lung neoplasms
gene
reagent
sample publication
sample review
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:20
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Oncogene Ras antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:7
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL. 2009 to the paper
Zymed Laboratories mouse anti-ALK (1:4000, 4C5B8) antibody was used to study the role of ALK in the pathogenesis and the treatment of anaplastic large cell lymphoma. more
total:6
Characterizing the cancer genome in lung adenocarcinoma. 2007 to the paper
Santa Cruz Biotechnology anti-NKX2-1 polyclonal antibody was used to perform western blot in order to study the chromosome copy-number alterations in primary lung adenocarcinomas. more
total:2
Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization. 2008 to the paper
Santa Cruz Biotechnology nAChR alpha5 antibody was used in western blot in order to study the role of nAChR in the pathogenesis of choroidal neovascularization (CNV) more
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:30
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues. 2009 to the paper
R&D rabbit anti-pMET antibody was used to perform immunohistochemistry in order to study the function of the fixative in the immunohistochemical detection of phosphoproteins. more
total:3
Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. 2008 to the paper
Imran M. Khan (University of California, San Diego) rabbit polyclonal nAChR alpha3 subunit antibody was used in immunohistochemistry to further characterize intrathecal (IT) delivery of nicotinic agonists. more
total:2
An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. 2007 to the paper
Chemicon International mouse monoclonal anti-RRM1 (1:500) antibody was used in western blot to study the association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients more
total:7
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. 2008 to the paper
Santa Cruz Biotechnology anti-Lkb1 antibody was used to perform western blot and immunohistochemistry in order to study the acinar polarity defects and cystic neoplasms induced by Lkb1-deficient in pancreas. more
total:3
Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells. 2008 to the paper
BD Pharmingen anti-ASCL1 monoclonal antibody was used to perform western blot in order to study the effects of valproic acid in medullary thyroid cancer cells. more
total:4
Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. 2009 to the paper
Santa Cruz Biotechnology Keap1 antibody was used in immunohistochemistry in order to suggest that the defective machinery for ISP synthesis affect the oxidative stress response in friedreich ataxia. more
total:3
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-XPD was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
total:15
Potential therapeutic significance of increased expression of aryl hydrocarbon receptor in human gastric cancer. 2009 to the paper
Chemicon International anti-CYP 1A1 antibody (AB1258) was used in western blot to determine the functional significance of aryl hydrocarbon receptor (AhR) in gastric carcinogenesis, and to explore the possible role of AhR in gastric cancer (GC) treatment more
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
total:14
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
Santa Cruz Biotechnology anti-Nrf2 antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
total:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Calbiochem anti-TERT antibody (1:350) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule more
total:3
Tumorigenic and metastatic activity of human thyroid cancer stem cells. 2010 to the paper
Novocastra anti-TTF1 antibody was used to perform immunohistochemistry in order to find out what activities of human thyroid cancer stem cells could be potential targets to treat thyroid carcinoma. more
total:1
CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody. 2006 to the paper
BD Gentest anti-human CYP2A6 monoclonal antibody was used in western blotting and immunohistochemistry to study the role of CYP2A13 in human respiratory tissues and lung cancers.
total:23
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. 2009 to the paper
Santa Cruz Biotechnology polyclonal anti-p120-catenin antibody was used to carry out western blot analysis in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation. more
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
total:5
Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. 2010 to the paper
BD anti-pan-MCM antibody was used in western blot in order to investigate the mechanism of how the embryonic stem cells chromatin structure change was regulated by condensin complexes during mitotic progression. more
total:69
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. 2008 to the paper
Zymed Laboratories anti-c-erbB-2 antibody was used in immunohistochemistry to investigate the relationship between amphiregulin expression and liver metastases of colorectal cancer. more
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
total:7
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. 2008 to the paper
Novus Biologicals mouse monoclonal APE1 antibody was used to carry out chromatin immunoprecipitation assays in order to investigate the transcriptional regulatory function of APE1 and its association with drug resistance in tumor cells. more
total:9
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. 2009 to the paper
Sigma mouse GG-7 Fc-specific anti-human IgG antibody was used to confirm the presence of the Fc fragment of human IgG in order to illustrate that Toll-like receptor 4 (TLR4) plays a fundamental role in the sensing of LPS from Gram-negative bacteria. more
total:4
Mutational inactivation of STAG2 causes aneuploidy in human cancer. 2011 to the paper
Santa Cruz anti-RASSF1A was used to perform western blot in order to show that aneuploidy in tumor cells is associated with STAG2 inactivation. more
total:12
Tumorigenic and metastatic activity of human thyroid cancer stem cells. 2010 to the paper
Dako anti-cytokeratin 19 antibody was used to perform immunohistochemistry in order to find out what activities of human thyroid cancer stem cells could be potential targets to treat thyroid carcinoma. more
total:37
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion. 2009 to the paper
Santa Cruz monoclonal MMP-2 antibodies were used in western blot in order to investigate the role of matrix metalloproteinase-2 (MMP-2) gene in invasiveness and adhesion of human pancreatic cancer cell line, BxPC-3. more
total:3
Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population. 2010 to the paper
Affinity-Biomol International mouse monoclonal anti-human 20S proteasome subunit alpha4 was used for immunohistochemistry to investigate the effect of immunoproteasome on the Multiple Sclerosis pathogenesis. more
total:2
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients. 2008 to the paper
Lab Vision Corporation anti-GSTM antibody was used to perform immunocytochemistry in order to show that the expression of glutathione S-transferase pi is at a higher level in the brains of medically intractable epileptic patients. more
total:45
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 to the paper
Epitomics anti-MMP-9 antibody was used in immunohistochemistry to study the mechanism of protein kinase D1 for inhibiting breast tumour cell invasion. more
total:9
RAS transformation requires CUX1-dependent repair of oxidative DNA damage. 2014 to the paper
Pierce anti-OGG1 antibody was used to perform Western Blotting in order to study CUX1-dependent repair of RAS-induced senescence. more
total:34
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Santa Cruz Biotechnology anti-Mcl-1 antibody was used to perform western blot in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
total:11
The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. 2008 to the paper
Zymed Laboratory anti-NSE (G4) antibody was used to perform immunohistochemistry in order to study the diagnostic value of SYT-SSX detected by RT-PCR and FISH for synovial sarcoma. more
total:26
Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. 2014 to the paper
Santa Cruz Biotechnology anti-p63 antibody was used to perform immunohistochemistry in order to study TNFa/TNFR2 axis protective role for skin against DUOX1-mediated oxidative stress. more
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
total:4
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. 2008 to the paper
BioGenex Laboratories rabbit anti-human bombesin antibody was used in immunohistochemistry in order to develop a combined histochemical and immunohistochemical procedure to reveal the dual nature of goblet cell carcinoide more
total:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
Santa Cruz Biotechnology anti-STAT3 monoclonal antibody was used to perform western blot to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
total:21
Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. 2012 to the paper
Santa Cruz anti-OCT4 antibody was used to perform Chip in order to show that in human embryonic stem cells there are non-canonical TAF complexes regulate active promoters. more
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:60
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature. 2009 to the paper
Epitomics anti-calveolin-1 antibody was used for immunohistochemistry in order to show that a novel translocation involving chromosome 19 causes Xp11.2 translocation renal cell carcinoma. more
total:33
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Santa Cruz polyclonal anti-mTOR (N-19 (alpha-FRAP) was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
total:40
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
Santa Cruz Biotechnology PE-conjugated anti-IGF-1R antibody was used in flow cytometry to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
total:6
Nitric oxide destabilizes Pias3 and regulates sumoylation. 2007 to the paper
Santa Cruz polyclonal anti-Pias3 was used to perform western blot and immunoprecipitation in order to show that global sumoylation and Pias3 stabilization could be regulated by nitric oxide. more
total:37
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Chemicon anti-B-Tubulin antibody was used to perform immunohistochemistry in order to study synaptic plasticity. more
total:5
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. 2010 to the paper
Millipore mouse monoclonal anti-MPM-2 antibody was used to carry out immunofluorescence assays in order to investigate the mechanism for Haspin-mediated histone H3 thr-3 phosphorylation regulating chromosomal passenger complex accumulation at centromeres. more
total:31
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Calbiochem anti-Bim antibody was used to perform immunoprecipitation in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
total:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-p19 antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:1
Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists. 2008 to the paper
Imran M. Khan (University of California, San Diego) rabbit polyclonal nAChR beta4 subunit antibody was used in immunohistochemistry to further characterize intrathecal (IT) delivery of nicotinic agonists.
total:54
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Santa Cruz Biotechnology anti-COX-2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more
total:1
Assessment of stromal-derived inducing activity in the generation of dopaminergic neurons from human embryonic stem cells. 2008 to the paper
Chemicon rabbit anti-Sox-1 (1:500) antibody was used in immunocytochemistry in order to study the effects of PA6 cells on the generation of dopaminergic neurons from human embryonic stem cells
total:4
The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing. 2011 to the paper
Zymed mouse anti-SF2/ASF antibody was used to perform immunoprecipitation in order to study the elongation funtion of RNA Polymerase II during co-transcriptional splicing. more
total:130
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Santa Cruz anti-Bcl-2 antibody (C-2, sc-7382, 1:500) was used to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
total:8
Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. 2012 to the paper
Immune Systems goat anti-Sox2 antibody was used to perform immunocytochemistry in order to study the mechanism that underlied termination of body axis elongation in embryos. more
total:39
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-CXCR4 was used in 3ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
total:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology MDR1 antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:1
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. 2005 to the paper
Regeneron Pharmaceuticals polyclonal anti-DDR2 antibody (R2-JM) was used in western blot to study a novel direct mechanism by which cell contact with fibrillar collagen restricts proliferation.
total:17
Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement. 2012 to the paper
Biosource International anti-FGFR-1 (pYpY653/654) antibodies were used to perform western blot and ELISA analyses in order to study the effect of the facilitation of AMPA receptor synaptic delivery on cognitive enhancement. more
total:212
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. 2012 to the paper
Abcam Caspase-3 antibody was used to perform immunohistochemistry in order to study theeffect of thiabendazole on proliferation and apoptosis of human cells. more
total:7
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Abcam anti-ABCG2 antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
total:1
The drosophila fragile X protein dFMR1 is required during early embryogenesis for pole cell formation and rapid nuclear division cycles. 2006 to the paper
Thomas Kaufman rabbit polyclonal anti-centrosomin antibody was used in immunohistochemistry to study the role of fragile X protein dFMR1 in the pole cell formation during early embryogenesis.
total:9
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
R&D Systems monoclonal anti-human HGF antibody (MoAb) was used in blocking or activating expriments to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more