k562 cells
gene
reagent
sample publication
sample review
total:7
Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. 2008 to the paper
Cell Signaling Technology anti-pY-BCR-ABL antibody was used to carry out western blot analysis in order to investigate the mechanism for Lyn kinase regulating imatinib sensitivity in chronic myelogenous leukemia cells. more
total:1
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. 2011 to the paper
Invitrogen FITC-conjugated monoclonal anti-HbF was used to perform flow cytometry in order to show that sickle cell disease could be corrected by BCL11A inactivation to keep human fetal hemoglobin expression.
total:35
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Calbiochem c-Abl antibody (1:1,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
total:15
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 to the paper
Santa Cruz anti-GATA-1 antibody (sc-265) was used in ChIP assay to study the recruitment of DOT1L and the patterning of mono-, di-, and trimethylation of H3K79 under dynamic conditions in human HEK293T cells. more
total:17
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi. 2010 to the paper
NeoMarkers anti-WT1 antibody was used to carry out western blot analysis in order to investigate the regulation of apoptosis and the oncogenic activities of WT1 by HtrA2. more
total:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology MDR1 antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:7
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Upstate Biotechnology anti-c-Myb antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:1
Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm. 2009 to the paper
Sigma anti-LRP16 antibody was used in western blot in order to investigate the mechanism of how the cytoplasmic intermediate filament protein-keratin 18 regulates estrogen receptor alpha-mediated signaling in cytoplasm.
total:3
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Santa Cruz anti-ETO was used to perform western blot, immunoprecipitation and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
total:3
RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. 2008 to the paper
Sigma rabbit polyclonal anti-RUNX1 antibody was used in immunocytochemistry to study the interaction between E4orf6, E1B-55K, and RUNX1 and the association of the RUNX1 with centers of viral DNA and RNA synthesis. more
total:21
C/EBPalpha or C/EBPalpha oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-kappaB p50 bound to the bcl-2 and FLIP gene promoters. 2009 to the paper
Affinity Bioreagents mouse anti-C/EBPa antibody was used to carry out immunoprecipitation assay and western blot analysis in order to investigate the mechanism for oncoprotein C/EBPa cooperated with NF-kB p50 to inhibit apoptosis. more
total:2
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. 2010 to the paper
Beckman Coulter monoclonal anti-NKp30-PE antibody was used to perform flow cytometry in order to show multiple CD3 Zeta-dependent receptor functions were impaired simultaneously by pathological NKG2D ligand expression. more
total:5
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. 2010 to the paper
BD Pharmingen monoclonal anti-NKG2D-allophycocyanin antibody was used to perform flow cytometry in order to show multiple CD3 Zeta-dependent receptor functions can be impaired simultaneously by pathological NKG2D ligand expression. more
total:7
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Abcam anti-ABCG2 antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
total:235
Regulation of early adipose commitment by Zfp521. 2012 to the paper
Santa Cruz Biotechnology anti-MYC antibody was used to carry out western blot and immunoprecipitation assays in order to investigate the regulatory role of Zfp521 in determining the switch between the adipogenic and osteogenic lineages. more
total:5
Increased expression of stathmin in eutopic endometrium of patients with endometriosis. 2010 to the paper
Abcam polyclonal rabbit anti-human stathmin antibody was used to perform western blot and immunohistochemistry in order to study the overexpression of stathmin protein in eutopic endometrium of patients with endometriosis. more
total:2
Tal1/SCL binding to pericentromeric DNA represses transcription. 2005 to the paper
Geneka Biotechnology Tal1/SCL-specific antibody was used in immunoprecipitation to isolate DNA-Tal1-SCL complexes formed in vitro by incubating genomic DNA with human K562 nuclear extract, in CHIP assay to investigate the association between Tal1/SCL and EEGS in human K562 cells, and in western blot to detect Tal1/SCL in K562 more
total:51
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. 2010 to the paper
Santa Cruz Biotechnology anti-STAT5 antibody was used to perform immunoprecipitation in order to study the interaction between MUC1-C and STAT1 pathway in poor prognosis human breast cancers. more
total:11
Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. 2008 to the paper
Santa Cruz mouse anti-SHIP1 was used to perform western blot in order to show that IRAK-1 blockade is important for tolerance of human DCs induced by TLR2 and TLR4 stimulation. more
total:34
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
Upstate anti-JAK2 antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
total:10
Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide. 2006 to the paper
Santa Cruz Biotechnology anti-PU.1 antibody was used in western blot to determine whether ATO could target AME and related oncoproteins. more
total:130
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Santa Cruz anti-Bcl-2 antibody (C-2, sc-7382, 1:500) was used to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
total:58
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-CREB1 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:3
NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. 2010 to the paper
Beckman Coulter monoclonal anti-NKp46-PE antibody was used to perform flow cytometry in order to show multiple CD3 Zeta-dependent receptor functions were impaired simultaneously by pathological NKG2D ligand expression. more
total:2
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. 2009 to the paper
eBioscience, CD244 antibody was used for flow cytometry in order to clarify that ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. more
total:9
Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. 2011 to the paper
Biolegend anti-perforin antibody was used to perform immunocytochemistry in order to study the secretion of natural killer cell lytic granule at the immune synapse. more
total:212
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. 2012 to the paper
Abcam Caspase-3 antibody was used to perform immunohistochemistry in order to study theeffect of thiabendazole on proliferation and apoptosis of human cells. more
total:23
CBFbeta is critical for AML1-ETO and TEL-AML1 activity. 2009 to the paper
eBioscience allophycocyanin (APC), phycoerythrin (PE), or PerCPcy5.5 conjugated anti Mac-1 (clone M1/70) antibody was used in flow cytometry in order to determine whether CBFbeta is required for AML1-ETO and TEL-AML1 activity more
total:6
Proteomic and genomic analysis of PITX2 interacting and regulating networks. 2009 to the paper
Epitomics anti-hnRNP K antibody was used to perform western blot in order to find out the PITX2 interacting and regulating networks. more
total:8
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. 2008 to the paper
Santa Cruz Biotechnology anti-HLA-A(A-18) antibody was used to perform immunohistochemistry in order to study tumor and tumor-stromal cell interactions. more
total:10
Unique early gene expression patterns in human adult-to-adult living donor liver grafts compared to deceased donor grafts. 2009 to the paper
Santa Cruz Biotech SOCS3 antibody was used in immunohistochemistry to study the distinctive differences at the molecular level between deceased donor (DD) and living donor (LD) liver grafts more
total:2
Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis. 2009 to the paper
Upstate anti-PRMT1 antibody was used to perform western blot in order to study the functions of protein arginine methyltransferase 1. more
total:16
CK2beta is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation. 2009 to the paper
Santa Cruz anti-FLIP antibody was used to perform immunohistochemistry in order to show the role of CK2B in apoptosis resistance and cell proliferation in endometrial carcinoma. more
total:10
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. 2010 to the paper
Santa Cruz anti-phos-CaMKII antibody was used to perform western blot in order to study the role of cGMP-dependent protein kinase and RGS2 in local antihypertrophic effects of cardiac atrial natriuretic peptide. more
total:2
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 to the paper
Bethyl rabbit anti-WDR5 antibody was used to carry out RNA immunoprecipitation assays in order to investigate the role for long intergenic noncoding RNAs as scaffolds to regulate histone modification complexes and gene expression. more
total:6
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. 2013 to the paper
Abcam anti-YB-1 antibody was used to perform western blotting in order to determine the subcellular distribution of the hnRNP-Q. more
total:27
Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. 2009 to the paper
BD Biosciences monoclonal mouse anti-phospho-focal adhesion kinase (FAK) antibody was used in immunocytochemistry to study the role of supervillin (SV) in the function of tumor cell actin-rich protrusions. more
total:102
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. 2011 to the paper
Santa Cruz anti-BAX was used to perform western blot in order to show that chemotherapy is efficient for patients with high mitochondrial priming more
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
total:9
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
Santa Cruz Biotechnology anti-EpoR antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
total:4
Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-?-TAK1-dependent mechanism. 2013 to the paper
Abcam HIPK2 antibody was used to perform ChIP in order to investigate the mechanism of the control of angiogenesis by transcriptional corepressors HIPK1 and HIPK2. more
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:46
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Beckman-coulter PE-conjugated anti-CD11b was used to perform flow cytometry in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
total:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Calbiochem anti-TERT antibody (1:350) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule more
total:19
An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-FYN antibody was used for immunoprecipitation in order to study the effect of DC ehrlichiae on cell signaling, transcriptional regulation, and vesicle trafficking. more
total:3
ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. 2010 to the paper
Abcam KAP1 antibody (#ab3831) was used to perform ChIP assays in order to clarify that a KRAB domain-containing ZNF is involved in recruitment of the KAP1 and SETDB1 to specific regions of the human genome. more
total:7
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. 2005 to the paper
BioSource Europe SA anti-IL-18 antibody (which was in ELISA kit) was used in venous blood samples from human and in ELISA to study the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. more
total:20
Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors. 2009 to the paper
Santa Cruz anti-Lyn 44 antibody was used to perform western blot in order to study the roles of the lipid raft-dependent Fc secre tRI ubiquitination in the regulation of receptor endocytosis. more
total:21
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Bethyl Laboratories anti-p73 was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
total:100
Plasma membrane contributes to the formation of pre-autophagosomal structures. 2010 to the paper
Abcam anti-AP1-A1 antibody was used to perform western blot in order to study the role of plasma membrane in the formation of preautophagosomal structures. more
total:70
Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. 2010 to the paper
Santa Cruz anti-Sp1 antibody was used to perform ChIP assay in order to study the regulatory function of Sp1 and KLF15 on basal transcription of the human LRP5 gene. more
total:1
RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. 2008 to the paper
Active Motif rabbit polyclonal anti-RUNX3 antibody was used in immunocytochemistry to study the interaction between E4orf6, E1B-55K, and RUNX1 and the association of the RUNX1 with centers of viral DNA and RNA synthesis.
total:14
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. 2010 to the paper
BD Biosciences anti-CD62L antibody was used in flow cytometry in order to investigate the roles of Fas ligand and TRAIL in the regulation of murine thymic graft-versus-host disease. more
total:68
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-HSP90 was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
total:6
Silencing of herg gene by shRNA inhibits SH-SY5Y cell growth in vitro and in vivo. 2008 to the paper
Santa Cruz anti-HERG antibody (sc-15968, 1:1000) was used to perform western blot in order to study the important role of herg in regulating the growth and proliferation of SH-SY5Y cells. more
total:7
Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo. 2009 to the paper
R&D Systems anti-human IL-15R antibody was used to perform enzyme-linked immunosorbent assays in order to investigate the relationship between IL-15R and specific immune response. more
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
Santa Cruz Biotechnology anti-STAT3 monoclonal antibody was used to perform western blot to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
total:31
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Calbiochem anti-Bim antibody was used to perform immunoprecipitation in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
total:34
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Santa Cruz Biotechnology anti-Mcl-1 antibody was used to perform western blot in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
total:7
Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. 2009 to the paper
eBioscience antibodies against alpha4beta1 were used in immunohistochemistry to investigate MuPAR and plasmin in the regulation of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and HSCs. more
total:2
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Upstate Biotechnology anti-MLL antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:28
Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression. 2010 to the paper
Santa Cruz Biotechnology mouse monoclonal integrin beta3 antibody (1:1000) was used in western blot in order to study the role of activated state of p42/44 and p38 in MMP-13 expression. more
total:2
eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. 2008 to the paper
Abcam rabbit anti-KLF4 antibody 1:15,000 was used for western blot in order to investigate the role of eIF4GI in the regulation of cell proliferation and autophagy. more