negative regulation of TCF-dependent signaling by WNT ligand antagonists
gene
reagent
sample publication
sample review
DKK1
dickkopf WNT signaling pathway inhibitor 1
total:5
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. 2008 to the paper
Abcam goat anti-human Dkk-1 anti-body was used to perform immunohistochemistry in order to investigate the expression alteration of dickkopfs (Dkks) and kremen2 (Krm2) in gastrointestinal cancer. more
DKK2
dickkopf WNT signaling pathway inhibitor 2
total:2
EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. 2009 to the paper
Biovision anti-DKK2 antibody was used to detect secreted DKK2 in western blot in order to demonstrate that the expression of the dickkopf family in Ewing family tumor cells were affected by EWS/ETS. more
KREMEN2
kringle containing transmembrane protein 2
total:1
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. 2008 to the paper
ABGENT rabbit anti-human Dkk-4 antibody was used to perform immunohistochemistry in order to investigate the expression alteration of dickkopfs (Dkks) and kremen2 (Krm2) in gastrointestinal cancer.
LRP5
LDL receptor related protein 5
total:2
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. 2009 to the paper
Cell Signaling anti-LRP5 antibody was used in western blot in order to show that Wnt/catenin signaling, osteoblast function, and bone formation can be negatively regulated by the N-cadherin-axin-LRP5 interaction. more
LRP6
LDL receptor related protein 6
total:6
Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. 2010 to the paper
Santa Cruz anti-LRP6 antibody was used to perform western blot in order to study a mechanism for an angiogenic inhibitor in the serine proteinase family inhibitor by blocking Wnt pathway more
SFRP1
secreted frizzled related protein 1
total:2
Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma. 2007 to the paper
Rockland rabbit anti-SFRP1 polyclonal antibody (600-401-475) antibody was used in western blot (1:100) and in immunohistochemistry (1:300) to study the role of SFRP1 down-regulation in human hepatocellular carcinoma more
WNT3A
Wnt family member 3A
total:1
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. 2008 to the paper
Zymed Laboratories/Invitrogen Wnt3a antibody was used in immunohistochemistry in order to quantify and localize the expression and activity of the Wnt/beta-catenin pathway in IPF
WNT4
Wnt family member 4
total:2
Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. 2008 to the paper
Santa Cruz Biotechnology affinity-purified polyclonal Wnt-4 antibody was used in western blot in order to demonstrate that integration beta-catenin/Lef-1/Tcf-3 signaling with ERalpha is necessary for estrogen-dependent endogenous gene regulation in uterine biology more
WNT5A
Wnt family member 5A
total:4
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. 2010 to the paper
R&D Wnt5A antibody was used to perform western blot in order to investigate the effection of Wnt5A to ROR2 more