genomic instability
gene
reagent
sample publication
sample review
total:10
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination. 2008 to the paper
Novus anti-BLM antibody (NB100-161) was used to perform immunoprecipitation and western blot in order to study the formation of BLM-53BP1-RAD51 complex. more
total:2
The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. 2010 to the paper
Acbam anti-MCM6 antibody was used for western blot in order to investigate the role of ETG1 in the regulation of endogenous DNA stress. more
total:3
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. 2012 to the paper
Abcam anti-SAE2 was used to perform western blot in order to show that Myc-dependent cancer needs SUMOylation for tumorigenesis. more
total:1
Meningiomas exhibit loss of heterozygosity of the APC gene. 2008 to the paper
Calbiochem monoclonal mouse anti-human APC-1 antibody (1:50) was used to perform immunohistochemistry in order to study the adenomatous polyposis coli (APC) gene's loss of heterozygosity in meningiomas.
total:19
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Novus Biologicals polyclonal anti-53BP1 was used to perform immunocytochemistry in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
total:24
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Santa Cruz human ATR antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
total:84
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. 2011 to the paper
Santa Cruz anti-PCNA was used to perform western blot in order to show that RHINO is important for ATR activation during DNA damage responses. more
total:20
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Calbiochem anti-Rad51 was used to perform immunocytochemistry in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:5
Orc1 controls centriole and centrosome copy number in human cells. 2009 to the paper
Santa Cruz Biotechnology rabbit pAb anti-MCM3 antibody was used for western blot in order to demonstrate that the copy numbers of centriole and centrosome were regulated by Orc1 in human cells. more
total:1
The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. 2010 to the paper
Acbam anti-MCM4 antibody was used for western blot in order to investigate the role of the ETG1 in the regulation of endogenous DNA stress.
total:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Calbiochem anti-BRCA1 monoclonal antibody was used to perform immunoprecipitation in order to study the function of apicobasal polarity and regulation of stem cell in breast cancer more
total:1
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. 2009 to the paper
Bethyl anti-Rap80 antibody (BL2839) was used in western blot and immunoprecipitation to study the role for NBA1 in IR resistance, cell cycle regulation, and the recruitment of BRCA1 to sites of DNA damage.
total:59
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. 2010 to the paper
Santa Cruz anti-Chk1 monoclonal antibody was used to perform western blot in order to study the interactions of ATR and ATRIP in gene expression and production of virus during HSV-1 infection. more
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
total:29
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Plk1 antibody was used to perform immunoprecipitation in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
total:2
ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function. 2009 to the paper
Cascade Bioscience anti-FANCA antibody was used in western blot in order to demonstrate that phosphorylation of FANCA on serine 1449 after DNA damage is downstream of ATR and is functionally important in the FA pathway. more
total:1
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. 2009 to the paper
Abcam POLH polyclonal antibody was used in western blot to study the role of TLS DNA polymerases eta and kappa in the regulation of naturally occurring DNA structures in human cancer cells.
total:6
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Mcm7 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
total:6
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Santa Cruz Biotechnology monoclonal anti-p55CDC antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
total:2
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Bethyl Laboratories anti-FANCJ was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
total:1
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. 2011 to the paper
Bethyl anti-Rad18 was used to perform western blot in order to show that RHINO is important for ATR activation during DNA damage responses.
total:9
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 to the paper
Novus Biological anti-FANCD2 polyclonal antibody was used to carry out immunofluorescence assays in order to investigate the role for FAN1 in promoting DNA interstrand cross-link repair by mono-ubiquitylating FANCI-FANCD2 complex. more
total:28
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Novus NBS1 antibody was used to perform immunofluorescence assay in order to study the requirement of RSFI in DSB repair. more
total:8
Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. 2006 to the paper
BD Biosciences antibody to total Mcm2 was used in western blot to examine the levels of total Mcm2 in HeLa cells. more
total:3
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. 2010 to the paper
Santa Cruz Biotechnology anti-ATRX was used to perform western-blot and immunoprecipitation in order to demonstrate that DAXX functions as a histone chaperone involved in the replication-independent deposition of H3.3. more
total:1
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-RTEL1 was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19.
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:4
The C-terminal domain of Cernunnos/XLF is dispensable for DNA repair in vivo. 2009 to the paper
Abcam DNA ligase IV antibody was used for western blot in order to investigate the role of the c-terminal domain of cernunnos/XLF in the regulation of DNA repair in vivo. more
total:22
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Life Technologies anti-Ku80 antibody was used to perform immunoprecipitation and immunofluorescence in order to study IRF-3-dependent innate immunity. more
total:6
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. 2007 to the paper
Zymed rabbit anti-Fhit polyclonal antibody(1:1000) was used to perform western blot in order to study the function of miR-29 family to restore normal patterns of DNA methylation in lung cancer. more
total:23
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Rockland anti-pT232 Aurora B was used to perform immunocytochemistry in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
total:11
Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors. 2010 to the paper
Immuquest anti-MAD2 antibody was used in western blot in order to investigate the different expression levels of spindle proteins in the testicular germ cell tumors. more
total:19
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.. 2009 to the paper
Calbiochem rabbit polyclonal Mre11 antibody was used to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2. more
total:1
Cell-cell contact globally activates microRNA biogenesis. 2009 to the paper
Upstate anti-Ago antibody was used to perform western blot in order to study the association between the cell-cell contact and microRNA biogenesis.
total:62
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore Gamma-H2AX antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more