parkinson disease
gene
reagent
sample publication
sample review
total:33
Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells. 2008 to the paper
Santa Cruz Biotechnology anti-alpha-syn mAb211 antibody was used to perform western blot in order to develop a cell modle of LB-associated neurodegeneration. more
total:1
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. 2009 to the paper
Santa Cruz Biotechnology LRRK2 rabbit polyclonal antibody was used to stain endogenous LRRK2 protein in order to determine the localization of endogenous LRRK2
total:4
Inhibition of mitochondrial fusion by ?-synuclein is rescued by PINK1, Parkin and DJ-1. 2010 to the paper
Novus Biologicals polyclonal anti-PINK1 antibody was used to perform immunoblotting in order to study the influence of PINK1, parkin and DJ-1 on alpha-synuclein-mediated inhibition of mitochondrial fusion. more
total:4
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-DJ-1 antibody was used to perform western blot in order to show that Nrf2 can be stabilized by DJ-1. more
total:1
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. 2007 to the paper
Dr. Juan S. Bonifacino (National Institute of Child Health and Human Development) Vps35 antibody was used in western blot and immunoprecipitation to study the functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors
total:1
The DnaJ-domain protein RME-8 functions in endosomal trafficking. 2005 to the paper
MBL International mouse monoclonal antibody against auxilin 2 (also known as cyclin-G-associated kinase) was used in western blot to study the function of a DnaJ domain-containing protein RME-8 in endosomal trafficking.
total:5
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. 2010 to the paper
Santa Cruz Biotechnology anti-EIF4G antibody was used to perform immunocytochemistry in order to study the interaction between TDP-43 and proteins that regulate RNA metabolism. more
total:7
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. 2008 to the paper
Chemicon UCH-L1 antibody was used in western blot at dilution of 1/2000 in order to identify 14-3-3 beta and zeta isoforms and proteolytic fragments of alpha-spectrin as proteins released from degenerating neurons more
total:1
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. 2005 to the paper
BD Biosciences mouse monoclonal antibody to DGK theta theta was used in western blot to provide evidence in vitro and in vivo for a major role for PKCepsilon and/or PKCeta activation in the regulation of DGKdelta translocation to the plasma membrane.
total:5
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. 2010 to the paper
Epitomics HTRA2 antibody was used to perform western blot in order to indicate an important role for the ubiquitin ligase activity of HOIP in CD40 signaling. more
total:1
Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. 2010 to the paper
Zymed anti-Abeta-synuclein antibody was used to perform immunohistochemistry in order to study neuropathological variation within the frontal and temporal lobes of 94 cases of FTLD-TDP.
total:45
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Proteintech Group MAPT antibody (1:1500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:4
Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. 2009 to the paper
BD Biosciences anti-UbcH7 antibody was used to perform immunohistochemistry in order to study the regulation of ubiquitin-conjugating enzyme H7 in S phase of the cell cycle. more
total:6
Dopamine neurons express multiple isoforms of the nuclear receptor nurr1 with diminished transcriptional activity. 2005 to the paper
Santa Cruz Biotechnology anti-nurr1 antibody was used in immunocytochemistry to demonstrate that multiple splice variants of nurr1 are produced in rat and human dopamine neurons. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:25
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. 2010 to the paper
Stressgen monoclonal anti-Hsc70 antibody was used to carry out western blot analysis in order to determine the atomic structure of human adenovirus. more
total:8
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. 2010 to the paper
Cell Signaling Technology anti-phospho-Ser235/236-S6 antibody was used to perform immunocytochemistry in order to study the capacity of rapamycin to provide neuroprotection in Parkinson disease models. more
total:7
Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. 2009 to the paper
Santa Cruz anti-dopamine transporter (DAT) antibody was used for western blot analysis to study therapeutic effects of RPE cell transplantation in Parkinson's disease. more
total:5
Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import. 2007 to the paper
Affinity BioReagents anti-Cdc37 antibody was used in western blot in order to investigate the functions of Hsp40-related J-domain proteins DJA1, DJA2, and DJA4 during mitochondrial import. more
total:29
Overcoming mutation-based resistance to antiandrogens with rational drug design. 2013 to the paper
Santa Cruz Biotechnology anti-beta-tubulin (D-10) antibody was used to perform western blot in order to study the rational drug design for castration-resistant prostate cancer without mutation-based resistance to antiandrogens. more
total:25
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Abcam anti-Tyrosine Hydroxylase antibody (ab6211) was used to perform immunohistochemistry in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
total:4
Mechanisms of Chlamydia trachomatis entry into nonphagocytic cells. 2007 to the paper
Chemicon anti-NSF antibody was used to carry out immunofluorescence assays in order to investigate the mechanism of entry for Chlamydia trachomatis into nonphagocytic cells. more
total:24
Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. 2012 to the paper
Abcam rabbit anti-LAMP2 was used to perform immunocytochemistry in order to show that ciliogenesis was regulated by an evolutionarily assembled cis-regulatory module more
total:3
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. 2009 to the paper
Stressgene anti-GRP75 antibody (SPA825) was used in western blot to study the role for kinesin 5B in cancer cells. more
total:7
D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin. 2007 to the paper
Chemicon rabbit polyclonal anti-D2L/S (catalog number AB5084P) antibody was used in western blot to study the regulation of D1 and D2 dopamine receptor expression by direct interaction with the chaperone protein calnexin more
total:2
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. 2009 to the paper
Zymed Laboratories monoclonal anti-D3R antibody was used to perform western blot in order to study the important role of GRK4 in D3 receptor's signaling in human proximal tubule cells. more
total:4
ER tubules mark sites of mitochondrial division. 2011 to the paper
Abcam anti-Dnm1L was used to perform western blot in order to show that mitochondrial fission could be mediated by ER tubules. more
total:35
In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis. 2009 to the paper
Stressgen mouse anti-Hsp70antibody was used to perform western blot in order to show that enhancing CHIP activity is good for therapy for SCA3 or other polyQ diseases more
total:68
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-HSP90 was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
total:1
Endurance exercise as a countermeasure for aging. 2008 to the paper
Affinity Bioreagents anti-TFAM antibody was used in western blot in order to investigate whether the mitochondrial dysfunction and reduced insulin sensitivity are inevitably caused by aging.
total:3
Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. 2008 to the paper
Sigma anti-Vcalpastatin antibody was used to perform western blot in order to show that ethanol can induce the expression and accumulation of tau in neuroblastoma cells. more
total:22
Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. 2008 to the paper
Beckman-Coulter anti-HLA DR- PC5 was used to perform flow cytometry in order to show that IRAK-1 blockade is important for tolerance of human DCs induced by TLR2 and TLR4 stimulation. more
total:19
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 to the paper
Calbiochem anti-ApoE antibody was used in western blot to study the formation requirement of efficient hepatitis C virus particle. more
total:10
Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons. 2009 to the paper
Chemicon rabbit anti-NR2B antibody was used in western blot and immunoprecipitation to investigate the role of dorsal horn GluR2 internalization in the regulation of NMDA receptor/PKC-dependent nociceptive hypersensitivity. more
total:37
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. 2010 to the paper
ABCAM anti-human TARDBP antibody(ab57105, 1.25 mg/ml) was used to perform western blot in order to introduce a new recombinase-mediated cassette exchange system that allows targeted insertion and conditional expression of any given genes. more
total:79
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. 2012 to the paper
Santa Cruz Biotechnology anti-GSK3 beta antibody was used to perform western blot in order to investigate the role of GSK3-TIP60-ULK1 signaling pathway in autophagy. more
total:11
Differential expression of neurotrophins in postnatal C57BL/6 mice striatum. 2009 to the paper
Chemicon International antibodies against BDNF was used in immunohistochemistry in order to confirm the differential expression of neurotrophins in postnatal C57BL/6 mice striatum. more
total:14
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
Santa Cruz Biotechnology anti-Nrf2 antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:36
Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. 2010 to the paper
Santa Cruz Biotechnology anti-Cdc42 antibody was used in western blot to reveal the effect of slit2 on eosinophil and neutrophil during lung inflammation. more
total:81
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Chemicon anti-APP was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
total:1
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. 2007 to the paper
Chemicon 1H9 antibody against ataxin-3 and 1C2 antibody directed against expanded polyglutamines were used in western blot and immunohistochemistry to study nuclear localization of ataxin-3 and its role in the manifestation of symptoms in SCA3
total:38
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. 2011 to the paper
Cell Signaling Technology anti-4E-BP1 and phospho-T37/T46 4E-BP1, phospho-S65 4E-BP1 were used to perform western blot in order to show that how growth factor signaling is inhibited by mTOR through mTOR-regulated phosphoproteome. more