mTOR signalling
gene
reagent
sample publication
sample review
total:38
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. 2011 to the paper
Cell Signaling Technology anti-4E-BP1 and phospho-T37/T46 4E-BP1, phospho-S65 4E-BP1 were used to perform western blot in order to show that how growth factor signaling is inhibited by mTOR through mTOR-regulated phosphoproteome. more
total:14
The ancient drug salicylate directly activates AMP-activated protein kinase. 2012 to the paper
Cell Signalling anti-pAMPK was used to perform western blot in order to show that AMPK could be activated by salicylate directly. more
total:1
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. 2009 to the paper
Epitomics MO25 rabbit monoclonal antibody was used for Western blotting in order to investigate the effect of LKB1 on nucleocytoplasmic transport.
total:4
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. 2010 to the paper
Cell Signaling Technology anti-phospho-eIF4B antibody was used to carry out western blot analysis in order to investigate the precise contribution of 4E-BPs to mTORC1 signaling. more
total:37
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. 2013 to the paper
BD BioSciences anti-eIF4E antibody was used to perform western blot in order to check the protein levels when hnRNP-Q was knocked down. more
total:5
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. 2010 to the paper
Santa Cruz Biotechnology anti-EIF4G antibody was used to perform immunocytochemistry in order to study the interaction between TDP-43 and proteins that regulate RNA metabolism. more
total:7
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. 2008 to the paper
Santa Cruz Biotechnology anti-Lkb1 antibody was used to perform western blot and immunohistochemistry in order to study the acinar polarity defects and cystic neoplasms induced by Lkb1-deficient in pancreas. more
total:33
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Santa Cruz polyclonal anti-mTOR (N-19 (alpha-FRAP) was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
total:60
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. 2011 to the paper
Cell Signaling anti-S6K1 and phospho-T389 S6K1 was used to perform western blot in order to show that vacuolar H+-ATPase is involved in mTOR pathway for mTORC1 translocation and activation. more
total:15
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Cell Signaling Technologies anti-PRKAA1 antibody was used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
total:4
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
R&D technologies anti-PRKAA2 antibody was used to carry out western blot analysis and ChIP assays in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
total:1
The ancient drug salicylate directly activates AMP-activated protein kinase. 2012 to the paper
Abcam anti-AMPK-gamma1 was used to perform western blot in order to show that AMPK could be activated by salicylate directly.
total:8
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. 2011 to the paper
Cell Signaling anti-raptor was used to perform western blot in order to show that vacuolar H+-ATPase is involved in mTOR pathway for mTORC1 translocation and activation. more
total:2
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. 2005 to the paper
Santa Cruz Biotechnology anti-Rheb antibody (C-19) was used in western blot to study amino acids mediate mTOR activation by signaling through class 3 PI3K, hVps34. more
total:36
p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum. 2012 to the paper
Cell Signalling anti-S6 (rabbit monoclonal) antibody was used to perform immunoblotting in order to study the effect of p180 on the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum. more
total:9
Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. 2010 to the paper
Zymed Laboratories anti-TSC1 antibody was used to perform western blot and immunoprecipitation in order to study how carboxy terminal tail of polycystin-1 inhibit mTOR via increasing the interaction between TSC2 and TSC1. more
total:26
Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. 2010 to the paper
Epitomics anti-TSC2 antibody was used to perform western blot and immunoprecipitation in order to study the mechanism by which carboxy terminal tail of polycystin-1 repress mTOR signaling via membrane retention of TSC2. more