endometriosis
gene
reagent
sample publication
sample review
HOXA10
homeobox A10
total:3
Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development. 2007 to the paper
Santa Cruz Biotechnology HOXA10 antibody was used in immunohistochemistry to study the role of Hoxa10 in normal uterine development. more
ARID1A
AT-rich interaction domain 1A
total:1
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. 2011 to the paper
Santa Cruz Biotechnology anti-ARID1a antibody was used to perform western blot in order to study the role of SWI/SNF in regulation of the latent HIV LTR before and after transcriptional activation.
progesterone receptor
total:38
The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. 2009 to the paper
Santa Cruz PR monoclonal antibody was used in immunohistochemistry in order to investigate the role of neurotensin receptor-1 pathway in the regulation of human ductal breast cancer progression. more
aromatase
cytochrome P450 family 19 subfamily A member 1
total:4
GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. 2008 to the paper
Santa Cruz Biotechnology goat anti-CYP19 (1:200) polyclonal antibody was used to perform immunohistochemistry in order to study the physiological functions of GPRC6A. more
SF-1
nuclear receptor subfamily 5 group A member 1
total:6
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. 2007 to the paper
Millipore anti-SF1 was used to perform immunoprecipitation in order to study the elements that bind to SF1. more
IL1R2
interleukin 1 receptor type 2
total:2
Stable inhibition of interleukin 1 receptor type II in Ishikawa cells augments secretion of matrix metalloproteinases: possible role in endometriosis pathophysiology. 2007 to the paper
R&D Systems polyclonal goat anti-human IL1R2 antibody was used in western blot and immunocytochemistry to evaluate the role of IL1R2 deficiency in endometriosis pathophysiology. more
WNT4
Wnt family member 4
total:2
Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. 2008 to the paper
Santa Cruz Biotechnology affinity-purified polyclonal Wnt-4 antibody was used in western blot in order to demonstrate that integration beta-catenin/Lef-1/Tcf-3 signaling with ERalpha is necessary for estrogen-dependent endogenous gene regulation in uterine biology more
PROK1
prokineticin 1
total:1
The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. 2006 to the paper
R&D Systems anti-EG-VEGF (prokineticins) antibody (no. MAB1209) was used in protein and paraffin sections from human prostate, and which were used in western blot and immunohistochemistry, to study the expression of EG-VEGF/PK1 and PK2 and their receptors (PK-R1 and PK-R2) in human prostate and their involvement in cancer.
ERbeta
estrogen receptor 2
total:24
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. 2009 to the paper
GeneTex mouse monoclonal anti-ER antibody (C14C8) was used in immunohistochemistry, immunocytochemistry, and immunoprecipitation to study the effect of estrogen receptormediated nuclear interaction between IRS-1 and Rad51 on homologous recombination directed DNA repair in medulloblastoma. more
VEGF
vascular endothelial growth factor A
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
ER
estrogen receptor 1
total:112
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Santa Cruz anti-ERa antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
TRPV1
transient receptor potential cation channel subfamily V member 1
total:4
Cellular localization of kinin B1 receptor in the spinal cord of streptozotocin-diabetic rats with a fluorescent [Nalpha-Bodipy]-des-Arg9-bradykinin. 2009 to the paper
Chemicon mouse anti-TRPV1 antibody was used for western blot in order to investigate the role of B1R in the regulation of oxidative stress. more
PTGS2
prostaglandin-endoperoxide synthase 2
total:54
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Santa Cruz Biotechnology anti-COX-2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more
follistatin
total:2
Follistatin-like protein-1 is a novel proinflammatory molecule. 2006 to the paper
R&D Systems FSTL-1 antibody was used in immunohistochemistry to demonstrate Follistatin-like protein-1 as a novel proinflammatory molecule. more
AMH
anti-Mullerian hormone
total:5
Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice. 2007 to the paper
Santa Cruz Biotechnology AMH antibody (1:200) was used in immunohistochemistry to study the role of Fog2 and Gata4 transcription factors in fetal testis development in mice. more
MMP-2
matrix metallopeptidase 2
total:37
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion. 2009 to the paper
Santa Cruz monoclonal MMP-2 antibodies were used in western blot in order to investigate the role of matrix metalloproteinase-2 (MMP-2) gene in invasiveness and adhesion of human pancreatic cancer cell line, BxPC-3. more
RANTES
C-C motif chemokine ligand 5
total:14
Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice. 2009 to the paper
Chemicon anti-alpha5 antibody was used to incubate the human CD34+ cells for 30 minutes at 4- in order to investigate the role of beta4 integrin, alpha5 integrin, and CXCR4 in cytokine-treated human cord blood CD34+ cells. more
PTGER2
prostaglandin E receptor 2
total:4
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Cayman Chemicals anti-EP2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more
CFL1
cofilin 1
total:8
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Sigma-Aldrich polyclonal anti-cofilin and anti-phospho-cofilin antibody was used in western blot to identify Pak4 as a novel Gab1-interacting protein downstream from the Met receptor and to study its function. more
CA125
mucin 16, cell surface associated
total:6
Identification and characterization of ovarian cancer-initiating cells from primary human tumors. 2008 to the paper
Santa Cruz Biotechnology monoclonal anti-cancer antigen-125 (CA-125) antibody was used in immunocytochemistry to identify and characterize a self-renewing subpopulation of human ovarian tumor cells. more
INHBA
inhibin subunit beta A
total:9
Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. 2008 to the paper
Serotec anti-human INHBA was used to perform immunohistochemistry in dilution 1:300 in order to show that differentially overexpressed genes in gastric cancer are revealed by combining large-scale gene expression profiling and network analysis. more
IL-8
C-X-C motif chemokine ligand 8
total:46
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
R&D systems anti-IL8 antibody was used to perform immunocytochemistry in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
MCP-1
C-C motif chemokine ligand 2
total:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 to the paper
Santa Cruz anti-MCP-1 antibody was used to perform immunohistochemistry in order to study the effect of MCP1 and CD40 ligation on VEGF production. more
TIMP-2
TIMP metallopeptidase inhibitor 2
total:12
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism. 2008 to the paper
Chemicon International mouse anti-human TIMP-2 antibody was used to perform western blot in order to investigate the role of MT1-MMP-TIMP-2 interaction in controlling cell functions. more
NGF
nerve growth factor
total:2
NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. 2008 to the paper
Novus monoclone anti-NGF antibody (30 ug/ml) was used in cell culture in order to study the role of NGF or BDNF signaling in neuronal apoptotic death more
IL1R1
interleukin 1 receptor type 1
total:5
Control of chemokine gradients by the retinal pigment epithelium. 2008 to the paper
Abcam IL-1R1 antibody was used in western blot in order to examine the physiological responses of human fetal retinal pigment epithelia (hfRPE) after polarized activation of proinflammatory cytokine receptors in vitro more
EP4
prostaglandin E receptor 4
total:9
CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. 2008 to the paper
Abcam murine monoclonal anti-PTGER4 antibody was used to perform flow cytometric analysis in order to study the important role of CD30 signaling in Hodgkin's and anaplastic large cell lymphoma (ALCL) cell lines. more
trkA
neurotrophic receptor tyrosine kinase 1
total:27
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Upstate anti-TrkA antibody (06-574, 1:100) was used to perform immunostaining in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
FOXP3
forkhead box P3
total:17
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
eBioscience Alexa 647 anti-FoxP3 monoclonal antibody was used to perform flow cytometry to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
MIF
macrophage migration inhibitory factor
total:9
A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. 2010 to the paper
Santa Cruz rabbit anti-MIF antibody was used to perform western blotting and immunoprecipitation in order to determine the role of NRAGE in regulating NF-kappaB activity. more
CLDN4
claudin 4
total:6
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. 2005 to the paper
Zymed Laboratories mouse anti-claudin-4 monoclonal antibody was used in western blot and immunoprecipitation to study that phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction carrier function in ovarian cancer cells. more
PTPN22
protein tyrosine phosphatase non-receptor type 22
p75NTR
nerve growth factor receptor
total:17
Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line. 2008 to the paper
Novus Biologicals anti-p75NTR antibody was used to perform immunocytochemistry in order to show that cellular phenotype can be changed after exposure to acid and bile salt in Barrett's epithelial cell line. more
IL-6
interleukin 6
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
TNF-alpha
tumor necrosis factor
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
PEDF
serpin family F member 1
total:7
Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis. 2010 to the paper
Santa Cruz anti-PEDF antibody was used in western blot to investigate the role of lentivirus-mediated gene transfer of PEDF in the regulation of the growth of ocular melanoma and its hepatic micrometastasis. more
p50
nuclear factor kappa B subunit 1
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
Akt
AKT serine/threonine kinase 1
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
FGFR2
fibroblast growth factor receptor 2
total:9
Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. 2008 to the paper
Santa Cruz rabbit polyclonal anti-FGFR2 was used to perform western blot in order to show that VHL tumor supppressor gene has endothelial function through fibroblast growth factor receptor signaling. more
IL-10
interleukin 10
total:23
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
R&D Systems anti-IL-10 antibody was used to perform ELISA in order to study how gut microbiota regulate immunesystem. more
ICAM-1
intercellular adhesion molecule 1
total:30
Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy. 2011 to the paper
R&D systems anti-ICAM-1 antibody was used to perform immunocytochemistry in order to study the remodelling of cortical actin at natural killer cell immune synapses. more
p53
tumor protein p53
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
leptin
total:6
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Ob antibody was used to carry out western blot analysis in order to identify the binding sites of PPAR Gramma and RXR in a genome wide manner during adipogenesis. more
MMP-1
matrix metallopeptidase 1
total:13
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 to the paper
Calbiochem anti-MMP-1 monoclonal antibody was used to perform western blot in order to study the role of CD147 promoted myofibroblast differentiation in tissue remodeling. more
p110
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
MMP-9
matrix metallopeptidase 9
total:45
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 to the paper
Epitomics anti-MMP-9 antibody was used in immunohistochemistry to study the mechanism of protein kinase D1 for inhibiting breast tumour cell invasion. more
ERK1
mitogen-activated protein kinase 3
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more
TIMP-1
TIMP metallopeptidase inhibitor 1
total:16
Matrix metalloproteinase activity in pediatric acute lung injury. 2009 to the paper
R/D Systems TIMP-1 antibody was used to perform immunoblots in order to study the role of matrix metalloproteinase in pediatric acute lung injury. more
Flt-1
fms related receptor tyrosine kinase 1
total:16
The association of vascular endothelial growth factor receptor-1 with the risk of cancer progression following radical prostatectomy. 2008 to the paper
R&D Systems goat anti-human VEGFR-1 polyclonal antibody (catalog number: AF321) was used to perform immunochemistry assays in order to demonstrate that VEGFR-1 expression is not related to the risk of cancer progression following radical prostatectomy. more
MMP-3
matrix metallopeptidase 3
total:8
Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. 2010 to the paper
Santa Cruze Biotechnology anti-human MMP-3 polyclonal antibody was used for western blot in order to investigate the role of PGE2 on matrix metalloproteinase synthesis in chondrocytes. more
p27
cyclin dependent kinase inhibitor 1B
total:118
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. 2012 to the paper
BD Pharmingen anti-p27CDKN1B antibody was used to perform western blot in order to show that p53-dependent cell proliferation and survival could be regulated by atg7. more
IL-18
interleukin 18
total:7
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. 2005 to the paper
BioSource Europe SA anti-IL-18 antibody (which was in ELISA kit) was used in venous blood samples from human and in ELISA to study the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. more
survivin
baculoviral IAP repeat containing 5
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
IFN-gamma
interferon gamma
total:62
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 to the paper
R&D Systems anti-IFN-gamma was used in 5ug/ml to perform cell stimulation in order to show that blood-brain barrier integrity and CNS immune quiescence were promoted by sonic hedgehog pathway. more
IL-1beta
interleukin 1 beta
total:30
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-1-beta mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
osteopontin
secreted phosphoprotein 1
total:12
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Calbiochem anti-osteopontin antibody (1:100) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
ERK2
mitogen-activated protein kinase 1
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
Ras
KRAS proto-oncogene, GTPase
total:20
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Oncogene Ras antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
GSTM1
glutathione S-transferase mu 1
total:2
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients. 2008 to the paper
Lab Vision Corporation anti-GSTM antibody was used to perform immunocytochemistry in order to show that the expression of glutathione S-transferase pi is at a higher level in the brains of medically intractable epileptic patients. more
E-cadherin
cadherin 1
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
TLR4
toll like receptor 4
total:37
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. 2010 to the paper
R&D mouse monoclonal anti-TLR4 antibody was used to perform western blot in order to study the immune defence role of TLR4 and HD5 in primary endocervical epithelial cells. more
PAI-1
serpin family E member 1
total:16
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. 2010 to the paper
Novus Biologicals goat anti-human plasminogen antibody was used to perform ELISA in order to investigate the interaction between leptospiral endostatin-like protein A and human plasminogen. more
TGF-beta1
transforming growth factor beta 1
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
PTEN
phosphatase and tensin homolog
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more