cytoplasm
gene
reagent
sample publication
sample review
HuR
ELAV like RNA binding protein 1
total:14
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43. 2010 to the paper
Santa Cruz Biotechnology mouse monoclonal anti-HuR antibody(3A2, 1:1000) was used to perform immunoblotting in order to characterize the TAR DNA-binding Protein-43's alternative isoforms inclusion body. more
NPM1
nucleophosmin 1
total:11
Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. 2010 to the paper
Zymed anti-NPM antibody was used for western blot in order to investigate the role for activated Bax in the regulation of p53-dependent, transcription-independent neural precursor cell apoptosis. more
survivin
baculoviral IAP repeat containing 5
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
XPO1
exportin 1
total:7
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. 2009 to the paper
Santa Cruz Biotechnology CRM-1 antibody was used for Western blotting in order to investigate the effect of LKB1 on nucleocytoplasmic transport. more
maspin
serpin family B member 5
total:8
Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts. 2008 to the paper
Oncogene Research Products rabbit polyclonal anti-human maspin antibody was used in immunocytochemistry to determine whether DNA methylation of the maspin promoter and histone H3 dimethylation are involved in the mechanism of down regulation of maspin synthesis in human corneal stromal fibroblasts and myofibroblasts. more
TDP 43
TAR DNA binding protein
total:37
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. 2010 to the paper
ABCAM anti-human TARDBP antibody(ab57105, 1.25 mg/ml) was used to perform western blot in order to introduce a new recombinase-mediated cassette exchange system that allows targeted insertion and conditional expression of any given genes. more
FUS
FUS RNA binding protein
total:6
A yeast model of FUS/TLS-dependent cytotoxicity. 2011 to the paper
Abcam anti-FUS antibody (1:1000) was used to perform western blot in order to study the FUS/TLS-dependent cytotoxicity in yeast. more
p27
cyclin dependent kinase inhibitor 1B
total:118
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. 2012 to the paper
BD Pharmingen anti-p27CDKN1B antibody was used to perform western blot in order to show that p53-dependent cell proliferation and survival could be regulated by atg7. more
p53
tumor protein p53
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
PABPC4
poly(A) binding protein cytoplasmic 4
IGF2BP3
insulin like growth factor 2 mRNA binding protein 3
PAFAH1B1
platelet activating factor acetylhydrolase 1b regulatory subunit 1
total:6
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. 2010 to the paper
Sigma anti-LIS1 antibody was uesd to perform western blot in order to study the regulation of the LIS1/dynein pathway by NudC-like protein 2 via stabilizing LIS1 with Hsp90. more
beta-catenin
catenin beta 1
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
DACT1
dishevelled binding antagonist of beta catenin 1
14 3 3 protein epsilon
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
total:5
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Santa Cruz Biotechnology anti-14-3-3epsilon antibody (1:2000) was used in western blot to study the effects of curcumin on the expression of peroxisome proliferator-activated receptor delta (PPARdelta) and related genes in HT-29 cells. more
ERbeta
estrogen receptor 2
total:24
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. 2009 to the paper
GeneTex mouse monoclonal anti-ER antibody (C14C8) was used in immunohistochemistry, immunocytochemistry, and immunoprecipitation to study the effect of estrogen receptormediated nuclear interaction between IRS-1 and Rad51 on homologous recombination directed DNA repair in medulloblastoma. more
E-cadherin
cadherin 1
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
FKHR
forkhead box O1
total:20
Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes. 2009 to the paper
Santa Cruz anti-FKHR antibody was used to perform ChIP assays in order to study the roles of PXR in the regulations of CYP4F12 and the coactivation and corepression to a broad range of promoters. more
AP1M1
adaptor related protein complex 1 subunit mu 1
PABPC1
poly(A) binding protein cytoplasmic 1
total:7
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43. 2010 to the paper
Santa Cruz Biotechnology mouse monoclonal anti-PABP antibody(10E10, 1:200) was used to perform immunofluorescence in order to characterize the TAR DNA-binding Protein-43's alternative isoforms inclusion body. more
PRMT1
protein arginine methyltransferase 1
total:2
Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis. 2009 to the paper
Upstate anti-PRMT1 antibody was used to perform western blot in order to study the functions of protein arginine methyltransferase 1. more
CDK2
cyclin dependent kinase 2
total:53
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Cdk2 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
androgen receptor
total:52
Overcoming mutation-based resistance to antiandrogens with rational drug design. 2013 to the paper
Upstate anti-AR (PG-21) antibody was used to perform ChIP in order to study the rational drug design for castration-resistant prostate cancer without mutation-based resistance to antiandrogens. more
UBC
ubiquitin C
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
hnRNP C1/C2
heterogeneous nuclear ribonucleoprotein C
total:10
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. 2013 to the paper
Abcam anti-hnRNP-C1/C2 antibody was used to perform western blot to investigate the role of nonsense mediated decay exons in the control of synaptic protein levels after seizure. more
Akt
AKT serine/threonine kinase 1
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
nucleolin
total:22
A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. 2010 to the paper
Zymed mouse anti-Nucleolin was used to perform immunocytochemistry in order to study the relation between Drosophila p53 and the human p53 network. more
YAP1
Yes1 associated transcriptional regulator
total:3
Hippo pathway effector Yap is an ovarian cancer oncogene. 2010 to the paper
Santa Cruz Biotechnology anti-Yap antibody was used in western blot and immunohistochemistry to study the effect of the hippo pathway effector Yap on the progression of ovarian cancer. more
AXIN1
axin 1
total:2
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. 2009 to the paper
Zymed anti-axin antibody was used in western blot in order to show that Wnt/catenin signaling, osteoblast function, and bone formation can be negatively regulated by the N-cadherin-axin-LRP5 interaction. more
CSE1L
chromosome segregation 1 like
total:1
CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells. 2008 to the paper
BD Pharmingen Transduction Laboratories mouse monoclonal anti-CAS antibody (clone 24) was used in western blot and immunocytochemistry to study the different effect of CSE1L/CAS on invasion, metastasis, and proliferation of cancer cells.
stratifin
total:6
Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry. 2008 to the paper
Santa Cruz Biotechnology anti-stratifin antibody was used in immunohistochemistry and western blot to discover head-and-neck cancer biomarkers. more
ICAT
catenin beta interacting protein 1
total:12
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. 2013 to the paper
Millipore anti-active-beta-catenin antibody was used to perform immunohistochemistry to study the role of Gcm1 and Fzd5 in regulating trophoblast differentiation and sites of chorionic branching morphogenesis. more
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
total:6
Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis. 2008 to the paper
Sigma monoclonal anti-hnRNP-A1 antibody was used to perform immunoprecipitation in order to study the relevant role of RNA binding proteins(RBPs) in posttranscriptional regulation of CML development and progression. more
14 3 3 protein tau
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
total:21
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. 2011 to the paper
Santa Cruz Biotechnology anti-14-3-3 antibody was used to perform western blot in order to study the role of SWI/SNF in regulation of the latent HIV LTR before and after transcriptional activation. more
NME1
NME/NM23 nucleoside diphosphate kinase 1
total:8
Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 2010 to the paper
Abcam rabbit anti-nm23 antibody was used to carry out western blot analysis in order to clarify an alternative glycolytic pathway in many rapidly proliferating cells. more
IKK alpha
component of inhibitor of nuclear factor kappa B kinase complex
total:49
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. 2011 to the paper
Santa Cruz Biotechnology anti-IKKalpha monoclonal antibody was used to perform western blot in order to study that cleveage of NIK leads to noncanonical NF- kB activation more
S100A6
S100 calcium binding protein A6
total:4
Up-regulation, modification, and translocation of S100A6 induced by exposure to ionizing radiation revealed by proteomics profiling. 2007 to the paper
Sigma-Aldrich S100A6 antibody was used in western blot to report an increase in S100A6 protein level in colon and lung cancer cells postexposure to ionizing radiation. more
Skp2
S-phase kinase associated protein 2
total:17
Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy. 2009 to the paper
Zymed anti-Skp2 was used in 1:1000 dilution to perform western blot in order to show that CSN plays an important role for cell autophagy in K562 cells. more
PTK6
protein tyrosine kinase 6
total:3
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. 2005 to the paper
Santa Cruz Biotechnology anti-BRK polyclonal antibody was used in western blot to study that tyrosine phosphorylation of Sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. more
CPEB1
cytoplasmic polyadenylation element binding protein 1
total:2
Analysis of the 3' untranslated regions of alpha-tubulin and S-crystallin mRNA and the identification of CPEB in dark- and light-adapted octopus retinas.. 2008 to the paper
Affinity CPEB antibody was used in western blot at 1:5,000 dilution in order to investigate the presence of CPEs in alpha-tubulin and S-crystallin mRNA more
eIF4E
eukaryotic translation initiation factor 4E
total:37
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. 2013 to the paper
BD BioSciences anti-eIF4E antibody was used to perform western blot in order to check the protein levels when hnRNP-Q was knocked down. more
NUDEL
nudE neurodevelopment protein 1 like 1
total:1
Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport.. 2009 to the paper
Sigma-Aldrich anit-VSVG antibody was used to perform immunocytochemistry to study the role of cPLA2a in the formation of intercisternal tubular continuities and transport through the Golgi complex.
CELF1
CUGBP Elav-like family member 1
total:3
SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. 2009 to the paper
Santa Cruz Biotechnology mouse monoclonal anti-CUG-BP1 antibody was used in western blot to study the roles for SRp20 and CUG-BP1 in modulating insulin receptor exon 11 alternative splicing. more
mTOR
mechanistic target of rapamycin kinase
total:33
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Santa Cruz polyclonal anti-mTOR (N-19 (alpha-FRAP) was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
EGFR
epidermal growth factor receptor
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
p16
cyclin dependent kinase inhibitor 2A
total:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-p19 antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
HNRNPK
heterogeneous nuclear ribonucleoprotein K
total:6
Proteomic and genomic analysis of PITX2 interacting and regulating networks. 2009 to the paper
Epitomics anti-hnRNP K antibody was used to perform western blot in order to find out the PITX2 interacting and regulating networks. more
SLC4A4
solute carrier family 4 member 4
total:1
Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities. 2005 to the paper
Chemicon rabbit anti-NBC1 antibody that recognizes the C-terminal region (amino acids 928 to 1035) of kNBC1 was used in western blot to study NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities.
p300
E1A binding protein p300
total:52
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Santa Cruz anti-p300 was used to perform western blot and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
ALYREF
Aly/REF export factor
total:2
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. 2010 to the paper
Santa Cruz monoclonal antibodies against Aly/THOC4 were used in western blot to investigate the role of THOC5/Fms in the maintenance of hematopoiesis and the regulation of THOC1. more
BRCA1
BRCA1 DNA repair associated
total:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Calbiochem anti-BRCA1 monoclonal antibody was used to perform immunoprecipitation in order to study the function of apicobasal polarity and regulation of stem cell in breast cancer more
p50
nuclear factor kappa B subunit 1
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
glyceraldehyde 3 phosphate dehydrogenase
glyceraldehyde-3-phosphate dehydrogenase
total:84
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Abcam anti-GAPDH antibody was used to perform western blot in order to study synaptic plasticity more
CDC25B
cell division cycle 25B
total:1
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. 2005 to the paper
BD Biosciences mouse anti-Cdc25B antibody was used in western blot to study the function of forkhead box M1 to regulate the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.
LAMC2
laminin subunit gamma 2
total:6
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 to the paper
Millipore anti-laminin gamma 2 chain antibody was used to perform immunohistochemistry in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas. more
Ran
RAN, member RAS oncogene family
total:17
A role for PVRL4-driven cell-cell interactions in tumorigenesis. 2013 to the paper
BD Biosciences mouse anti-RAN antibody was used to perform western blot in order to investigate the role of PVRL4 in tumor progression. more
p65
RELA proto-oncogene, NF-kB subunit
total:146
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Santa Cruz anti-p65 antibody was used to perform immunofluorescence in order to study the role of DNA-dependent protein kinase in the IRF-3-dependent innate immunity. more
14 3 3 protein beta alpha
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
total:9
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. 2008 to the paper
Santa Cruz 14-3-3beta antibody was used in western blot at dilution of 1/1000 in order to identify 14-3-3 beta and zeta isoforms and proteolytic fragments of alpha-spectrin as proteins released from degenerating neurons more
MRP2
ATP binding cassette subfamily C member 2
total:7
ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal ABCC2 antibody (H-300) and goat polyclonal ABCC2 antibody (H-17) were used in immunocytochemistry (1:400) to study its localization in the nuclear membrane of ovarian carcinomas and its correlation with resistance to cisplatin and clinical outcome. more
Smad4
SMAD family member 4
total:21
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
Santa Cruz rabbit anti-Smad4(H-552; 1:1,000) antibody was used to perform western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
YB 1
Y-box binding protein 1
total:6
Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. 2013 to the paper
Abcam anti-YB-1 antibody was used to perform western blotting in order to determine the subcellular distribution of the hnRNP-Q. more
La
small RNA binding exonuclease protection factor La
EPCAM
epithelial cell adhesion molecule
total:11
Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. 2010 to the paper
BD Biosciences anti-EpCam antibody was used to perform purification of primary lung tumor cells in order to study whether TLR7 and TLR8 expressed by human lung cancer cells induced cell survival and chemoresistance. more