precancerous conditions
gene
reagent
sample publication
sample review
total:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-p19 antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:4
Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas. 2008 to the paper
Novocastra mouse anti-MUC-6 antibody was used in immunohistochemistry to investigate the pathobiological behaviors of gastric mixed-type (MT) carcinomas and gastric carcinogenesis. more
total:54
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Santa Cruz Biotechnology anti-COX-2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:129
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. 2010 to the paper
AbCam anti-Ki67 was used to perform immunohistochemistry in order to study the roles of RBBP9 as a tumor-associated serine hydrolase to pancreatic neoplasia more
total:11
Low-grade gastric adenomas/dysplasias: phenotypic expression, DNA ploidy pattern, and LOH at microsatellites linked to the APC gene. 2008 to the paper
Novocastra anti-Cdx2 monoclonal antibody(1:100) was used to perform immumohistochemistry in order to study phenotypic expression, DNA ploidy pattern, and LOH of the APC gene linked microsatellites. more
total:3
Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer. 2008 to the paper
Dako anti-AMACR(13H4) antibody was used to perform immunohistochemistry in order to study the expression of cytokeratin 7 and 19 are related with genomic stability and favorable prognosis in clear cell renal cell cancer. more
total:6
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. 2009 to the paper
Zymed mouse anti-transferrin receptor antibody was used to perform western blot in order to investigate the mechanism for the long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. more
total:235
Regulation of early adipose commitment by Zfp521. 2012 to the paper
Santa Cruz Biotechnology anti-MYC antibody was used to carry out western blot and immunoprecipitation assays in order to investigate the regulatory role of Zfp521 in determining the switch between the adipogenic and osteogenic lineages. more
total:4
Altered regulation of Prox1-gene-expression in liver tumors. 2008 to the paper
Reliatech rabbit polyclonal anti-Podoplanin (1:500) antibody was used in immunohistochemistry to study Prox1-gene-expression in liver tumors more
total:9
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. 2010 to the paper
Santa Cruz Biotechnology anti-AhR antibody was used to carry out western blot analysis in order to investigate the role and mechanism for aryl hydrocarbon receptor Antagonist StemRegenin 1 in promoting the expansion of human hematopoietic stem cells. more
total:12
Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. 2009 to the paper
Santa Cruz anti-COX-1 antibody was used to perform western blot and immunohistochemistry in order to show that the cyclooxygenase-2 can leads to the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma. more
total:130
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Santa Cruz anti-Bcl-2 antibody (C-2, sc-7382, 1:500) was used to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
total:17
Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp. 2010 to the paper
Upstate anti-cortactin antibody was used for performing immunohistochemistry in order to study the role and contribution of CIP4 in human cancer cell motility and invasion. more
total:8
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. 2006 to the paper
Santa cruz biotechnology anti-Muc2 antibody was used to perform mmunohistochemistry assays in order to investigate the molecular regulation mechanisms of Smad4 in the process of normal pancreas development and pancreatic ductal adenocarcinomas (PDAC) growth. more
total:20
Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA. 2010 to the paper
Abcam anti-Cdk6 antibody was used to carry out western blot analysis in order to investigate the role for Herpesvirus saimiri Noncoding RNA HSURs in the regulation of host cell microRNAs. more
total:10
TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells. 2013 to the paper
Neomarkers anti-MUC5AC antibody was used to perform western blot and immunocytochemistry in order to investigate the regulatory effect of TRPM5 activation on MUC5AC secretion from human colon goblet cells. more
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
total:26
Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. 2014 to the paper
Santa Cruz Biotechnology anti-p63 antibody was used to perform immunohistochemistry in order to study TNFa/TNFR2 axis protective role for skin against DUOX1-mediated oxidative stress. more
total:2
miR-183 inhibits TGF-beta1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells. 2010 to the paper
Proteintech Group anti-PDCD4 antibody (12587-1-AP) was used to perform western blot in order to clarify that miR-183 could inhibit TGF-beta1-induced apoptosis by repressing the PDCD4 expression in human HCC cells. more
total:1
RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. 2008 to the paper
Active Motif rabbit polyclonal anti-RUNX3 antibody was used in immunocytochemistry to study the interaction between E4orf6, E1B-55K, and RUNX1 and the association of the RUNX1 with centers of viral DNA and RNA synthesis.
total:8
Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. 2012 to the paper
Immune Systems goat anti-Sox2 antibody was used to perform immunocytochemistry in order to study the mechanism that underlied termination of body axis elongation in embryos. more
total:44
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. 2010 to the paper
Millipore anti-CDK4 antibody was used to perform western blot in order to study the roles of the fragile X mental retardation protein during the regulations of the proliferation and differentiation of adult neural stem/progenitor cells. more
total:69
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. 2008 to the paper
Zymed Laboratories anti-c-erbB-2 antibody was used in immunohistochemistry to investigate the relationship between amphiregulin expression and liver metastases of colorectal cancer. more
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
total:9
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 2010 to the paper
Santa Cruz Biotechnology anti-MMP7 antibody was used in immunohistochemistry to investigate the function of UPK1A in esophageal squamous cell carcinoma. more
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:6
Proteomic analysis of low dose arsenic and ionizing radiation exposure on keratinocytes. 2009 to the paper
Santa Cruz anti-S100A9 antibody was used to perform western blot in order to study the proteomic of the keratinocytes after the treatment of low dose arsenic and ionizing radiation exposure. more
total:12
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. 2006 to the paper
Santa Cruz Biotechnology anti-Fas-L antibody was used in western blot to study the role of HYAL1-v1 in regulating in bladder cancer growth, infiltration, and angiogenesis in transfected human HT1376 bladder cancer cells. more
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
total:2
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Epitomics anti-Aldh1 antibody (1:150) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
total:11
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation. 2006 to the paper
Santa Cruz Biotechology anti-p110 gamma antibody was used in western blot in order to investigate the mechanism of the PI3K-IA (phosphatidylinositol 3-kinase Class IA) lipid kinase activity was affected by high NaCl and ionizing radiation. more
total:123
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-Cyclin D1 antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:24
Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men. 2008 to the paper
Calbiochem anti-MLH1 antibody (1:75) was used to perform western blot and immunoprecipitation in order to study the function of small ubiquitin-related modifier (SUMO) 1, SUMO-2/3 and SUMOylation. more
total:178
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. 2012 to the paper
Abcam mouse anti-p21 antibody was used to perform western blot in order to study the mechanism through which doxorubicin suppressed tumor growth. more
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
total:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Calbiochem anti-TERT antibody (1:350) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule more
total:77
LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications. 2010 to the paper
Santa Cruzrabbit polyclonal anti-pRB antibody was used to perform immunohistochemistry in order to study the role of two interacting proteins LIMD1 and pRB in development of head and neck squamous cell carcinoma (HNSCC). more
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
total:8
Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin. 2008 to the paper
Santa Cruz affinity purified goat polyclonal Cyp1B1 antibody was used in western blot in order to study the role of estrogen metabolism in estrogen-induced breast carcinogenesis more
total:13
Extended flow cytometry characterization of normal bone marrow progenitor cells by simultaneous detection of aldehyde dehydrogenase and early hematopoietic antigens: implication for erythroid differentiation studies. 2008 to the paper
R&D Systems anti-105 antibody was used to perform flow cytometry in order to study the new characterization about the dissection of normal bone marrow progenitor cells more
total:8
Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. 2013 to the paper
R&D systems monoclonal anti-mouse SHH N-term peptide antibody and biotinylated anti-mouse SHH antibody were used to perform ELISA in order to investigate the role of CDON in regulating tumor cell survival. more
total:14
The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. 2013 to the paper
GeneTex anti-VHL antibody was used to perform western blot and immunoprecipitation in order to investigate the regulatory effect of HILDA complex on VEGF-A expression. more
total:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Calbiochem anti-BRCA1 monoclonal antibody was used to perform immunoprecipitation in order to study the function of apicobasal polarity and regulation of stem cell in breast cancer more
total:20
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Oncogene Ras antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:8
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-Braf antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:52
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology FAS antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:21
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Bethyl Laboratories anti-p73 was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
total:11
A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. 2009 to the paper
Calbiochem anti-APC was used to perform immunocytochemistry in order to show that MRP protein plays an important role in adherens junction formation and tumorigenesis more
total:17
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 to the paper
Epitomics anti-Notch1 antibody was used to carry out western blot analysis in order to investigate the regulation of Notch signaling and cell differentiation by mTOR signaling. more
total:28
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. 2010 to the paper
Lab Vision anti-MUC1-C antibody was used to perform immunoprecipitation in order to study the interaction between MUC1-C and STAT1 pathway in poor prognosis human breast cancers. more
total:10
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 to the paper
EMD anti-BRCA2 antibody was used to carry out immunofluorescence assays in order to investigate the role for FAN1 in promoting DNA interstrand cross-link repair by mono-ubiquitylating FANCI-FANCD2 complex. more
total:30
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-1-beta mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
total:38
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. 2010 to the paper
Calbiochem anti-Hdm2 antibody was used for western blot in order to investigate the role of TGFB1 in the regulation of Mdm2 expression and late-stage breast cancer metastasis. more
total:14
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
Santa Cruz Biotechnology anti-Nrf2 antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:49
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. 2013 to the paper
Millipore rat anti-heparan sulfate proteoglycan monoclonal antibody was used to perform immunohistochemistry in order to investigate the role of sFLT-1 in the maintenance of the avascular photoreceptor layer in mouse models. more
total:1
Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio. 2006 to the paper
R&D Systems IL-1RA ELISA ket was used to study inflammatory response induced by glucan
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:12
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Calbiochem anti-osteopontin antibody (1:100) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
total:2
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients. 2008 to the paper
Lab Vision Corporation anti-GSTM antibody was used to perform immunocytochemistry in order to show that the expression of glutathione S-transferase pi is at a higher level in the brains of medically intractable epileptic patients. more
total:13
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
Abcam rabbit anti-IGF-1 antibody was used in western blot to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
total:15
Potential therapeutic significance of increased expression of aryl hydrocarbon receptor in human gastric cancer. 2009 to the paper
Chemicon International anti-CYP 1A1 antibody (AB1258) was used in western blot to determine the functional significance of aryl hydrocarbon receptor (AhR) in gastric carcinogenesis, and to explore the possible role of AhR in gastric cancer (GC) treatment more
total:9
Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1. 2010 to the paper
Assay Designs anti-manganese superoxide dismutase antibody was used to perform western blot in order to study the interaction between F1L and endogenous Bak. more
total:37
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. 2010 to the paper
R&D mouse monoclonal anti-TLR4 antibody was used to perform western blot in order to study the immune defence role of TLR4 and HD5 in primary endocervical epithelial cells. more
total:112
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Santa Cruz anti-ERa antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more