santa Cruz Biotechnology anti-alpha-syn mAb211 antibody was used to perform western blot in order to develop a cell modle of LB-associated neurodegeneration. more
total:9
Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. 2010 to the paper
Santa-Cruz Biotechnology anti-CK2 alpha antibody was used to carry out western blot analysis in order to investigate the role for NF-kB transcription factor in the interleukin-1 induced expression of C/EBP delta and APP genes. more
total:15
Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer. 2008 to the paper
Acris anti-MMP14(113-5B7) antibody was used to perform immunohistochemistry in order to study the expression of cytokeratin 7 and 19 are related with genomic stability and favorable prognosis in clear cell renal cell cancer. more
total:24
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. 2009 to the paper
GeneTex mouse monoclonal anti-ER antibody (C14C8) was used in immunohistochemistry, immunocytochemistry, and immunoprecipitation to study the effect of estrogen receptormediated nuclear interaction between IRS-1 and Rad51 on homologous recombination directed DNA repair in medulloblastoma. more
total:40
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. 2012 to the paper
Abcam anti-SUMO1 was used to perform western blot in order to show that Myc-dependent cancer needs SUMOylation for tumorigenesis. more
total:20
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. 2009 to the paper
BD rat monoclonal antibodies against mouse Gr-l were used in flow immunocytometry to investigate the role of the migrant cDCs in the regulation of CD11c, MHC II, and CD86. more
total:37
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. 2010 to the paper
ABCAM anti-human TARDBP antibody(ab57105, 1.25 mg/ml) was used to perform western blot in order to introduce a new recombinase-mediated cassette exchange system that allows targeted insertion and conditional expression of any given genes. more
total:1
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. 2009 to the paper
Santa Cruz Biotechnology LRRK2 rabbit polyclonal antibody was used to stain endogenous LRRK2 protein in order to determine the localization of endogenous LRRK2
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
total:118
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. 2012 to the paper
BD Pharmingen anti-p27CDKN1B antibody was used to perform western blot in order to show that p53-dependent cell proliferation and survival could be regulated by atg7. more
total:130
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Santa Cruz anti-Bcl-2 antibody (C-2, sc-7382, 1:500) was used to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
total:120
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Calbiochem anti-SRC antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:50
A male with unilateral microphthalmia reveals a role for TMX3 in eye development. 2010 to the paper
Santa Cruz Biotechnology rabbit anti-PKCAalpha antibody was used in western blot in order to study the function of TMX3 in eye development. more
total:35
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Calbiochem c-Abl antibody (1:1,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
total:6
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 to the paper
Calbiochem rabbit polyclonal antibody against adiponectin was used in western blot and immunoprecipitation to investigate the role of DLK in the regulation of 3T3-L1 adipocyte differentiation. more
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:54
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Upstate Biotechnology anti-HDAC1 antibody was used to perform western blot in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs. more
total:49
Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo. 2010 to the paper
Santa Cruz anti-RhoA antibody was used to perform immunohistochemistry in order to study the effect of silencing of RhoA and RhoC expression on human colorectal carcinoma growth in vivo. more
total:52
Overcoming mutation-based resistance to antiandrogens with rational drug design. 2013 to the paper
Upstate anti-AR (PG-21) antibody was used to perform ChIP in order to study the rational drug design for castration-resistant prostate cancer without mutation-based resistance to antiandrogens. more
total:100
Plasma membrane contributes to the formation of pre-autophagosomal structures. 2010 to the paper
Abcam anti-AP1-A1 antibody was used to perform western blot in order to study the role of plasma membrane in the formation of preautophagosomal structures. more
total:102
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. 2011 to the paper
Santa Cruz anti-BAX was used to perform western blot in order to show that chemotherapy is efficient for patients with high mitochondrial priming more
total:69
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. 2008 to the paper
Zymed Laboratories anti-c-erbB-2 antibody was used in immunohistochemistry to investigate the relationship between amphiregulin expression and liver metastases of colorectal cancer. more
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
total:112
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Santa Cruz anti-ERa antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:178
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. 2012 to the paper
Abcam mouse anti-p21 antibody was used to perform western blot in order to study the mechanism through which doxorubicin suppressed tumor growth. more
total:17
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. 2009 to the paper
Upstate Biotechnology mouse anti-CFTR antibody (clone M3A7) was used to perform western blot in order to investigate the mechanism for the long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. more
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more