glioma
gene
reagent
sample publication
sample review
IDH1
isocitrate dehydrogenase (NADP(+)) 1
total:1
Quiescent fibroblasts exhibit high metabolic activity. 2010 to the paper
Lifespan Biosciences anti-IDH1 antibody was used to perform western blot in order to study the function of quiescent fibroblasts.
RAM
CCDC26 long non-coding RNA
LL5A
pleckstrin homology like domain family B member 1
RTEL1
regulator of telomere elongation helicase 1
total:1
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-RTEL1 was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19.
ERN1
endoplasmic reticulum to nucleus signaling 1
total:2
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. 2006 to the paper
Santa Cruz Biotechnology anti-IRE1alpha antibody was used in western blot to study the mechanism by which ER stress activates NF-kappaB and its role in regulation of ER stress-induced cell death in human cells. more
TSLL1
cell adhesion molecule 3
total:1
Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. 2005 to the paper
Immunex antibody anti-hNecl1 (M170) was used in flow cytometry to identify a subset of T-cell zone dendritic cells by nectin-like protein 2
SEPTIN7
septin 7
total:2
Planar cell polarity acts through septins to control collective cell movement and ciliogenesis. 2010 to the paper
Santa Cruz Biotechnology anti-septin7 antibody was used to carry out immunofluorescence assays in order to investigate the role for planar cell polarity protein Fritz regulating collective cell movement and ciliogenesis by controling septin localization. more
LRIG3
leucine rich repeats and immunoglobulin like domains 3
doublecortin
total:6
Retinoic acid functions as a key GABAergic differentiation signal in the basal ganglia. 2011 to the paper
Millipore guinea pig anti-DCX antibody(1:500)was used to perform immunocytochemistry in order to investigate the role of retinoic acid in generation of GABAergic neurons in the basal ganglia. more
CD133
prominin 1
total:19
A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. 2009 to the paper
Abcam polyclonal anti-CD133 antibody was used for western blot in order to identify the role of MT1-MMP for the regulation of COX-2 expression in CD133 (+) U87 glioblastoma cells. more
NR2E1
nuclear receptor subfamily 2 group E member 1
EGFR
epidermal growth factor receptor
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
TERT
telomerase reverse transcriptase
total:10
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Calbiochem anti-TERT antibody (1:350) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule more
PTEN
phosphatase and tensin homolog
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
histone H3
H3.3 histone A
total:12
Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. 2010 to the paper
Santa Cruz Biotechnology anti-Crem antibody was used to perform western blot and immunoprecipitation in order to study the role of Jmjd1a-controlled epigenetic histone modifications in Crem-regulated gene expression and spermatogenesis. more
Akt
AKT serine/threonine kinase 1
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
EGF
epidermal growth factor
total:9
Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors. 2008 to the paper
Santa Cruz Biotechnology rabbit anti-EGF antibody was used in immunohistochemistry to study whether the expression of tyrosine kinase growth factor receptors is constant or varies between and within individual colon cancer neoplasms. more
OLIG2
oligodendrocyte transcription factor 2
total:5
Transforming fusions of FGFR and TACC genes in human glioblastoma. 2012 to the paper
IBL rabbit anti-Olig2 was used at 1:200 to perform immunohistochemistry and immunocytochemistry in order to show that FGFR-TACC fusion happened in specific GBM patients. more
p53
tumor protein p53
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
FABP7
fatty acid binding protein 7
total:2
Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits. 2008 to the paper
Chemicon polyclonal rabbit anti-BLBP antibody (AB9558) was used in immunohistochemistry to study what happens in the cerebellar cortex of peripuberal rabbits by using endogenous and exogenously-administered cell proliferation antigens in association with a cohort of typical markers for neurogenesis. more
SOX2
SRY-box transcription factor 2
total:8
Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. 2012 to the paper
Immune Systems goat anti-Sox2 antibody was used to perform immunocytochemistry in order to study the mechanism that underlied termination of body axis elongation in embryos. more
MIR21
microRNA 21
NANOG
Nanog homeobox
total:6
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Abcam anti-Nanog antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
STAT3
signal transducer and activator of transcription 3
total:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
Santa Cruz Biotechnology anti-STAT3 monoclonal antibody was used to perform western blot to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
TRAIL
TNF superfamily member 10
total:6
Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. 2005 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-TRAIL antibody was used in western blot to investigate the role of human BVR in sodium arsenite (As) mediated induction of HO-1 and in cytoprotection against apoptosis by small interference RNA-mediated gene silencing. more
CHI3L1
chitinase 3 like 1
total:2
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. 2008 to the paper
R&D Systems goat polyclonal anti-human chitinase 3-like 1 antibody was used in western blot and immunohistochemistry to study the role for YKL-40 in modulating the biological activity of basic fibroblast growth factor. more
SPARC
secreted protein acidic and cysteine rich
total:11
Aberrant promoter methylation of SPARC in ovarian cancer. 2009 to the paper
Santa Cruz Biotechnology anti-human SPARC antibody was used for western blot and immunohistochemistry in order to study the role of SPARC in therapeutic process for ovarian cancer. more
nestin
total:24
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. 2012 to the paper
Millipore anti-human nestin antibody was used to perform immunohistochemistry in order to study NKCC1 modulation of glioma cell migration. more
aquaporin 4
total:10
Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains. 2008 to the paper
Santa Cruz Biotechnology anti-AQP4 antibody (H-80) was used in immunohistochemistry to investigate AQP4 expression in cerebral cortex from AD patients. more
ING4
inhibitor of growth family member 4
total:3
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. 2008 to the paper
Abcam anti-ING4 antibody was used to perform western blot in order to study the association between ING4 and the activity of NF-kappa B molecules bound with target gene promoters. more
NODAL
nodal growth differentiation factor
total:1
A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization. 2008 to the paper
Santa Cruz Biotechnology anti-Nodal antibody was used in immunohistochemistry to identify these TGFbeta family members in human endometrium, and to determine whether they are involved in human decidualization.
IGFBP2
insulin like growth factor binding protein 2
total:2
A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells. 2005 to the paper
Santa Cruz Biotechnology IGFBP2 antibody was used in western blot and immunohistochemistry to demonstrate that dexamethasone alters proteolytic regulation of IGFBP-2 in ileal crypt cells. more
BMI1
BMI1 proto-oncogene, polycomb ring finger
total:7
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Upstate Biotechnology anti-Bmi-1 antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
uPAR
plasminogen activator, urokinase receptor
total:13
Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation. 2009 to the paper
Abcam rabbit anti-uPAR antibody was used to carry out immunofluorescence assays in order to investigate the association for increased expression of urokinase plasminogen activator and megakaryocyte differentiation in Quebec platelet disorder. more
Sp1
Sp1 transcription factor
total:70
Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. 2010 to the paper
Santa Cruz anti-Sp1 antibody was used to perform ChIP assay in order to study the regulatory function of Sp1 and KLF15 on basal transcription of the human LRP5 gene. more
FAK
protein tyrosine kinase 2
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
ADAM17
ADAM metallopeptidase domain 17
total:13
TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. 2008 to the paper
Santa Cruz Biotechnology anti-TACE antibody was used to perform Western Blot in order to show that TACE has a inhibitory role in EGFR axis in colorectal cancer. more
EGLN3
egl-9 family hypoxia inducible factor 3
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD3 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
integrin alpha v
integrin subunit alpha V
total:24
TGFBI expression is associated with a better response to chemotherapy in NSCLC. 2010 to the paper
Chemicon Interational anti-integrin alphavbeta3 monoclonal was used to perform flow cytometry in order to determine if this integrin influences TGFBI-mediated NSCLC cell susceptibility to chemotherapy. more
RECK
reversion inducing cysteine rich protein with kazal motifs
total:1
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization. 2009 to the paper
MBL International Corp. mouse anti-human RECK antibody was used in flow cytometry in order to study the role of MT1-MMP and RECK for the motility, adhesion, and mobilization of human hematopoietic progenitor cells.
osteopontin
secreted phosphoprotein 1
total:12
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Calbiochem anti-osteopontin antibody (1:100) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
PDGFA
platelet derived growth factor subunit A
total:5
Antiangiogenic characteristics of astrocytes from optic nerve heads with primary open-angle glaucoma. 2008 to the paper
Santa Cruz Biotechnology anti-PDGF-A polyclonal antibody was used to perform western blot in order to study the role of astrocytes on angiogenesis. more
MIR10B
microRNA 10b
EPAS1
endothelial PAS domain protein 1
total:9
Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha. 2010 to the paper
Novus Biologicals HIF2alpha antibody was used for ChIP assays in order to study HIF-binding and Ets-binding motifs on the PTPRZ1 promoter and show that PTPRZ1 can be activated by HIF-2. more
tie-2
TEK receptor tyrosine kinase
total:11
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Flk-1 antibody was used in western blot in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
RIP
receptor interacting serine/threonine kinase 1
total:9
Repression of NF-kappaB and activation of AP-1 enhance apoptosis in prostate cancer cells. 2009 to the paper
Santa Cruz Biotechnology anti-RIP antibody was used in western blot to study the effect of repression of NF-kB and activation of AP-1 on apoptosis in prostate cancer cells. more
HIF-1 alpha
hypoxia inducible factor 1 subunit alpha
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
PDGFB
platelet derived growth factor subunit B
total:5
Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors. 2008 to the paper
Santa Cruz Biotechnology rabbit anti-PDGF-B antibody was used in immunohistochemistry to study whether the expression of tyrosine kinase growth factor receptors is constant or varies between and within individual colon cancer neoplasms. more
MIR27A
microRNA 27a
CDKN2B
cyclin dependent kinase inhibitor 2B
total:1
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 to the paper
Santa Cruz anti-p15 was used to perform western blot in order to show the role of cyclin K and cyclin D1b in multiple myeloma.
EGLN1
egl-9 family hypoxia inducible factor 1
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD2 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
PDGFR alpha
platelet derived growth factor receptor alpha
total:14
PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. 2008 to the paper
Santa Cruz Biotechnology anti-PDGFRA antibody was used to perform Western Blot and immunohistochemistry in order to prove that the metastatic behavior of human colorectal cancer correlates with PDGFRalpha/beta expression. more
p16
cyclin dependent kinase inhibitor 2A
total:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-p19 antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
ICAT
catenin beta interacting protein 1
total:12
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. 2013 to the paper
Millipore anti-active-beta-catenin antibody was used to perform immunohistochemistry to study the role of Gcm1 and Fzd5 in regulating trophoblast differentiation and sites of chorionic branching morphogenesis. more
VEGFR-2
kinase insert domain receptor
total:35
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.. 2010 to the paper
Santa Cruz anti-Flk-1 antibody was used to perform immunoprecipitation in order to reveal the critical role of prorenin receptor and vacuolar H+-ATPase-mediated acidification in Wnt signaling. more
CREB
cAMP responsive element binding protein 1
total:58
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-CREB1 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
BECN1
beclin 1
total:8
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. 2012 to the paper
BD Pharmingen anti-Beclin 1 antibody was used to perform western blot in order to show that p53-dependent cell proliferation and survival could be regulated by atg7. more
DR5
TNF receptor superfamily member 10b
total:15
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. 2010 to the paper
eBioscience rabbit polyclonal anti-DR5 antibody was used in flow cytometry in order to investigate the roles of Fas ligand and TRAIL in the regulation of murine thymic graft-versus-host disease. more
FOXM1
forkhead box M1
total:5
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. 2010 to the paper
Millipore mouse monoclonal anti-MPM-2 antibody was used to carry out immunofluorescence assays in order to investigate the mechanism for Haspin-mediated histone H3 thr-3 phosphorylation regulating chromosomal passenger complex accumulation at centromeres. more
Dnmt1
DNA methyltransferase 1
total:12
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-DNMT1 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
MIR34A
microRNA 34a
Notch1
notch receptor 1
total:17
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 to the paper
Epitomics anti-Notch1 antibody was used to carry out western blot analysis in order to investigate the regulation of Notch signaling and cell differentiation by mTOR signaling. more
TET2
tet methylcytosine dioxygenase 2