endosomes
gene
reagent
sample publication
sample review
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
Rab5
RAB5A, member RAS oncogene family
total:19
Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. 2009 to the paper
BD anti-Rab5 antibody was used in immunocytochemistry in order to investigate the mechanism of the autonomous cholesterol regulation activated by adenovirus membrane protein RID-alpha. more
PDCD6IP
programmed cell death 6 interacting protein
total:2
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. 2010 to the paper
Cell Signaling ALIX antibody was used to perform western blot in order to indicate an important role for the ubiquitin ligase activity of HOIP in CD40 signaling. more
NPC1
NPC intracellular cholesterol transporter 1
total:2
MiR-33 contributes to the regulation of cholesterol homeostasis. 2010 to the paper
Novus rabbit polyclonal anti-NPC1 antibody was used to carry out western blot analysis in order to investigate the role for intronic miRNA miR-33 in the regulation of cholesterol metabolism. more
Rab11
RAB11A, member RAS oncogene family
total:9
Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells. 2009 to the paper
Invitrogen rabbit polyclonal Rab11a antibody was used in western blot at 1:500 in order to investigate the function of Rab11 isoforms in regulating CFTR trafficking in T84 cells more
VPS35
VPS35 retromer complex component
total:1
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. 2007 to the paper
Dr. Juan S. Bonifacino (National Institute of Child Health and Human Development) Vps35 antibody was used in western blot and immunoprecipitation to study the functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors
RAB7A
RAB7A, member RAS oncogene family
total:5
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-Rab7 antibody was used to perform western blot in order to investigate the mechanism for the long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. more
RABGEF1
RAB guanine nucleotide exchange factor 1
total:2
Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. 2009 to the paper
BD Biosciences anti-Rabex-5 antibody was used to perform western blot in order to study the important role of the Rab22-CRabex-5-CRab5 in the endocytosis and degradation of epidermal growth factor. more
TSG101
tumor susceptibility 101
total:15
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Abcam monoclonal anti-Tsg101 was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
CHMP4A
charged multivesicular body protein 4A
total:2
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-CHMP4A was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
EGFR
epidermal growth factor receptor
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
EEA1
early endosome antigen 1
total:78
Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. 2012 to the paper
Millipore mouse anti-early endosome antigen1 was used to perform immunocytochemistry in order to show that ciliogenesis was regulated by an evolutionarily assembled cis-regulatory module more
STAM
signal transducing adaptor molecule
total:1
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. 2010 to the paper
ProteinTech Group STAM-1 polyclonal antibody was used to perform western blot and immunoprecipitation in order to clarify that the arrestin-2/STAM-1 complex modulates CXCR4 lysosomal sorting by ubiquitination of HRS.
RAB9A
RAB9A, member RAS oncogene family
total:5
Activation of cellular Arf GTPases by poliovirus protein 3CD correlates with virus replication. 2007 to the paper
Affinity Bioreagents anti-Rab9 antibody was used to perform western blot in order to study the interaction between Arf and Poliovirus Protein 3CD and its effect on poliovirus replication. more
EHD1
EH domain containing 1
total:1
A role for EHD4 in the regulation of early endosomal transport. 2008 to the paper
AnaSpec rabbit polyclonal anti-EHD1 antibody was used to carry out western blot analysis and immunoprecipitation assays in order to investigate the role for EHD4 in the control of trafficking at the early endosome.
VPS16
VPS16 core subunit of CORVET and HOPS complexes
UBC
ubiquitin C
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
transferrin receptor
total:70
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-CD71-APC antibody was used to perform flow cytometry in order to study the different trafficking mechanisms of endosomal Toll-like receptors mediated by UNC93B1. more
SNX1
sorting nexin 1
total:8
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells. 2007 to the paper
Proteintech SNX1 antibody was used in western blot in order to identify novel mitochondrial proteins affected by rotenone in dopaminergic cells. more
VAMP3
vesicle associated membrane protein 3
total:4
Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3.. 2010 to the paper
Synaptic Systems rabbit anti-VAMP3 antibody was used to carry out immunofluorescence assays in order to investigate the role for adaptor protein 3 in the regulation Toll-like receptor 9 signaling. more
VPS11
VPS11 core subunit of CORVET and HOPS complexes
EHD4
EH domain containing 4
total:1
A role for EHD4 in the regulation of early endosomal transport. 2008 to the paper
AnaSpec rabbit polyclonal anti-EHD4 antibody was used to carry out western blot analysis and immunoprecipitation assays in order to investigate the role for EHD4 in the control of trafficking at the early endosome.
VPS26A
VPS26, retromer complex component A
total:1
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. 2007 to the paper
Dr. Juan S. Bonifacino (National Institute of Child Health and Human Development) Vps29 antibody was used in western blot and immunoprecipitation to study the functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors
OCRL
OCRL inositol polyphosphate-5-phosphatase
DNAJC13
DnaJ heat shock protein family (Hsp40) member C13
AMSH
STAM binding protein
total:1
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. 2010 to the paper
ProteinTech Group AMSH polyclonal antibody was used to perform western blot in order to clarify that the arrestin-2/STAM-1 complex modulates CXCR4 lysosomal sorting by ubiquitination of HRS.
VPS33A
VPS33A core subunit of CORVET and HOPS complexes
syntaxin 6
total:7
The DnaJ-domain protein RME-8 functions in endosomal trafficking. 2005 to the paper
BD Transduction Laboratories mouse monoclonal antibody against syntaxin 6 was used in immunocytochemistry to study the function of a DnaJ domain-containing protein RME-8 in endosomal trafficking. more
CIN85
SH3 domain containing kinase binding protein 1
IST1
IST1 factor associated with ESCRT-III
total:1
Essential role of hIST1 in cytokinesis. 2009 to the paper
ProteinTech Group anti-alpha-IST1 antibody was used to perform western blot in order to show that the hIST1 play an important role in cytokinesis.
NHE5
solute carrier family 9 member A5
TLR3
toll like receptor 3
total:9
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 to the paper
Santa Cruz Biotechnology goat polyclonal anti-human TLR3 was used in immunohistochemistry to study the expression of toll-like receptors in verruca and molluscum contagiosum in cryostat sections from human skin. more
RAB4A
RAB4A, member RAS oncogene family
total:8
Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-Rab4 antibody was used to perform western blot in order to investigate the mechanism for the long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. more
STX16
syntaxin 16
total:1
Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. 2007 to the paper
Dr. W. Hong (IMCB, Singapore) polyclonal Syn16 antibody was used in immunocytochemistry to study the role of syntaxin 16 and syntaxin 5 in efficient retrograde transport of several exogenous and endogenous cargo proteins
VPS29
VPS29 retromer complex component
total:1
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. 2007 to the paper
Dr. Juan S. Bonifacino (National Institute of Child Health and Human Development) Vps29 antibody was used in western blot and immunoprecipitation to study the functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors
AP1AR
adaptor related protein complex 1 associated regulatory protein
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
total:1
Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells. 2009 to the paper
P. de Camilli anti-PI4KII alpha antibody was used for western blot to elucidated the interaction between Hermansky-Pudlak Syndrome protein complexes and phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.
CBL
Cbl proto-oncogene
total:13
Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. 2008 to the paper
Cell Signaling Technology anti-pY774-c-Cbl antibody was used to carry out western blot analysis in order to investigate the mechanism for Lyn kinase regulating imatinib sensitivity in chronic myelogenous leukemia cells. more
VPS4A
vacuolar protein sorting 4 homolog A
total:1
Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. 2005 to the paper
Bethyl Laboratory Inc. rabbit anti-SKD1 antibody was used in western blot to study the interaction of the mammalian endosomal sorting complex required for rransport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1
STX7
syntaxin 7
total:4
A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels. 2009 to the paper
Synaptic Systems rabbit polyclonal syntaxin 7 antibody was used in immunocytochemistry in order to investigate the role of SNARE complex containing VAMP7 and Vti1a in the regulation of a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells. more
MYO6
myosin VI
total:2
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. 2007 to the paper
Sigma mouse anti-myosin VI antibody was used to carry out western blot analysis in order to investigate the role for UNC-45 in the regulation of tumor cell proliferation and metastasis. more
VTI1B
vesicle transport through interaction with t-SNAREs 1B
total:1
Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. 2005 to the paper
Pharmingen monoclonal antibody for the golgi marker Vti1b was used in immunocytochemistry to study the effects of the inactivation of NPC1L1 on multiple lipid transport and diet-induced hypercholesterolemia
transferrin
total:17
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. 2009 to the paper
Stressgen anti-transferrin antibody was used for immunohistochemistry in order to demonstrate that in Parkinson's disease, a novel transferrin/TfR2-mediated mitochondrial iron transport system was disrupted more