endothelial cells
gene
reagent
sample publication
sample review
VEGF
vascular endothelial growth factor A
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
eNOS
nitric oxide synthase 3
total:36
Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. 2009 to the paper
Upstate Laboratories anti-eNOS antibody was used for western blot in order to investigate the role of purinergic in the regulation of endothelial nitric oxide synthase activity in endothelial cells. more
VEGFR-2
kinase insert domain receptor
total:35
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.. 2010 to the paper
Santa Cruz anti-Flk-1 antibody was used to perform immunoprecipitation in order to reveal the critical role of prorenin receptor and vacuolar H+-ATPase-mediated acidification in Wnt signaling. more
VE cadherin
cadherin 5
total:19
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
eBioscience anti-CD144 antibody was used in immunohistochemistry in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
ICAM-1
intercellular adhesion molecule 1
total:30
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy. 2011 to the paper
R&D systems anti-ICAM-1 antibody was used to perform immunocytochemistry in order to study the remodelling of cortical actin at natural killer cell immune synapses. more
E-selectin
selectin E
total:5
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. 2008 to the paper
R&D monoclonal anti-E-selectin antibody (BBIG-E4) was used in immunohistochemistry to determine whether the heterogeneous clinical response to tumour necrosis factor (TNF) alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNFalpha expression in the synovium before initiation of treatment. more
VCAM-1
vascular cell adhesion molecule 1
total:19
The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways. 2009 to the paper
Immunotech anti-VCAM-1 antibody was used in blocking or activating expriments to study the role for prostate specific membrane antigen in regulating the expression of IL-6 and CCL5 in prostate tumour cells. more
endothelin 1
total:9
Expression of endothelial nitric oxide synthase and endothelin-1 in skin tissue from amputated limbs of patients with complex regional pain syndrome. 2008 to the paper
R&D systems rat anti-human ET-1 antibody (3G10) was used in immunohistochemistry to examine the distribution of eNOS and ET-1 in relation to vascular density represented by the endothelial marker CD31-immunoreactivity in skin tissue from amputated limbs of patients with CRPS. more
tie-2
TEK receptor tyrosine kinase
total:11
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Flk-1 antibody was used in western blot in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
von Willebrand factor
total:32
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. 2009 to the paper
Serotec sheep anti-VWF was used to test von Willebrand factor (VWF) in order to research Rab27a and MyRIP's regulation to the amount and multimeric state of VWF released from endothelial cells. more
angiopoietin 2
total:5
Expression of angiopoietin-2 is correlated with vascularization and tumor size in human colorectal adenocarcinoma. 2007 to the paper
Santa Cruz Biotechnology rabbit-derived polyclonal Ang-1 antibody was used in immunohistochemistry to study angiopoietin-2 expression in human colorectal adenocarcinoma more
Flt-1
fms related receptor tyrosine kinase 1
total:16
The association of vascular endothelial growth factor receptor-1 with the risk of cancer progression following radical prostatectomy. 2008 to the paper
R&D Systems goat anti-human VEGFR-1 polyclonal antibody (catalog number: AF321) was used to perform immunochemistry assays in order to demonstrate that VEGFR-1 expression is not related to the risk of cancer progression following radical prostatectomy. more
PECAM 1
platelet and endothelial cell adhesion molecule 1
total:125
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. 2012 to the paper
Millipore anti-mouse CD31 antibody was used to perform immunohistochemistry in order to study the inhibition of antifungal drug thiabendazole to tumor growth in a mouse xenograft model. more
tissue factor
coagulation factor III, tissue factor
total:5
Versican G3 domain promotes blood coagulation through suppressing the activity of tissue factor pathway inhibitor-1. 2006 to the paper
BD Biosciences tissue factor antibody (CD142, clone number HTF-1) was used in western blot to detect its expression in culture medium and cell lysate from versican G3- or vector-transfected astrocytoma cell line U87 more
FGF-2
fibroblast growth factor 2
total:20
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. 2009 to the paper
Chemicon rabbit polyclonal anti-FGF2 antibody was used in western blot to study the role for endothelial-derived FGF2 in the progression of pulmonary hypertension in humans and rodents. more
DLL4
delta like canonical Notch ligand 4
total:1
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. 2007 to the paper
I. B. Lobov (Regeneron Pharmaceuticals) Dll4 antibody was used in immunohistochemistry to study the role of Dll4 during vascular growth and differentiation.
thrombospondin 1
total:20
Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling. 2009 to the paper
Acbam mouse monoclonal antibody against human and mouse thrombospondin-1 was used in immunohistochemistry to investigate the role of transforming growth factor Beta signaling in the regulation of tumor growth. more
tissue factor pathway inhibitor
total:2
Versican G3 domain promotes blood coagulation through suppressing the activity of tissue factor pathway inhibitor-1. 2006 to the paper
American Diagnostica Inc mouse anti-human TFPI monoclonal antibody and rabbit anti-human TFPI polyclonal antibody were in western blot and immunoprecipitation to study its interation with versican G3 domain in astrocytoma cell line U87 more
HIF-1 alpha
hypoxia inducible factor 1 subunit alpha
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
Vegfr-3
fms related receptor tyrosine kinase 4
total:15
Expression of VEGF-C and its receptor VEGFR-3 in the bone marrow of patients with acute myeloid leukaemia. 2008 to the paper
Santa Cruz anti-VEGFR-3 (sc-321) antibody was used to perform immunohistochemistry in order to study the expression of VEGF-C and VEGFR-3 in the acute myeloid leukaemia patients' bone marrow. more
NOX4
NADPH oxidase 4
total:2
Mutational analysis reveals distinct features of the Nox4-p22 phox complex. 2008 to the paper
Santa Cruz Biotechnology rabbit anti-Nox4 (7843) polyclonal antibody was used to perform western blot and immunocytochemistry in order to study the interaction of the key regulatory p22phox subunit with Nox4. more
PAR-1
coagulation factor II thrombin receptor
total:7
Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. 2007 to the paper
Santa Cruz Biotechnology PAR1 antibody was used in immunohistochemistry to determine the expression and functions of PARs in the gallbladder epithelium. more
thrombomodulin
total:8
IL-32-dependent effects of IL-1beta on endothelial cell functions. 2009 to the paper
R&Dsystems anti-human CD141/TM antibody was used in western blot to study the role for IL-32 in the effect of IL-1 on endothelial cell functions. more
PLAT
plasminogen activator, tissue type
total:2
Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. 2008 to the paper
Santa Cruz tPA antibody was used in western blot in order to demonstrate that lithium suppresses Smad3/4-dependent TGF-beta-responsive gene transactivation more
PROCR
protein C receptor
total:4
Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. 2007 to the paper
R&D systems goat antihuman EPCR antibody was used in immunohistochemistry to determine the major cell type (s) that EPCR is associated with and whether EPCR functions to mediate the effects of activated protein C (APC) on these cells. more
MCAM
melanoma cell adhesion molecule
total:4
Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-MelCAM antibody and mouse monoclonal anti-MelCAM antibody were used in human MCF-7 cells and paraffin sections from human tumor, and which were used in western blot and immunohistochemistry, to study the role for the effect of hypoxia on cross-talk between Syk and Lck in breast cancer progression and angiogenesis. more
CD105
endoglin
total:13
Extended flow cytometry characterization of normal bone marrow progenitor cells by simultaneous detection of aldehyde dehydrogenase and early hematopoietic antigens: implication for erythroid differentiation studies. 2008 to the paper
R&D Systems anti-105 antibody was used to perform flow cytometry in order to study the new characterization about the dissection of normal bone marrow progenitor cells more
PGF
placental growth factor
total:3
A reproducible and quantifiable model of choroidal neovascularization induced by VEGF A165 after subretinal adenoviral gene transfer in the rabbit. 2008 to the paper
Upstate mouse monoclonal anti-FGF/anti-FGF-2 antibody (clone bFM-2) was used in immunohistochemistry to determine the effects of the vascular endothelial growth factor (VEGF) A165 delivered using a high capacity adenoviral vector (HC Ad.VEGF-A) on vascular growth and pathological changes in the rabbit eye. more
ESM1
endothelial cell specific molecule 1
total:1
A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells. 2005 to the paper
Chemicon International anti-endothelial cell antibody P1H12 was used in human umbilical vein endothelial cells (HUVEC) and in flow cytometry to study the role for HEV-restricted sulfotransferase in rheumatoid arthritis and the interaction of it with lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells.
CRP
C-reactive protein
total:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 to the paper
Abcam monoclonal anti-C-reactive protein (CRP) antibody was used in immunohistochemistry to study the role for activated gp130 in inflammatory hepatocellular tumours. more
VEGF-C
vascular endothelial growth factor C
total:10
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Epitomics anti-VEGF antibody (1:1000) was used in western blot to study the effects of curcumin on the expression of peroxisome proliferator-activated receptor delta (PPARdelta) and related genes in HT-29 cells. more
TNF-alpha
tumor necrosis factor
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
IL-8
C-X-C motif chemokine ligand 8
total:46
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
R&D systems anti-IL8 antibody was used to perform immunocytochemistry in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
PAI-1
serpin family E member 1
total:16
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. 2010 to the paper
Novus Biologicals goat anti-human plasminogen antibody was used to perform ELISA in order to investigate the interaction between leptospiral endostatin-like protein A and human plasminogen. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
Akt
AKT serine/threonine kinase 1
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
CLDN5
claudin 5
total:3
Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. 2006 to the paper
Zymed Laboratories mouse anti-claudin-5 antibody was used in western blot and immunohistochemistry to demonstrate that CCL2 induces brain endothelial hyperpermeability via Rho/PKCalpha signal pathway interactions. more
ERK2
mitogen-activated protein kinase 1
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
neuropilin 1
total:7
Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts. 2007 to the paper
Santa Cruz Biotechnology NRP-1 antibody was used in western blot and immunohistochemistry to study the role of placenta growth factor in malignancy. more
ACVRL1
activin A receptor like type 1
total:4
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
R&D Systems goat anti-Acvrl1(AF370) antibody was used to perform immunohistochemistry and western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
ERK1
mitogen-activated protein kinase 3
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more