lymphocytes
gene
reagent
sample publication
sample review
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit
total:3
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-XPD was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
OGG1
8-oxoguanine DNA glycosylase
total:9
RAS transformation requires CUX1-dependent repair of oxidative DNA damage. 2014 to the paper
Pierce anti-OGG1 antibody was used to perform Western Blotting in order to study CUX1-dependent repair of RAS-induced senescence. more
GSTM1
glutathione S-transferase mu 1
total:2
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients. 2008 to the paper
Lab Vision Corporation anti-GSTM antibody was used to perform immunocytochemistry in order to show that the expression of glutathione S-transferase pi is at a higher level in the brains of medically intractable epileptic patients. more
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
Fas
Fas cell surface death receptor
total:52
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology FAS antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
H2AX
H2A.X variant histone
total:62
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore Gamma-H2AX antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
LDLR
low density lipoprotein receptor
total:10
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. 2009 to the paper
Santa Cruz anti-LDLr antibody was used in western blot in order to show that Wnt/catenin signaling, osteoblast function, and bone formation can be negatively regulated by the N-cadherin-axin-LRP5 interaction. more
GRK2
G protein-coupled receptor kinase 2
total:9
Uncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2. 2008 to the paper
Santa Cruz Biotechnolog GRK2 polyclonal antibody was used to immunodetect myocardial levels in order to study the uncoupling of myocardial beta-Adrenergic receptor signaling during coronary artery bypass grafting: The Role of GRK2 more
mu opioid receptor
opioid receptor mu 1
total:2
Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. 2005 to the paper
Incstar rabbit anti-OPRM1 antibody was used in western blot to detect OPRM1 in CHO cells transfected with wild type and variant OPRM1. more
BRCA2
BRCA2 DNA repair associated
total:10
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 to the paper
EMD anti-BRCA2 antibody was used to carry out immunofluorescence assays in order to investigate the role for FAN1 in promoting DNA interstrand cross-link repair by mono-ubiquitylating FANCI-FANCD2 complex. more
FasL
Fas ligand
total:12
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. 2006 to the paper
Santa Cruz Biotechnology anti-Fas-L antibody was used in western blot to study the role of HYAL1-v1 in regulating in bladder cancer growth, infiltration, and angiogenesis in transfected human HT1376 bladder cancer cells. more
pericentrin
total:8
Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. 2011 to the paper
Abcam anti-pericentrin antibody was used to perform immunocytochemistry in order to study the secretion of natural killer cell lytic granule at the immune synapse. more
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
total:1
MiR-33 contributes to the regulation of cholesterol homeostasis. 2010 to the paper
Santa Cruz Biotechnology polyclonal anti-HMGCR antibody was used to carry out western blot analysis in order to investigate the role for intronic miRNA miR-33 in the regulation of cholesterol metabolism.
p53
tumor protein p53
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
HLA B
major histocompatibility complex, class I, B
total:1
Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 to the paper
PharMingen anti-HLA-B antibody was used in flow cytometry immunophenotyping to study the function of fibromodulin which serves as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL) to enable the expansion of specific CD8+ autologous T lymphocytes
IRF5
interferon regulatory factor 5
total:1
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Abcam goat anti-IRF5 polyclonal antibody was used to perform immunoprecipitation in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs.
GSTP1
glutathione S-transferase pi 1
total:9
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. 2009 to the paper
Sigma mouse GG-7 Fc-specific anti-human IgG antibody was used to confirm the presence of the Fc fragment of human IgG in order to illustrate that Toll-like receptor 4 (TLR4) plays a fundamental role in the sensing of LPS from Gram-negative bacteria. more
CD38
CD38 molecule
total:21
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-CD38 was used in 1ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
XPC
XPC complex subunit, DNA damage recognition and repair factor
total:2
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 to the paper
Abcam anti-XPC antibody was used to perform western blot in order to study the DNA damage and response by UV. more
frataxin
total:1
Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. 2009 to the paper
Santa Cruz Biotechnology frataxin antibody was used in immunohistochemistry in order to suggest that the defective machinery for ISP synthesis affect the oxidative stress response in friedreich ataxia.
BRCA1
BRCA1 DNA repair associated
total:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Calbiochem anti-BRCA1 monoclonal antibody was used to perform immunoprecipitation in order to study the function of apicobasal polarity and regulation of stem cell in breast cancer more
CD28
CD28 molecule
total:25
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. 2012 to the paper
eBioscience anti-human CD28 was used to perform blocking or activating experiments in order to show that cancer cell depended on glycine for rapid proliferation. more
IL-13
interleukin 13
total:10
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
BD Pharmingen anti-IL-13 antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem. more
HLA-A
major histocompatibility complex, class I, A
total:8
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. 2008 to the paper
Santa Cruz Biotechnology anti-HLA-A(A-18) antibody was used to perform immunohistochemistry in order to study tumor and tumor-stromal cell interactions. more
CD4
CD4 molecule
total:118
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. 2011 to the paper
Beckman coulter anti-CD4 PC5 was used to perform flow cytometry in order to show that human long-term engrafting HSCs could be isolated with CD49f as a marker. more
Bcl 2
BCL2 apoptosis regulator
total:130
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Santa Cruz anti-Bcl-2 antibody (C-2, sc-7382, 1:500) was used to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
Bim
BCL2 like 11
total:31
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Calbiochem anti-Bim antibody was used to perform immunoprecipitation in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
CD25
interleukin 2 receptor subunit alpha
total:49
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. 2009 to the paper
eBioscience anti-CD25 antibody was used in flow cytometry in order to investigate the role of dendritic cells in the regulation of spontaneous fatal autoimmunity. more
S1PR1
sphingosine-1-phosphate receptor 1
total:3
Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. 2005 to the paper
Santa Cruz Biotechnology goat polyclonal Edg-1 antibody was used in western blot to study the mechanism of Rac activation induced by S1P more
IL33
interleukin 33
total:1
IL-33 exacerbates antigen-induced arthritis by activating mast cells. 2008 to the paper
Axxora anti-IL-33 antibody was used in immunohistochemistry to study the role of the effect of IL-33 on mast cells in antigen-induced arthritis in paraffin sections from human synovial tissue.
Nbs1
nibrin
total:28
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Novus NBS1 antibody was used to perform immunofluorescence assay in order to study the requirement of RSFI in DSB repair. more
TNF-alpha
tumor necrosis factor
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
BDNF
brain derived neurotrophic factor
total:11
Differential expression of neurotrophins in postnatal C57BL/6 mice striatum. 2009 to the paper
Chemicon International antibodies against BDNF was used in immunohistochemistry in order to confirm the differential expression of neurotrophins in postnatal C57BL/6 mice striatum. more
IL-17
interleukin 17A
total:19
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
eBioscience anti-IL-17A mAb was used to perform flow cytometry and cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
interleukin 2
total:17
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
BD Pharmingen anti-IL-2 antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem. more
T bet
T-box transcription factor 21
total:1
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
Becton Dickinson anti-TBET antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem.
ATM
ATM serine/threonine kinase
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
NRG1
neuregulin 1
total:3
Immortalization and characterization of lineage-restricted neuronal progenitor cells derived from the porcine olfactory bulb. 2008 to the paper
Abcam rabbit anti-neuregulin-1 antibody (1:100) was used in immunocytochemistry in order to study the role of CCR5 in the migration of pulmonary fibrocytes and the promotion of metastasis more
Lck
LCK proto-oncogene, Src family tyrosine kinase
total:18
CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. 2007 to the paper
Upstate Biotechnology Lck antibody was used in western blot to study the role of flotillin-1 in chemokine receptor signaling and receptor partitioning with lipid rafts. more
HLA-C
major histocompatibility complex, class I, C
total:7
Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. 2009 to the paper
Invitrogen Purified goat IgG was used as the isotypic controls in order to identify the MHC I molecule (HLA-C) as an attachment factor in facilitating HCoV-HKU1 spike (S) mediated infection. more
IFN-gamma
interferon gamma
total:62
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 to the paper
R&D Systems anti-IFN-gamma was used in 5ug/ml to perform cell stimulation in order to show that blood-brain barrier integrity and CNS immune quiescence were promoted by sonic hedgehog pathway. more
PKR
eukaryotic translation initiation factor 2 alpha kinase 2
total:30
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.. 2009 to the paper
Epitomics rabbit monoclonal phospho-PKR antibody was used to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2. more
p27
cyclin dependent kinase inhibitor 1B
total:118
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. 2012 to the paper
BD Pharmingen anti-p27CDKN1B antibody was used to perform western blot in order to show that p53-dependent cell proliferation and survival could be regulated by atg7. more