diabetes mellitus
gene
reagent
sample publication
sample review
SLC47A1
solute carrier family 47 member 1
total:1
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Invitrogen anti-DAPI antibody was used to perform immunohistochemistry in order to study synaptic plasticity.
SLC19A2
solute carrier family 19 member 2
total:2
TRE-dependent transcription activation by JDP2-CHOP10 association. 2008 to the paper
Santa Cruz THTR1 polyclonal antibody was used in ChIP assays in order to identify CHOP10 as a novel protein associating protein for JDP2 more
HBA1
hemoglobin subunit alpha 1
total:2
Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. 2008 to the paper
Novus Biologicals anti-hemoglobin alpha1 antibody was used in western blot to identify novel host molecules in the brain that are affected in the course of the pathological manifestation of CM. more
insulin
total:25
Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. 2012 to the paper
Alpco insulin ELISA kit was used to perform ELISA in order to investigate the regulatory effect of iron oxide nanoparticles on blood glucose in mice. more
DCAF17
DDB1 and CUL4 associated factor 17
HNF1A
HNF1 homeobox A
total:10
Inherent sexually dimorphic expression of hepatic CYP2C12 correlated with repressed activation of growth hormone-regulated signal transduction in male rats. 2008 to the paper
Santa Cruz Biotechnology HNF-4alpha antibdoy was used in western blot in order to demonstrate that continuous GH induces CYP2C12 expression by activating Erk1 and Erk2 via the GHR more
AGER
advanced glycosylation end-product specific receptor
TCF7L2
transcription factor 7 like 2
total:6
Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. 2008 to the paper
Upstate Biotechnology anti-TCF-4 antibody was used in immunoprecipitation and western blotting to investigate the action mechanism of the growth inhibition induced by bis[2-(acylamino)phenyl] disulfide. more
GLUT4
solute carrier family 2 member 4
total:11
ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. 2009 to the paper
Millipore anti-Glut4 antibody was used to carry out western blot analysis in order to investigate the regulation of adipocyte glucose transport by ClipR-59 mediated Akt cellular compartmentalization. more
CDKAL1
CDK5 regulatory subunit associated protein 1 like 1
WFS1
wolframin ER transmembrane glycoprotein
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
total:1
MiR-33 contributes to the regulation of cholesterol homeostasis. 2010 to the paper
Santa Cruz Biotechnology polyclonal anti-HMGCR antibody was used to carry out western blot analysis in order to investigate the role for intronic miRNA miR-33 in the regulation of cholesterol metabolism.
TXNIP
thioredoxin interacting protein
total:2
Protective effects of a compound herbal extract (Tong Xin Luo) on free fatty acid induced endothelial injury: implications of antioxidant system. 2008 to the paper
Cell Signaling anti-thioredoxin interacting protein (Txnip) antibody was used in western blot to study the protective role of a compound herbal extract (Tong Xin Luo) on free fatty acid induced endothelial injury. more
PPARgamma
peroxisome proliferator activated receptor gamma
total:28
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-PPAR gamma antibody was used to carry out western blot analysis and Ch-IP assays in order to identify the binding sites of PPAR Gramma and RXR in a genome wide manner during adipogenesis. more
glucokinase
total:1
Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm. 2008 to the paper
ABGENT anti-GCK(N-term) polyclonal antibody was used to perform immunoblotting in order to study the role of spermatogenic cell-specific type 1 hexokinase(HK1S) in sperm.
CRP
C-reactive protein
total:13
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. 2009 to the paper
Abcam monoclonal anti-C-reactive protein (CRP) antibody was used in immunohistochemistry to study the role for activated gp130 in inflammatory hepatocellular tumours. more
FTO
FTO alpha-ketoglutarate dependent dioxygenase
PDX-1
pancreatic and duodenal homeobox 1
total:8
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. 2008 to the paper
Santa Cruz Pdx1 antibody was used in western blot in order to study the role of Gsk-3beta in control of beta-cell mass in insulin-resistant diabetic models more
adiponectin
adiponectin, C1Q and collagen domain containing
total:6
The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. 2009 to the paper
Calbiochem rabbit polyclonal antibody against adiponectin was used in western blot and immunoprecipitation to investigate the role of DLK in the regulation of 3T3-L1 adipocyte differentiation. more
insulin receptor
total:22
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. 2009 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti subunit of insulin receptors (IR) antibody was used in western blot and immunocytochemistry to test the hypothesis that insulin signaling provides a physiological defense mechanism against the synaptotoxicity of Abeta-derived diffusible ligands. more
GPX1
glutathione peroxidase 1
total:3
The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. 2009 to the paper
Affinity BioReagents ATP synthase antibody was used for western blot in order to investigate the role of mitochondria in endothelial cell dysfunction. more
AGT
angiotensinogen
total:6
Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy. 2008 to the paper
IgG corporation rabbit polyclonal anti-ang II serum was used in immunohistochemistry in order to study the glomerular AGT's expression and its correlation with expression of other RAS components more
eNOS
nitric oxide synthase 3
total:36
Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. 2009 to the paper
Upstate Laboratories anti-eNOS antibody was used for western blot in order to investigate the role of purinergic in the regulation of endothelial nitric oxide synthase activity in endothelial cells. more
glucagon
total:13
Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. 2009 to the paper
Sigma anti-glucagon antibody was used to perform immunohistochemistry in order to study the role of mitochondrial flavoprotein apoptosis inducing factor. more
renin
total:2
Expression of components of the renin-angiotensin system in autosomal recessive polycystic kidney disease. 2005 to the paper
Dr. Tadashi Inagami renin antibody was used in immunohistochemistry to study the expression of components of the renin-angiotensin system in autosomal recessive polycystic kidney disease. more
CDKN2B
cyclin dependent kinase inhibitor 2B
total:1
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 to the paper
Santa Cruz anti-p15 was used to perform western blot in order to show the role of cyclin K and cyclin D1b in multiple myeloma.
AHSG
alpha 2-HS glycoprotein
total:1
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe. 2010 to the paper
R&D systems anti-fetuin A antibody was used to perform western blot in order to study the role of non-directed activity-based protein profiling plays in the identification of enzymes that are either predominantly or exclusively labeled in living cells.
MYH9
myosin heavy chain 9
total:3
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. 2009 to the paper
Sigma anti-NMHC-IIA antibody was used to perform western blot in order to study the assemble of mammalian nonmuscle myosin II in live cells. more
haptoglobin
total:7
Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. 2008 to the paper
Sigma-Aldrich polyclonal rabbit anti-haptoglobin antibody (1:20,000) was used for western blot in order to investigate the distinct roles of apolipoprotein components in a transgenic mouse model. more
leptin
total:6
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Ob antibody was used to carry out western blot analysis in order to identify the binding sites of PPAR Gramma and RXR in a genome wide manner during adipogenesis. more
erythropoietin
total:7
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
R&D Systems anti-Epo antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
PPARGC1A
PPARG coactivator 1 alpha
total:6
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure. 2009 to the paper
Santa Cruz Biotechnology anti-PGC-1-alpha rabbit polyclonal antibody was used to carry out immunohistochemistry assays in order to investigate the functional role of Myc in mediating hypertrophic cardiomyopathy and heart failure. more
visfatin
nicotinamide phosphoribosyltransferase
total:1
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. 2010 to the paper
Bethyl Laboratories NAMPT antibody was used for western blot in order to investigate the role of DBC1 in the regulation of SIRT1 activity and high-fat diet induced liver steatosis in mice.
apolipoprotein B
total:14
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 to the paper
Abcam anti-ApoB100 antibody was used in western blot to study the formation requirement of efficient hepatitis C virus particle. more
PPAR
peroxisome proliferator activated receptor alpha
total:9
Integration of microRNA miR-122 in hepatic circadian gene expression. 2009 to the paper
Abcam rabbit polyclonal antibody PPAR was used for immunoprecipitation in order to study the circadian gene expression of integration of microRNA miR-122 in hepatic. more
AGTR1
angiotensin II receptor type 1
total:9
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. 2009 to the paper
Santa Cruz rabbit anti-AT1 was used to perform immunohistochemistry in order to show that the expression of ETB and AT1 receptor is upregulated in ischemic heart disease patients. more
IGF-1
insulin like growth factor 1
total:13
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
Abcam rabbit anti-IGF-1 antibody was used in western blot to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
CD40 ligand
total:13
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 to the paper
Santa Cruz anti-CD40L antibody (1:200) was used to perform immunohistochemistry in order to study the effect of MCP1 and CD40 ligation on VEGF production. more
VEGF
vascular endothelial growth factor A
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
total:1
Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma. 2007 to the paper
Novocastra Laboratories anti-HLA Class II (DR) was used to perform immunohistochemistry in order to show CD80 and CD86 may be potential nasopharyngeal carcinoma markers for clinical outcome.
von Willebrand factor
total:32
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. 2009 to the paper
Serotec sheep anti-VWF was used to test von Willebrand factor (VWF) in order to research Rab27a and MyRIP's regulation to the amount and multimeric state of VWF released from endothelial cells. more
glucocorticoid receptor
nuclear receptor subfamily 3 group C member 1
total:20
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. 2009 to the paper
BD rat monoclonal antibodies against mouse Gr-l were used in flow immunocytometry to investigate the role of the migrant cDCs in the regulation of CD11c, MHC II, and CD86. more
ApoE
apolipoprotein E
total:19
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 to the paper
Calbiochem anti-ApoE antibody was used in western blot to study the formation requirement of efficient hepatitis C virus particle. more
TNF-alpha
tumor necrosis factor
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
ACE
angiotensin I converting enzyme
total:8
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Santa Cruz anti-ACE was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
MCP-1
C-C motif chemokine ligand 2
total:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 to the paper
Santa Cruz anti-MCP-1 antibody was used to perform immunohistochemistry in order to study the effect of MCP1 and CD40 ligation on VEGF production. more
leptin receptor
total:9
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. 2007 to the paper
Santa Cruz Biotechnology OB-R antibodies (C-20: specific for long form of leptin receptor, H-300: for both long and short form of leptin receptor, mouse monoclonal B-3: for both long and short forms of leptin receptor) were used in immunoprecipitation (C-20 and H-300) and western blot (B-3) to study the recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3 by leptin and its stimulation of breast cancer cells. more
IL-6
interleukin 6
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more