neurodegenerative diseases
gene
reagent
sample publication
sample review
total:33
Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells. 2008 to the paper
Santa Cruz Biotechnology anti-alpha-syn mAb211 antibody was used to perform western blot in order to develop a cell modle of LB-associated neurodegeneration. more
total:45
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Proteintech Group MAPT antibody (1:1500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:37
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. 2010 to the paper
ABCAM anti-human TARDBP antibody(ab57105, 1.25 mg/ml) was used to perform western blot in order to introduce a new recombinase-mediated cassette exchange system that allows targeted insertion and conditional expression of any given genes. more
total:9
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. 2010 to the paper
Santa Cruz rabbit anti-HDAC6 antibody (WB, 1:2000; IF, 1:500) was used to perform western blot and immunofluorescence in order to study knockdown of TDP-43 mediated HDAC6 downregulation. more
total:1
Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. 2011 to the paper
Abcam antibody mouse rabbit anti-CHMP2B antibody was used to perform immunohistochemistry in order to study quantification of CHMP2B on intercellular bridges at different stages.
total:8
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. 2009 to the paper
Santa Cruz Biotechnology anti-Cdk5 (SC-173), Cdk5-pTyr-15 (SC-12918), and Cdk5-pSer-159 (SC-12919) antibodies were used to perform western blot in order to investigate the molecular mechanisms underlying CRMP2 function in CXCL12-induced T lymphocyte migration. more
total:81
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Chemicon anti-APP was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
total:7
Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy. 2010 to the paper
R&D Systems anti-human monoclonal/ biotinylated PGRN antibody was used to perform ELISA in order to study the progranulin's neuroprotective effect in vivo and therapeutic potential for motor axonopathy. more
total:14
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
Santa Cruz anti-p62 antibody was used to perform immunocytochemistry in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
total:5
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. 2010 to the paper
Epitomics HTRA2 antibody was used to perform western blot in order to indicate an important role for the ubiquitin ligase activity of HOIP in CD40 signaling. more
total:17
No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected. 2011 to the paper
Chemicon anti-Prion Protein was used to perform PCR in order to show that CFS patients do not have murine-like gammaretroviruses in their blood. more
total:40
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. 2012 to the paper
Abcam anti-SUMO1 was used to perform western blot in order to show that Myc-dependent cancer needs SUMOylation for tumorigenesis. more
total:7
RhoE Is required for keratinocyte differentiation and stratification. 2009 to the paper
Abcam rabbit polyclonal anti-transglutaminase antibody was used in western blot to study the role for RhoE in keratinocyte differentiation and stratification more
total:21
Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues. 2008 to the paper
Santa Cruz polyclonal anti-Hsp60 was used to perform immunocytochemistry in dilution 1:500 in order to show that acetylshikonin and analogues induce apoptosis through orphan nuclear receptor Nur77-mediated apoptotic pathway in cancer cells. more
total:6
A yeast model of FUS/TLS-dependent cytotoxicity. 2011 to the paper
Abcam anti-FUS antibody (1:1000) was used to perform western blot in order to study the FUS/TLS-dependent cytotoxicity in yeast. more
total:13
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Abcam anti-SIRT1 was used to perform western blot in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:14
The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97. 2008 to the paper
Progen Biotechnik GmbH anti-VCP/p97 monoclonal antibody was used to perform Western Blot in order to study the possible role of VCP/p97 in myelomonocytic differentiation and retrodifferentiation. more
total:79
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. 2012 to the paper
Santa Cruz Biotechnology anti-GSK3 beta antibody was used to perform western blot in order to investigate the role of GSK3-TIP60-ULK1 signaling pathway in autophagy. more
total:16
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. 2009 to the paper
Stressgen anti-SOD1 antibody was used in western blot in order to demonstrate that locomotor defect associated with aggregation can be found in an ALS-linked mutant SOD1. more
total:12
Huntingtin facilitates polycomb repressive complex 2. 2010 to the paper
Chemicon-Milliporeanti-huntingtin antibody was used for immunoblotting in order to illustrate the full-length huntingtin's helical organization and role as a facilitator of the multi-subunit PRC2 complex. more
total:14
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
Santa Cruz Biotechnology anti-Nrf2 antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:19
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 to the paper
Calbiochem anti-ApoE antibody was used in western blot to study the formation requirement of efficient hepatitis C virus particle. more
total:1
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. 2009 to the paper
Santa Cruz Biotechnology LRRK2 rabbit polyclonal antibody was used to stain endogenous LRRK2 protein in order to determine the localization of endogenous LRRK2
total:11
Differential expression of neurotrophins in postnatal C57BL/6 mice striatum. 2009 to the paper
Chemicon International antibodies against BDNF was used in immunohistochemistry in order to confirm the differential expression of neurotrophins in postnatal C57BL/6 mice striatum. more