respiratory mucosa
gene
reagent
sample publication
sample review
MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
total:10
TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells. 2013 to the paper
Neomarkers anti-MUC5AC antibody was used to perform western blot and immunocytochemistry in order to investigate the regulatory effect of TRPM5 activation on MUC5AC secretion from human colon goblet cells. more
CFTR
CF transmembrane conductance regulator
total:17
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. 2009 to the paper
Upstate Biotechnology mouse anti-CFTR antibody (clone M3A7) was used to perform western blot in order to investigate the mechanism for the long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. more
IL-8
C-X-C motif chemokine ligand 8
total:46
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
R&D systems anti-IL8 antibody was used to perform immunocytochemistry in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
DUOX2
dual oxidase 2
total:1
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. 2009 to the paper
Abgent anti-Duox2 rabbit antibody was used to perform western blot in order to study the regulation of the localization of functional Duox-DuoxA heterodimers.
TLR3
toll like receptor 3
total:9
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 to the paper
Santa Cruz Biotechnology goat polyclonal anti-human TLR3 was used in immunohistochemistry to study the expression of toll-like receptors in verruca and molluscum contagiosum in cryostat sections from human skin. more
EGFR
epidermal growth factor receptor
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
NKX2-1
NK2 homeobox 1
total:6
Characterizing the cancer genome in lung adenocarcinoma. 2007 to the paper
Santa Cruz Biotechnology anti-NKX2-1 polyclonal antibody was used to perform western blot in order to study the chromosome copy-number alterations in primary lung adenocarcinomas. more
DDX58
DExD/H-box helicase 58
total:1
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. 2008 to the paper
ABGENT anti-RIG-I antibody was used to perform western blot in order to study the cellular signaling elicited by human metapneumovirus in airway epithelial cells.
DUOX1
dual oxidase 1
total:1
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. 2009 to the paper
Abgent anti-Duox1 rabbit antibody was used to perform western blot in order to study the regulation of the localization of functional Duox-DuoxA heterodimers.
IL-13
interleukin 13
total:10
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
BD Pharmingen anti-IL-13 antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem. more
MKP-1
dual specificity phosphatase 1
total:17
Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. 2010 to the paper
Santa Cruz Biotechnology anti-MKP-1 antibody was used to perform immunohistochemistry in order to study the mechanism by which Angiotensin-(1-7) inhibited CAF growth and reduced tumour fibrosis in orthotopic breast tumors. more
CHRNA7
cholinergic receptor nicotinic alpha 7 subunit
total:2
Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization. 2008 to the paper
Santa Cruz Biotechnology nAChR alpha7 antibody was used in western blot in order to study the role of nAChR in the pathogenesis of choroidal neovascularization (CNV) more
IRF-3
interferon regulatory factor 3
total:22
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Life Technologies anti-IRF-3antibody was used to perform western blot in order to study IRF-3-dependent innate immunity more
SCNN1G
sodium channel epithelial 1 subunit gamma
total:1
Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. 2006 to the paper
Affinity Bioreagents anti-gammaENaC polyclonal antibody was used in western blot to detect gammaENaC in human H441 cells
IRF-1
interferon regulatory factor 1
total:14
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 to the paper
Santa Cruz Biotechnology anti-IRF-1 antibody was used to perform western blot and immunohistochemical in order to study epstein-barr virus (EBV) infection of human B lymphocytes with interferon regulatory factor 4 (IRF-4). more
TLR5
toll like receptor 5
total:4
Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.. 2008 to the paper
Santa Cruz Biotechnology rabbit polyclonal TLR5 antibody (2 ug/ml) was used in western blot in order to study the role of toll-Like receptors in the pathogenesis of lyme neuroborreliosis more
ELANE
elastase, neutrophil expressed
total:11
Mycobacterial disease and impaired IFN-? immunity in humans with inherited ISG15 deficiency. 2012 to the paper
Abcam anti-elastase antibody was used to perform western blot and immunocytochemistry in order to show that ISG15 deletion in humans impairs IFN-gamma immunity and results in mycobacterial disease susceptibility. more
p120ctn
catenin delta 1
total:23
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. 2009 to the paper
Santa Cruz Biotechnology polyclonal anti-p120-catenin antibody was used to carry out western blot analysis in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation. more
ITGB4
integrin subunit beta 4
total:12
A role for PVRL4-driven cell-cell interactions in tumorigenesis. 2013 to the paper
BD Biosciences mouse anti-ITGB4 antibody was used to perform western blot in order to investigate the role of PVRL4 in tumor progression. more
CHI3L1
chitinase 3 like 1
total:2
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. 2008 to the paper
R&D Systems goat polyclonal anti-human chitinase 3-like 1 antibody was used in western blot and immunohistochemistry to study the role for YKL-40 in modulating the biological activity of basic fibroblast growth factor. more
ADAM17
ADAM metallopeptidase domain 17
total:13
TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. 2008 to the paper
Santa Cruz Biotechnology anti-TACE antibody was used to perform Western Blot in order to show that TACE has a inhibitory role in EGFR axis in colorectal cancer. more
AQP5
aquaporin 5
total:6
Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). 2008 to the paper
Calbiochem anti-AQP5 antibody was used in immunohistochemistry to study the role for human AQP5 in the progression of chronic myelogenous leukemia in paraffin sections from human bronchial carcinoma tissues and normal bone marrow. more
CXCL10
C-X-C motif chemokine ligand 10
total:12
Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. 2009 to the paper
R&D Systems anti-CXCL10 antibody was used for immunocytochemistry in order to show the placental transcriptome of VUE and identify VUE combines maternal allograft rejection and maternal antifetal graft-vs-host disease. more
TLR2
toll like receptor 2
total:22
Inflammatory role of Toll-like receptors in human and murine adipose tissue. 2010 to the paper
Hycult Biotechnologies monoclonal anti-TLR2 was used to perform ELISA in order to show that Toll-like receptors in human and murine adipose tissue participate omental adipose tissue-related inflammation. more
TLR4
toll like receptor 4
total:37
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. 2010 to the paper
R&D mouse monoclonal anti-TLR4 antibody was used to perform western blot in order to study the immune defence role of TLR4 and HD5 in primary endocervical epithelial cells. more
MYD88
MYD88 innate immune signal transduction adaptor
total:3
Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. 2008 to the paper
eBioscience rabbit MyD88 antibody was used to perform western blot in order to study TLR2 and TLR4 expression in monocytes from T1DM patients. more
p50
nuclear factor kappa B subunit 1
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
hBD-2
defensin beta 4A
total:11
Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. 2010 to the paper
Biologo polyclonal rabbit anti-human HBD-2 was used to perform immunohistochemistry in dilution 1:100 and ELISA in dilution 1:1000 in order to show that the levels of human neutrophil peptides 1-3 secretion is inhibited by tumor necrosis factor and norepinephrine in mixed synovial tissue cultures from osteoarthritis and rheumatoid arthritis patients. more
MMP-7
matrix metallopeptidase 7
total:9
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 2010 to the paper
Santa Cruz Biotechnology anti-MMP7 antibody was used in immunohistochemistry to investigate the function of UPK1A in esophageal squamous cell carcinoma. more
IL-17
interleukin 17A
total:19
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
eBioscience anti-IL-17A mAb was used to perform flow cytometry and cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
MUC1
mucin 1, cell surface associated
total:28
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. 2010 to the paper
Lab Vision anti-MUC1-C antibody was used to perform immunoprecipitation in order to study the interaction between MUC1-C and STAT1 pathway in poor prognosis human breast cancers. more
MCP-1
C-C motif chemokine ligand 2
total:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 to the paper
Santa Cruz anti-MCP-1 antibody was used to perform immunohistochemistry in order to study the effect of MCP1 and CD40 ligation on VEGF production. more
PAR-2
F2R like trypsin receptor 1
total:6
Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. 2007 to the paper
Santa Cruz Biotechnology PAR2 antibody was used in immunohistochemistry to determine the expression and functions of PARs in the gallbladder epithelium. more
IL-4
interleukin 4
total:19
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 to the paper
R&D Systems anti-IL-4 was used in 5ug/ml to perform cell stimulation in order to show that blood-brain barrier integrity and CNS immune quiescence were promoted by sonic hedgehog pathway. more
CCL20
C-C motif chemokine ligand 20
total:1
Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells. 2008 to the paper
R&D Systems CCL20 antibdoy (1:100) was used in immunohistochemistry in order to study roles of EBNA1 in the escape of EBV-infected HL cells from the virus-specific CTL response
LL-37
cathelicidin antimicrobial peptide
total:8
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
HyCult Technologies anti-cathelicidin (3D11, 1:200) monoclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder. more
ERK2
mitogen-activated protein kinase 1
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
APC
APC regulator of WNT signaling pathway
total:11
A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. 2009 to the paper
Calbiochem anti-APC was used to perform immunocytochemistry in order to show that MRP protein plays an important role in adherens junction formation and tumorigenesis more
c-Jun
Jun proto-oncogene, AP-1 transcription factor subunit
total:100
Plasma membrane contributes to the formation of pre-autophagosomal structures. 2010 to the paper
Abcam anti-AP1-A1 antibody was used to perform western blot in order to study the role of plasma membrane in the formation of preautophagosomal structures. more
IL-1beta
interleukin 1 beta
total:30
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-1-beta mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
syndecan
syndecan 1
total:26
Heparanase regulates levels of syndecan-1 in the nucleus. 2009 to the paper
Cell Sciences B-A38 (Syndecan-1) antibody was used in western blot in order to demonstrate that heparanase can promote expression of syndecan-1 in the nucleus. more
MMP-9
matrix metallopeptidase 9
total:45
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 to the paper
Epitomics anti-MMP-9 antibody was used in immunohistochemistry to study the mechanism of protein kinase D1 for inhibiting breast tumour cell invasion. more
HO-1
heme oxygenase 1
total:10
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 to the paper
Stressgen anti-HO-1 antibody (1:500) was used in western blot in order to study the role of cardiomyocyte CPR and CPR-dependent enzymes in doxorubicin (Dox) mediated acute cardiotoxicity more
TGF-beta1
transforming growth factor beta 1
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
IL-6
interleukin 6
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
TNF-alpha
tumor necrosis factor
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
PTGS2
prostaglandin-endoperoxide synthase 2
total:54
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Santa Cruz Biotechnology anti-COX-2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more