crohn disease
gene
reagent
sample publication
sample review
total:2
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. 2006 to the paper
Cayman Chemical NOD2-specific rabbit antiserum was used in immunoprecipitation and western blot to measure its expression in primary keratinocytes and transfected HEK293 cells. more
total:3
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems PE-labeled anti-IL-23R mAb was used to perform flow cytometry in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
total:2
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. 2010 to the paper
R&D Systems anti-PTPN2 antibody was used for western blot in order to investigate the roles of MDA5 and PTPN2 in the regulation of pancreatic cell responses to the viral by-product double-stranded RNA. more
total:1
Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. 2009 to the paper
Developmental Studies Hybridoma Bank mouse anti-Dlg antibody (1:100) was used in immunocytochemistry in order to investigate the role of Sds22 in the regulation of epithelial cell polarity and shape.
total:1
Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. 2008 to the paper
Chemicon mouse mAb against Bassoon (1:250) was used in immunohistochemistry in order to demonstrate that apoE4 domain interaction is a contributor to apoE4-associated synaptic degeneration and functional synaptic deficits
total:3
MEKK4 is an effector of the embryonic TRAF4 for JNK activation. 2005 to the paper
Sigma anti-MEKK4 antibody was used in western blot and immunoprecipitation to study the association between TRAF4 and MEKK4 more
total:2
A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis. 2006 to the paper
Serotec neutrophils antibody was used in immunohistochemistry to determine the effects of A3AR modulation on mortality and hepatic and renal dysfunction in a murine model of sepsis. more
total:1
Daughter centriole elongation is controlled by proteolysis. 2010 to the paper
Proteintech Group rabbit anti-human FGFR1OP antibody was used to perform immunocytochemistry in order to study the role of proteolysis in daughter centriole elongation.
total:2
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. 2010 to the paper
Cell Signaling Mst1 antibody was used in western blot to investigate the role of hippo signaling in the regulation of mammalian organ size. more
total:4
Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target. 2006 to the paper
Santa Cruz Traf4 antibody was used in western blot to identify Traf4 interacting proteins. more
total:1
Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation. 2008 to the paper
Abgent anti-TPMT was used to perform western blot in order to show that autophagy is one of the mechanisms responsible for allozyme thiopurine S-methyltransferase (TPMT) *3A degradation.
total:1
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. 2005 to the paper
Genemed anti-myosin IXb antibody made against the C-terminal peptide CSASTESLLEERAVRGAAEE was used in western blot to study the role of BIG1 as a binding partner of myosin IXb to regulate its Rho-GTPase activating protein activity.
total:9
CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. 2008 to the paper
Abcam murine monoclonal anti-PTGER4 antibody was used to perform flow cytometric analysis in order to study the important role of CD30 signaling in Hodgkin's and anaplastic large cell lymphoma (ALCL) cell lines. more
total:1
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. 2010 to the paper
ADL rabbit anti-HD5 antibody was used to perform western blot in order to study the immune defence role of TLR4 and HD5 in primary endocervical epithelial cells.
total:37
Role of Toll-like receptor 4 and human defensin 5 in primary endocervical epithelial cells. 2010 to the paper
R&D mouse monoclonal anti-TLR4 antibody was used to perform western blot in order to study the immune defence role of TLR4 and HD5 in primary endocervical epithelial cells. more
total:2
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. 2005 to the paper
BioSource Europe SA anti-IL-12 (p40) antibody (which was in ELISA kit) was used in venous blood samples from human and in ELISA to study the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. more
total:1
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. 2006 to the paper
Alexis rabbit polyclonal anti-Nalp3 antibody (which recognizes WT, R260W, and D303N cryopyrins) was used in human cells and in immunocytochemistry to study the role of cryopyrin and pyrin in activating caspase-1.
total:68
UNC93B1 mediates differential trafficking of endosomal TLRs. 2013 to the paper
eBioscience anti-TNFa-PE or -APC antibody was used to perform flow cytometry in order to study the diffrent trafficking mechanisms of endosomal TLRs mediated by UNC93B1. more
total:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
Santa Cruz Biotechnology anti-STAT3 monoclonal antibody was used to perform western blot to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
total:5
CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles. 2007 to the paper
R&D Systems rat anti-mouse CCR6 antibody was used in flow cytometry to study the role for CCR6 in the development of isolated lymphoid follicles (ILFs). more
total:1
Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase. 2010 to the paper
Proteintech Group rabbit PolyAb anti-ITPA used to perform western blot in order to investigate the function of the human P32T ITPase
total:8
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Calbiochem rabbit polyclonal anti-PAR was used to perform immunoprecipitation in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:11
Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. 2010 to the paper
Biologo polyclonal rabbit anti-human HBD-2 was used to perform immunohistochemistry in dilution 1:100 and ELISA in dilution 1:1000 in order to show that the levels of human neutrophil peptides 1-3 secretion is inhibited by tumor necrosis factor and norepinephrine in mixed synovial tissue cultures from osteoarthritis and rheumatoid arthritis patients. more
total:1
Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. 2008 to the paper
J-F. Brunet rabbit Phox2b antibody (1:1000) was used in immunohistochemistry in order to demonstrate that Hand2 is a multifunctional DNA binding protein affecting differentiation and cell type-specific gene expression in neural crest-derived noradrenergic sympathetic ganglion neurons
total:13
Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth. 2008 to the paper
Santa Cruz Biotechnology anti-Tyk2 and anti-p-Tyk2 polyclonal antibodies were used to perform immunoprecipitation and western blot assays in order to demonstrate that Z3 is a novel specific inhibitor that can suppresses Jak2-mediated pathologic cell growth. more
total:80
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. 2010 to the paper
AbDSerotec PE-Cy5-conjugated anti-CD14 antibody was used to perform flow cytometry in order to study the role of the EPEC protein NleE in inhibiting NF-kappa B signaling in human dendritic cells. more
total:17
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-TRAF6 (H-274) monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
total:23
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
R&D Systems anti-IL-10 antibody was used to perform ELISA in order to study how gut microbiota regulate immunesystem. more
total:2
Epstein-Barr virus transcription activator Rta upregulates decoy receptor 3 expression by binding to its promoter.. 2007 to the paper
BioLegend DcR3 antibody was used in western blot to demonstrate enhanced DcR3 expression upon EBV reactivation in P3HR1 cells and in EBV-infected 293 cells. more
total:2
Nuclear hBD-1 accumulation in malignant salivary gland tumours. 2008 to the paper
Biologo hBD-1 antibody was used in immunohistochemistry in order to characterize proteins involved in cell cycle control more
total:4
Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis.. 2008 to the paper
Santa Cruz Biotechnology rabbit polyclonal TLR5 antibody (2 ug/ml) was used in western blot in order to study the role of toll-Like receptors in the pathogenesis of lyme neuroborreliosis more
total:20
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. 2009 to the paper
BD rat monoclonal antibodies against mouse Gr-l were used in flow immunocytometry to investigate the role of the migrant cDCs in the regulation of CD11c, MHC II, and CD86. more
total:30
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-1-beta mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
total:11
A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells. 2008 to the paper
R&D Systems monoclonal anti-CXCR3 was used to perform blocking or activating experiments in order to show that a computational-based peptidomics can be used to identify peptides inhibiting the proliferation and migration of endothelial cells systematically. more
total:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology MDR1 antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:28
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-PPAR gamma antibody was used to carry out western blot analysis and Ch-IP assays in order to identify the binding sites of PPAR Gramma and RXR in a genome wide manner during adipogenesis. more
total:34
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
Upstate anti-JAK2 antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
total:19
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
eBioscience anti-IL-17A mAb was used to perform flow cytometry and cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
total:1
IL-33 exacerbates antigen-induced arthritis by activating mast cells. 2008 to the paper
Axxora anti-IL-33 antibody was used in immunohistochemistry to study the role of the effect of IL-33 on mast cells in antigen-induced arthritis in paraffin sections from human synovial tissue.
total:23
Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. 2009 to the paper
Santa Cruz anti-TNFR1 antibody was used to perform western blot in order to study the mechanism that TRAF2 inhibits stress-induced cell death. more
total:14
Control of chemokine gradients by the retinal pigment epithelium. 2008 to the paper
Stressgen Bioreagents TNFR2 antibody was used in western blot in order to examine the physiological responses of human fetal retinal pigment epithelia (hfRPE) after polarized activation of proinflammatory cytokine receptors in vitro more
total:7
Identification of major histocompatibility complex class I C molecule as an attachment factor that facilitates coronavirus HKU1 spike-mediated infection. 2009 to the paper
Invitrogen Purified goat IgG was used as the isotypic controls in order to identify the MHC I molecule (HLA-C) as an attachment factor in facilitating HCoV-HKU1 spike (S) mediated infection. more
total:7
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-HLADR was used in 2ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
total:9
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 to the paper
Upstate anti-IgG antibody was used to perform RNA immunoprecipitation in order to analyze histone methylation at transcription start sites in human-specific prefrontal neurons of brain. more
total:6
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. 2011 to the paper
Santa Cruz anti-CTLA-4 antibody was used to perform immunocytochemistry in order to reveal the reason why CTLA-4 can inhibit CD28 stimulation. more
total:10
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. 2007 to the paper
Santa Cruz Biotechnology anti-Stat4 antibody was used in ChIP assay to define a mechanism for Stat4-dependent genetic programming of a Th1-associated gene. more
total:17
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
BD Pharmingen anti-IL-2 antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem. more
total:49
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. 2009 to the paper
eBioscience anti-CD25 antibody was used in flow cytometry in order to investigate the role of dendritic cells in the regulation of spontaneous fatal autoimmunity. more
total:22
Inflammatory role of Toll-like receptors in human and murine adipose tissue. 2010 to the paper
Hycult Biotechnologies monoclonal anti-TLR2 was used to perform ELISA in order to show that Toll-like receptors in human and murine adipose tissue participate omental adipose tissue-related inflammation. more
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:12
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. 2006 to the paper
Santa Cruz Biotechnology anti-Fas-L antibody was used in western blot to study the role of HYAL1-v1 in regulating in bladder cancer growth, infiltration, and angiogenesis in transfected human HT1376 bladder cancer cells. more
total:6
Expression of Toll-like receptors in verruca and molluscum contagiosum. 2008 to the paper
Santa Cruz Biotechnology goat polyclonal anti-human TLR9 was used in immunohistochemistry to study the expression of toll-like receptors in verruca and molluscum contagiosum in cryostat sections from human skin. more
total:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 to the paper
Santa Cruz anti-MCP-1 antibody was used to perform immunohistochemistry in order to study the effect of MCP1 and CD40 ligation on VEGF production. more
total:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
Affinity BioReagents anti-VDR (MA1-7101, 1:400) monoclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder. more
total:5
Lipocalin 2 promotes breast cancer progression. 2009 to the paper
R&D Systems anti-human Lcn2 antibody was used in immunohistochemistry to study the effect of Lipocalin 2 on breast cancer progression. more
total:62
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 to the paper
R&D Systems anti-IFN-gamma was used in 5ug/ml to perform cell stimulation in order to show that blood-brain barrier integrity and CNS immune quiescence were promoted by sonic hedgehog pathway. more
total:4
High prevalence of mannose-binding lectin (MBL) deficiency in premature neonates. 2006 to the paper
Sanquin biotinylated mouse-anti-MBL IgG 5E12 (10 ug/ml) was used in ELISA assay as the detection antibody to measure MBL in plasma to study the high prevalence of mannose-binding lectin (MBL) deficiency in premature neonates more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:12
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Calbiochem anti-osteopontin antibody (1:100) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
total:13
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
Abcam rabbit anti-IGF-1 antibody was used in western blot to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
total:1
Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio. 2006 to the paper
R&D Systems IL-1RA ELISA ket was used to study inflammatory response induced by glucan