kidney diseases
gene
reagent
sample publication
sample review
UMOD
uromodulin
total:4
Localization of broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney. 2007 to the paper
Cedarlane Laboratories anti-human Tamm-Horsfall protein (THP) antibody was used in immunohistochemistry to localize broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney more
LCN2
lipocalin 2
total:5
Lipocalin 2 promotes breast cancer progression. 2009 to the paper
R&D Systems anti-human Lcn2 antibody was used in immunohistochemistry to study the effect of Lipocalin 2 on breast cancer progression. more
FABP1
fatty acid binding protein 1
total:1
Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. 2010 to the paper
R&D Systems goat anti-human L-FABP polyclonal antibody was used to perform western blot in order to study the prognostic ability of urinary liver-type fatty acid-binding protein (L-FABP) in Acute kidney injury (AKI).
Kim-1
hepatitis A virus cellular receptor 1
total:3
Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. 2008 to the paper
Brigham and Women's Hospital and Harvard Medical School mouse monoclonal antibody against Kim-1 was used in immunohistochemistry to compare kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney. more
MYH9
myosin heavy chain 9
total:3
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. 2009 to the paper
Sigma anti-NMHC-IIA antibody was used to perform western blot in order to study the assemble of mammalian nonmuscle myosin II in live cells. more
APOL1
apolipoprotein L1
total:4
Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. 2008 to the paper
Santa Cruz Biotechnology polyclonal goat anti-apoL-I antibody (1:100) was used for western blot in order to investigate the distinct roles of apolipoprotein components in a transgenic mouse model. more
NPHS2
NPHS2 stomatin family member, podocin
total:1
An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms. 2009 to the paper
Sigma rabbit anti-Podocin antibody was used to perform immunohistochemistry in order to study the role of the universal polarity protein, aPKC Lambda.
CYP3A5
cytochrome P450 family 3 subfamily A member 5
total:1
Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. 2005 to the paper
Dr. Stephen Leeder (Mercy Children's Hospital) CYP3A5-specific polyclonal antibody was used in western blot to study the inhibition of CYP3A4 and CYP3A5 by verapamil
COL4A3
collagen type IV alpha 3 chain
total:5
Kaposi's sarcoma-associated herpesvirus activation of vascular endothelial growth factor receptor 3 alters endothelial function and enhances infection. 2005 to the paper
Santa Cruz Biotechnology goat anti-alpha3 antibody was used in western blot to study the effect of activation of vascular endothelial growth factor receptor 3 on endothelial function and infection. more
TRPC6
transient receptor potential cation channel subfamily C member 6
total:7
Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. 2006 to the paper
Santa Cruz Biotechnology TRPC6 goat polyclonal antibody was used in western blot and immunohistochemistry to study the expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. more
AGTR2
angiotensin II receptor type 2
total:6
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. 2009 to the paper
Santa Cruz rabbit anti-AT2 was used in 1:50 dilution to perform immunohistochemistry in order to show that the expression of ETB and AT1 receptor is upregulated in ischemic heart disease patients. more
Kir4.1
potassium inwardly rectifying channel subfamily J member 10
total:5
MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet. 2007 to the paper
USBiological polyclonal antibody against Kir4.1 was used in immunoprecipitation and western blot to isolate and detect Kir4.1 in human brain lysates, and in immunohistochemistry to detect aquaporin-4 distribution in human brain tissues and human glioblastoma multiforme tissues from MLC patients more
HNF1B
HNF1 homeobox B
total:5
HNF-1beta regulates transcription of the PKD modifier gene Kif12. 2009 to the paper
Santa Cruz Biotechnology anti-HNF1B antibody was used for western blot in order to investigate the role of HNF-1beta in the regulation of PKD Modifier Gene Kif12. more
CRP
C-reactive protein
total:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 to the paper
Abcam monoclonal anti-C-reactive protein (CRP) antibody was used in immunohistochemistry to study the role for activated gp130 in inflammatory hepatocellular tumours. more
ACE2
angiotensin I converting enzyme 2
total:5
Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein. 2007 to the paper
Molecular Probes anti-pyruvate dehydrogenase antibody was used to perform western blot in order to study the interaction between SARS-CoV with Bcl-XL to result in cell apoptosis. more
AHSG
alpha 2-HS glycoprotein
total:1
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe. 2010 to the paper
R&D systems anti-fetuin A antibody was used to perform western blot in order to study the role of non-directed activity-based protein profiling plays in the identification of enzymes that are either predominantly or exclusively labeled in living cells.
renin
total:2
Expression of components of the renin-angiotensin system in autosomal recessive polycystic kidney disease. 2005 to the paper
Dr. Tadashi Inagami renin antibody was used in immunohistochemistry to study the expression of components of the renin-angiotensin system in autosomal recessive polycystic kidney disease. more
ACE
angiotensin I converting enzyme
total:8
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Santa Cruz anti-ACE was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
AGT
angiotensinogen
total:6
Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy. 2008 to the paper
IgG corporation rabbit polyclonal anti-ang II serum was used in immunohistochemistry in order to study the glomerular AGT's expression and its correlation with expression of other RAS components more
AGTR1
angiotensin II receptor type 1
total:9
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. 2009 to the paper
Santa Cruz rabbit anti-AT1 was used to perform immunohistochemistry in order to show that the expression of ETB and AT1 receptor is upregulated in ischemic heart disease patients. more
Pax2
paired box 2
total:8
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. 2009 to the paper
Abcam polyclonal PAX 2 antibody was used in western blot in order to demostrate the expression of PAX 5 and the regulation for c-Met transcription in small cell lung cancer. more
MRP2
ATP binding cassette subfamily C member 2
total:7
ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal ABCC2 antibody (H-300) and goat polyclonal ABCC2 antibody (H-17) were used in immunocytochemistry (1:400) to study its localization in the nuclear membrane of ovarian carcinomas and its correlation with resistance to cisplatin and clinical outcome. more
osteoprotegerin
TNF receptor superfamily member 11b
total:2
Calcification of human vascular smooth muscle cells: associations with osteoprotegerin expression and acceleration by high-dose insulin. 2007 to the paper
R&D Systems sandwich ELISA kit in which mouse anti-human OPG was employed as capture antibody and a biotinylated goat anti-human OPG used for detection to determine the concentration of OPG in the conditional medium of human vascular smooth muscle cells. more
MCP-1
C-C motif chemokine ligand 2
total:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 to the paper
Santa Cruz anti-MCP-1 antibody was used to perform immunohistochemistry in order to study the effect of MCP1 and CD40 ligation on VEGF production. more
visfatin
nicotinamide phosphoribosyltransferase
total:1
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 2010 to the paper
Bethyl Laboratories NAMPT antibody was used for western blot in order to investigate the role of DBC1 in the regulation of SIRT1 activity and high-fat diet induced liver steatosis in mice.
TNNT2
troponin T2, cardiac type
total:3
Functional cardiomyocytes derived from human induced pluripotent stem cells. 2009 to the paper
Thermo Scientific monoclonal anti-cTnT was used to perform immunolabeling in order to study functional cardiomyocytes derived from human induced pluripotent stem cells. more
PTX3
pentraxin 3
total:2
Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons. 2006 to the paper
Axxora PTX3 antibody (1:500) was used in western blot to demonstrate that dendritic A-type K+ channels regulate action potential backpropagation and the induction of specific forms of synaptic plasticity. more
ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13
total:1
Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion. 2008 to the paper
Santa Cruz Biotechnology TTP antibody was used in immunocytochemistry in order to study the mechanism of persistent translation arrest
TGF-beta1
transforming growth factor beta 1
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
VDR
vitamin D receptor
total:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
Affinity BioReagents anti-VDR (MA1-7101, 1:400) monoclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder. more
ABCB1
ATP binding cassette subfamily B member 1
total:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology MDR1 antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
RANKL
TNF superfamily member 11
total:7
Differential expression of RANK, RANK-L, and osteoprotegerin by synovial fluid neutrophils from patients with rheumatoid arthritis and by healthy human blood neutrophils. 2007 to the paper
R&D Systems monoclonal anti-human OPG antibody was used in elisa to study differential expression of RANK, RANK-L, and osteoprotegerin from patients with rheumatoid arthritis. more
connective tissue growth factor
cellular communication network factor 2
total:11
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Santa Cruz Biotechnologies CTGF antibody (1:2,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
MMP-2
matrix metallopeptidase 2
total:37
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion. 2009 to the paper
Santa Cruz monoclonal MMP-2 antibodies were used in western blot in order to investigate the role of matrix metalloproteinase-2 (MMP-2) gene in invasiveness and adhesion of human pancreatic cancer cell line, BxPC-3. more
endothelin 1
total:9
Expression of endothelial nitric oxide synthase and endothelin-1 in skin tissue from amputated limbs of patients with complex regional pain syndrome. 2008 to the paper
R&D systems rat anti-human ET-1 antibody (3G10) was used in immunohistochemistry to examine the distribution of eNOS and ET-1 in relation to vascular density represented by the endothelial marker CD31-immunoreactivity in skin tissue from amputated limbs of patients with CRPS. more
IL-6
interleukin 6
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
IL-18
interleukin 18
total:7
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. 2005 to the paper
BioSource Europe SA anti-IL-18 antibody (which was in ELISA kit) was used in venous blood samples from human and in ELISA to study the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. more