nerve degeneration
gene
reagent
sample publication
sample review
tau
microtubule associated protein tau
total:45
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Proteintech Group MAPT antibody (1:1500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
alpha synuclein
synuclein alpha
total:33
Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells. 2008 to the paper
Santa Cruz Biotechnology anti-alpha-syn mAb211 antibody was used to perform western blot in order to develop a cell modle of LB-associated neurodegeneration. more
APP
amyloid beta precursor protein
total:81
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Chemicon anti-APP was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
TDP 43
TAR DNA binding protein
total:37
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. 2010 to the paper
ABCAM anti-human TARDBP antibody(ab57105, 1.25 mg/ml) was used to perform western blot in order to introduce a new recombinase-mediated cassette exchange system that allows targeted insertion and conditional expression of any given genes. more
Cu Zn superoxide dismutase
superoxide dismutase 1
total:16
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. 2009 to the paper
Stressgen anti-SOD1 antibody was used in western blot in order to demonstrate that locomotor defect associated with aggregation can be found in an ALS-linked mutant SOD1. more
LRRK2
leucine rich repeat kinase 2
total:1
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. 2009 to the paper
Santa Cruz Biotechnology LRRK2 rabbit polyclonal antibody was used to stain endogenous LRRK2 protein in order to determine the localization of endogenous LRRK2
FTL
ferritin light chain
total:3
Control of iron homeostasis by an iron-regulated ubiquitin ligase. 2009 to the paper
Sigma anti-ferritin antibody was used to perform western blot in order to study the roles of the iron-regulated ubiquitin ligase in the regulation towards the iron homeostasis. more
huntingtin
total:12
Huntingtin facilitates polycomb repressive complex 2. 2010 to the paper
Chemicon-Milliporeanti-huntingtin antibody was used for immunoblotting in order to illustrate the full-length huntingtin's helical organization and role as a facilitator of the multi-subunit PRC2 complex. more
PS1
presenilin 1
total:12
Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. 2008 to the paper
Chemicon rabbit anti-APP C-terminal antibody and mouse anti-APP (6E10) antibody were used to perform western blot in order to study the effect of TNF-alpha on gamma-secretase. more
FUS
FUS RNA binding protein
total:6
A yeast model of FUS/TLS-dependent cytotoxicity. 2011 to the paper
Abcam anti-FUS antibody (1:1000) was used to perform western blot in order to study the FUS/TLS-dependent cytotoxicity in yeast. more
UCHL1
ubiquitin C-terminal hydrolase L1
total:7
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. 2008 to the paper
Chemicon UCH-L1 antibody was used in western blot at dilution of 1/2000 in order to identify 14-3-3 beta and zeta isoforms and proteolytic fragments of alpha-spectrin as proteins released from degenerating neurons more
Bax
BCL2 associated X, apoptosis regulator
total:102
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. 2011 to the paper
Santa Cruz anti-BAX was used to perform western blot in order to show that chemotherapy is efficient for patients with high mitochondrial priming more
GSK3beta
glycogen synthase kinase 3 beta
total:79
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. 2012 to the paper
Santa Cruz Biotechnology anti-GSK3 beta antibody was used to perform western blot in order to investigate the role of GSK3-TIP60-ULK1 signaling pathway in autophagy. more
prion protein
total:17
No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected. 2011 to the paper
Chemicon anti-Prion Protein was used to perform PCR in order to show that CFS patients do not have murine-like gammaretroviruses in their blood. more
ApoE
apolipoprotein E
total:19
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 to the paper
Calbiochem anti-ApoE antibody was used in western blot to study the formation requirement of efficient hepatitis C virus particle. more
HIF-1 alpha
hypoxia inducible factor 1 subunit alpha
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more