leukemia
gene
reagent
sample publication
sample review
total:2
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Upstate Biotechnology anti-MLL antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:1
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 to the paper
Bethyl anti-DOT1L antibody (A300-954A or 953A) was used in ChIP assay to study the recruitment of DOT1L and the patterning of mono-, di-, and trimethylation of H3K79 under dynamic conditions in human HEK293T cells.
total:3
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Santa Cruz anti-ETO was used to perform western blot, immunoprecipitation and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
total:3
RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. 2008 to the paper
Sigma rabbit polyclonal anti-RUNX1 antibody was used in immunocytochemistry to study the interaction between E4orf6, E1B-55K, and RUNX1 and the association of the RUNX1 with centers of viral DNA and RNA synthesis. more
total:6
Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation. 2006 to the paper
Santa Cruz Biotechnology anti-FLT3(S18) antibody was used to perform western blot in order to study the mechanism of the decreased proliferation of acute myeloid leukemia (AML) cells treated with arsenic trioxide. more
total:10
Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide. 2006 to the paper
Santa Cruz Biotechnology anti-PU.1 antibody was used in western blot to determine whether ATO could target AME and related oncoproteins. more
total:5
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. 2008 to the paper
Santa Cruz anti-cyclin T1 antibody was used to perform western blot in order to study the association between ING4 and the activity of NF-kappa B molecules bound with target gene promoters. more
total:11
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz polyclonal anti-CDK9 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
total:3
Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. 2009 to the paper
Santa Cruz Biotechnology Gfi-1 (N-20) was used in coimmunoprecipitation assays in order to study the mechanism of Gfi-1 repressing CDKN2B and then encoding p15INK4B through interaction with Miz-1 more
total:130
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Santa Cruz anti-Bcl-2 antibody (C-2, sc-7382, 1:500) was used to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
total:7
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Upstate Biotechnology anti-c-Myb antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:15
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 to the paper
Santa Cruz anti-GATA-1 antibody (sc-265) was used in ChIP assay to study the recruitment of DOT1L and the patterning of mono-, di-, and trimethylation of H3K79 under dynamic conditions in human HEK293T cells. more
total:35
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Calbiochem c-Abl antibody (1:1,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
total:55
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Zymed mouse anti-ZO-1 (1:1,000) antibody was used to perform immunofluorescence in order to study the role for TRAF4, a novel phosphoinositide-binding protein, in modulating tight junctions and promoting cell migration. more
total:17
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi. 2010 to the paper
NeoMarkers anti-WT1 antibody was used to carry out western blot analysis in order to investigate the regulation of apoptosis and the oncogenic activities of WT1 by HtrA2. more
total:5
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Upstate Biotechnology anti-Meis1 antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:1
Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 to the paper
PharMingen anti-HLA-B antibody was used in flow cytometry immunophenotyping to study the function of fibromodulin which serves as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL) to enable the expansion of specific CD8+ autologous T lymphocytes
total:7
Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. 2008 to the paper
Cell Signaling Technology anti-pY-BCR-ABL antibody was used to carry out western blot analysis in order to investigate the mechanism for Lyn kinase regulating imatinib sensitivity in chronic myelogenous leukemia cells. more
total:34
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
Upstate anti-JAK2 antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
total:5
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. 2010 to the paper
BD Bioscience clathrin antibody was used to perform western blot in order to investigate internalization of ROR2 more
total:5
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. 2010 to the paper
BD Pharmingen monoclonal anti-NKG2D-allophycocyanin antibody was used to perform flow cytometry in order to show multiple CD3 Zeta-dependent receptor functions can be impaired simultaneously by pathological NKG2D ligand expression. more
total:235
Regulation of early adipose commitment by Zfp521. 2012 to the paper
Santa Cruz Biotechnology anti-MYC antibody was used to carry out western blot and immunoprecipitation assays in order to investigate the regulatory role of Zfp521 in determining the switch between the adipogenic and osteogenic lineages. more
total:11
Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. 2010 to the paper
Zymed anti-NPM antibody was used for western blot in order to investigate the role for activated Bax in the regulation of p53-dependent, transcription-independent neural precursor cell apoptosis. more
total:8
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. 2008 to the paper
Santa Cruz Biotechnology anti-HLA-A(A-18) antibody was used to perform immunohistochemistry in order to study tumor and tumor-stromal cell interactions. more
total:7
Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. 2009 to the paper
Invitrogen Purified goat IgG was used as the isotypic controls in order to identify the MHC I molecule (HLA-C) as an attachment factor in facilitating HCoV-HKU1 spike (S) mediated infection. more
total:28
Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance. 2009 to the paper
R&D systems anti-XIAP antibody was used in western blot to investigate the role of PARP-1 in the NF-kB signalling cascade induced by ionizing radiation more
total:34
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Santa Cruz Biotechnology anti-Mcl-1 antibody was used to perform western blot in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
total:212
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. 2012 to the paper
Abcam Caspase-3 antibody was used to perform immunohistochemistry in order to study theeffect of thiabendazole on proliferation and apoptosis of human cells. more
total:52
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology FAS antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
total:73
Detachment of esophageal carcinoma cells from extracellular matrix causes relocalization of death receptor 5 and apoptosis. 2009 to the paper
R&D systems anti-casp8 antibody was used to carry out western blot analysis in order to investigate the mechanism of DR5 relocalization and its effect on cell apoptosis during adhesion to detachment of EC9706 cells. more
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:79
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. 2010 to the paper
AbDSerotec PE-Cy5-conjugated anti-CD34 antibody was used to perform flow cytometry in order to study the role of the EPEC protein NleE in inhibiting NF-kappa B signaling in human dendritic cells. more
total:7
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Upstate Biotechnology anti-Bmi-1 antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
total:35
In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis. 2009 to the paper
Stressgen mouse anti-Hsp70antibody was used to perform western blot in order to show that enhancing CHIP activity is good for therapy for SCA3 or other polyQ diseases more
total:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology MDR1 antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
total:7
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-HLADR was used in 2ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
total:2
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Bethyl Laboratories anti-menin antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:1
Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. 2005 to the paper
Dr. Stephen Leeder (Mercy Children's Hospital) CYP3A5-specific polyclonal antibody was used in western blot to study the inhibition of CYP3A4 and CYP3A5 by verapamil
total:189
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 to the paper
Biosource International anti-p38 antibody was used to perform western blot in order to study the effect of NFAT5 on hyperosmolar stressed human limbal epithelial cells. more
total:34
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. 2010 to the paper
Santa Cruz Biotechnology polyclonal anti-Shp2 antibody was used to perform western blot in order to study Notch signaling auto-amplification in macrophages which was regulated by TLR and RBP-J. more
total:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Calbiochem anti-TERT antibody (1:350) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule more
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
Santa Cruz Biotechnology anti-STAT3 monoclonal antibody was used to perform western blot to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
total:79
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. 2012 to the paper
Santa Cruz Biotechnology anti-GSK3 beta antibody was used to perform western blot in order to investigate the role of GSK3-TIP60-ULK1 signaling pathway in autophagy. more
total:15
Potential therapeutic significance of increased expression of aryl hydrocarbon receptor in human gastric cancer. 2009 to the paper
Chemicon International anti-CYP 1A1 antibody (AB1258) was used in western blot to determine the functional significance of aryl hydrocarbon receptor (AhR) in gastric carcinogenesis, and to explore the possible role of AhR in gastric cancer (GC) treatment more
total:8
PTCH1 +/- dermal fibroblasts isolated from healthy skin of Gorlin syndrome patients exhibit features of carcinoma associated fibroblasts. 2009 to the paper
Abcam rabbit polyclonal anti-SDF1 alpha (alias CXCL12) antibody was used in western blot in order to demonstrate that PTCH1+/- genotype of healthy NBCCS fibroblasts is associated with basal cell carcinoma (BCC). more
total:9
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. 2009 to the paper
Sigma mouse GG-7 Fc-specific anti-human IgG antibody was used to confirm the presence of the Fc fragment of human IgG in order to illustrate that Toll-like receptor 4 (TLR4) plays a fundamental role in the sensing of LPS from Gram-negative bacteria. more
total:45
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 to the paper
Epitomics anti-MMP-9 antibody was used in immunohistochemistry to study the mechanism of protein kinase D1 for inhibiting breast tumour cell invasion. more
total:37
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion. 2009 to the paper
Santa Cruz monoclonal MMP-2 antibodies were used in western blot in order to investigate the role of matrix metalloproteinase-2 (MMP-2) gene in invasiveness and adhesion of human pancreatic cancer cell line, BxPC-3. more
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:17
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 to the paper
Epitomics anti-Notch1 antibody was used to carry out western blot analysis in order to investigate the regulation of Notch signaling and cell differentiation by mTOR signaling. more
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
total:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-p19 antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
Affinity BioReagents anti-VDR (MA1-7101, 1:400) monoclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder. more