neoplasms
gene
reagent
sample publication
sample review
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:4
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 2011 to the paper
Abcam goat anti-PKM1/2 was used in 1:2000 to perform western blot in order to show that antioxidant responses could be achieved by pyruvate kinase M2 inactivation. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:33
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Santa Cruz polyclonal anti-mTOR (N-19 (alpha-FRAP) was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
total:38
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. 2010 to the paper
Calbiochem anti-Hdm2 antibody was used for western blot in order to investigate the role of TGFB1 in the regulation of Mdm2 expression and late-stage breast cancer metastasis. more
total:1
Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 2010 to the paper
Novus goat anti-PGAM1 antibody was used to carry out western blot analysis in order to clarify an alternative glycolytic pathway in many rapidly proliferating cells.
total:5
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. 2010 to the paper
BD Pharmingen monoclonal anti-NKG2D-allophycocyanin antibody was used to perform flow cytometry in order to show multiple CD3 Zeta-dependent receptor functions can be impaired simultaneously by pathological NKG2D ligand expression. more
total:2
Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. 2008 to the paper
Abgent anti-human NEK6 was used to perform western blot in dilution 1:500 in order to show that differentially overexpressed genes in gastric cancer are revealed by combining large-scale gene expression profiling and network analysis. more
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
total:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Calbiochem anti-TERT antibody (1:350) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule more
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
total:2
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-DPYD was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
total:1
The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells. 2006 to the paper
Affinity Biologicals SNF2L antibody was used in western blot, immunoprecipitation, immunocytochemistry, and ChIP assay to study the regulation of steroidogenic acute regulatory protein expression by imitation switch protein SNF2L during terminal differentiation of ovarian granulosa cells
total:2
Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. 2009 to the paper
Santa Cruz anti-Ubc3 antibody was used to perform immunohistochemistry in order to study the regulation of ubiquitin-conjugating enzyme H7 in S phase of the cell cycle. more
total:4
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. 2007 to the paper
Santa Cruz anti-CAIX antibody was used to perform western blot in order to study the dependency on oxidative phosphorylation during transformation of human mesenchymal stem cells. more
total:235
Regulation of early adipose commitment by Zfp521. 2012 to the paper
Santa Cruz Biotechnology anti-MYC antibody was used to carry out western blot and immunoprecipitation assays in order to investigate the regulatory role of Zfp521 in determining the switch between the adipogenic and osteogenic lineages. more
total:9
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. 2007 to the paper
Topogen mouse anti-TOP1 monoclonal antibody(1:50) was used to perform immunofluoresence in order to study the mechanism of genetic disease ataxia telangiectasia (AT) in the nucleus of human Purkinje neurons. more
total:23
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Rockland anti-pT232 Aurora B was used to perform immunocytochemistry in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
total:1
The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. 2007 to the paper
Dr. D. Keppler (German Cancer Research Center) human OATP1B3 antibody was used in western blot to investigate the potential role of macrolides on macrolide-induced drug interactions.
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
total:8
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. 2009 to the paper
Zymed mouse monoclonal anti-Skp1 antibody was used in western blot to investigate the regulation of Cdc20 stability during SAC activation in mammalian cells and explore the contribution of spindle checkpoint proteins to Cdc20 stability. more
total:35
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.. 2010 to the paper
Santa Cruz anti-Flk-1 antibody was used to perform immunoprecipitation in order to reveal the critical role of prorenin receptor and vacuolar H+-ATPase-mediated acidification in Wnt signaling. more
total:68
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-HSP90 was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
total:175
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Abcam anti-PARP1 was used to perform western blot in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:6
Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. 2005 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-TRAIL antibody was used in western blot to investigate the role of human BVR in sodium arsenite (As) mediated induction of HO-1 and in cytoprotection against apoptosis by small interference RNA-mediated gene silencing. more
total:5
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-MDMX antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
total:14
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
Santa Cruz Biotechnology anti-Nrf2 antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:14
The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1. 2009 to the paper
Santa Cruz Biotechnology anti-YY1 antibody was used in western blot to study the effect of expression of the SYT-SSX2 oncogene on polycomb function in human U2OS osteosarcoma cell line. more
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:120
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Calbiochem anti-SRC antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:59
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. 2010 to the paper
Santa Cruz anti-Chk1 monoclonal antibody was used to perform western blot in order to study the interactions of ATR and ATRIP in gene expression and production of virus during HSV-1 infection. more
total:7
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Abcam anti-ABCG2 antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
total:11
Pharmacological brake-release of mRNA translation enhances cognitive memory. 2013 to the paper
Santa Cruz Biotechnologies anti-CREB-2 antibody was used to perform western blot in order to investigate the molecular mechanism of memory consolidation. more
total:5
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. 2008 to the paper
Lab Vision rabbit-anti-RBX1 antibody was used in western blot in order to identify the poxviral motif as a functional F-box more
total:4
Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. 2009 to the paper
Santa Cruz Biotechnology Keap1 antibody was used in immunohistochemistry in order to suggest that the defective machinery for ISP synthesis affect the oxidative stress response in friedreich ataxia. more
total:3
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. 2009 to the paper
BD Biosciences Itch monoclonal antibody was used to perform western blot and immunoprecipitation in order to demonstrate the key mechanisms that regulate p63 protein stability in vivo. more
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
total:1
WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. 2010 to the paper
Abnova polyclonal alpha-WRAP53 full-length antibody (H00055135-B01) was used to perform western blot in order to identify WRAP53 as an essential factor for Cajal body maintenance and for directing the SMN complex to Cajal bodies.
total:1
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. 2007 to the paper
Abgent anti-Dnmt3L antibody was used in ChIP assay to define a mechanism for Stat4-dependent genetic programming of a Th1-associated gene.
total:77
LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications. 2010 to the paper
Santa Cruzrabbit polyclonal anti-pRB antibody was used to perform immunohistochemistry in order to study the role of two interacting proteins LIMD1 and pRB in development of head and neck squamous cell carcinoma (HNSCC). more
total:62
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore Gamma-H2AX antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
total:10
Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. 2009 to the paper
Santa Cruz Biotechnology anti-Cdc25A antibody was used in western blot in order to study the role of TRAIL for activation of DNA damage response pathways with histone H2AX and Chk2 phosphorylations. more
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:21
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Bethyl Laboratories anti-p73 was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
total:34
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Santa Cruz Biotechnology anti-Mcl-1 antibody was used to perform western blot in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
total:28
Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance. 2009 to the paper
R&D systems anti-XIAP antibody was used in western blot to investigate the role of PARP-1 in the NF-kB signalling cascade induced by ionizing radiation more
total:37
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Santa Cruz E2F1 antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:4
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
Santa Cruz Biotechnology anti-Cul3 antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:24
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Santa Cruz human ATR antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
total:5
Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies. 2009 to the paper
Santa Cruz mouse monoclonal Sam68 antibody was used for western blot in order to prove that CPEB1 is accumulated in Crm1 nucleolar bodies. more
total:1
Histone ubiquitination associates with BRCA1-dependent DNA damage response. 2009 to the paper
Bethyl anti-RNF20 antibody was used in immunoprecipitation in order to confirm that histone ubiquitination cause DNA damage.
total:1
Cell-cell contact globally activates microRNA biogenesis. 2009 to the paper
Upstate anti-Ago antibody was used to perform western blot in order to study the association between the cell-cell contact and microRNA biogenesis.
total:73
Detachment of esophageal carcinoma cells from extracellular matrix causes relocalization of death receptor 5 and apoptosis. 2009 to the paper
R&D systems anti-casp8 antibody was used to carry out western blot analysis in order to investigate the mechanism of DR5 relocalization and its effect on cell apoptosis during adhesion to detachment of EC9706 cells. more
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
total:11
Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. 2010 to the paper
Zymed anti-NPM antibody was used for western blot in order to investigate the role for activated Bax in the regulation of p53-dependent, transcription-independent neural precursor cell apoptosis. more
total:37
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. 2013 to the paper
BD BioSciences anti-eIF4E antibody was used to perform western blot in order to check the protein levels when hnRNP-Q was knocked down. more
total:6
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. 2006 to the paper
Stressgen monoclonal anti-HSF1 antibody was used in human HeLa cells and in western blot, EMSA to study the role for the effects of MK2 on the regulation of HSF1 in inhibiting transcriptional activity and promotes HSP90 binding. more
total:15
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. 2010 to the paper
eBioscience rabbit polyclonal anti-DR5 antibody was used in flow cytometry in order to investigate the roles of Fas ligand and TRAIL in the regulation of murine thymic graft-versus-host disease. more
total:4
Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells. 2006 to the paper
S Chada (Introgen Therapeutics) MDA-7 antibody was used in western blot to demonstrate that combination of Ad-mda7 with Herceptin may be a novel therapy for breast cancer. more
total:31
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Calbiochem anti-Bim antibody was used to perform immunoprecipitation in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
total:30
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues. 2009 to the paper
R&D rabbit anti-pMET antibody was used to perform immunohistochemistry in order to study the function of the fixative in the immunohistochemical detection of phosphoproteins. more
total:46
MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. 2010 to the paper
Santa Cruz Biotechnology anti-RAF1 antibody was used to perform western blot in order to study the role of microRNA-7 in tongue squamous cell carcinoma cells. more
total:2
67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. 2005 to the paper
Abcam polyclonal 67LR antibody (Ab711) was used in western blot and immunoprecipitation to study the role of 67-kDa Laminin Receptor Escherichia coli K1 internalization in human brain microvascular endothelial cells more