colorectal neoplasms
gene
reagent
sample publication
sample review
total:20
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Oncogene Ras antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:24
Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men. 2008 to the paper
Calbiochem anti-MLH1 antibody (1:75) was used to perform western blot and immunoprecipitation in order to study the function of small ubiquitin-related modifier (SUMO) 1, SUMO-2/3 and SUMOylation. more
total:8
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-Braf antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:11
A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. 2009 to the paper
Calbiochem anti-APC was used to perform immunocytochemistry in order to show that MRP protein plays an important role in adherens junction formation and tumorigenesis more
total:18
Valproic acid resensitizes cisplatin-resistant ovarian cancer cells. 2008 to the paper
Transduction Laboratories anti-hMSH2 antibody was used in immunocytochemistry to show the effect of VPA and cisplatin on ovarian cancer cells. more
total:15
Lynch syndrome in women less than 50 years of age with endometrial cancer. 2008 to the paper
Zymed anti-human mouse MSH6 antibody was used to perform immunohistochemistry in order to show that women diagnosed with endometrial cancer before age 50 may have a mismatch repair deficiency. more
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
total:5
Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. 2010 to the paper
BD anti-pan-MCM antibody was used in western blot in order to investigate the mechanism of how the embryonic stem cells chromatin structure change was regulated by condensin complexes during mitotic progression. more
total:4
Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. 2007 to the paper
BD Bioscience anti-hMSH3 was used to perform western blot in order to show that in tumors the tranlation of some NMD-escape PTC-containing mRNAs could be repressed selectively. more
total:12
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. 2010 to the paper
Invitrogen anti-Smad7 was used to perform western blot in order to study the roles of RBBP9 as a tumor-associated serine hydrolase to pancreatic neoplasia more
total:2
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-DPYD was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:8
Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall. 2008 to the paper
Dako anti-Cytokeratin 20(Ks20.8) antibody was used to perform immunohistochemistry in order to study the spectrum of immunoreactivity with TdT in MCC. more
total:2
Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene. 2008 to the paper
Gentest anti-UGT1A antibody (1:500) was used in western blot to identify UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene. more
total:54
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Santa Cruz Biotechnology anti-COX-2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more
total:11
Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. 2010 to the paper
Santa Cruz Biotechnology anti-PMS2 antibody was used for western blot in order to investigate the roles of MutSalpha and MutLalpha in the regulation of ATR-Chk1 pathway. more
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:19
A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. 2009 to the paper
Abcam polyclonal anti-CD133 antibody was used for western blot in order to identify the role of MT1-MMP for the regulation of COX-2 expression in CD133 (+) U87 glioblastoma cells. more
total:9
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. 2009 to the paper
Sigma mouse GG-7 Fc-specific anti-human IgG antibody was used to confirm the presence of the Fc fragment of human IgG in order to illustrate that Toll-like receptor 4 (TLR4) plays a fundamental role in the sensing of LPS from Gram-negative bacteria. more
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
total:3
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-XPD was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
total:21
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
Santa Cruz rabbit anti-Smad4(H-552; 1:1,000) antibody was used to perform western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
total:45
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Neomarkers PTEN antibody was used to perform immunohistochemistry in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:32
Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin. 2006 to the paper
Upstate anti-Gal4 antibody was used to perform ChIP assays in order to sthudy the function of coiled-coil coactivator's N-terminal in regulating transcriptional activation. more
total:26
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
Calbiochem/Merck anti-H-Ras antibody was used to perform western blot in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
total:1
CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells. 2008 to the paper
BD Pharmingen Transduction Laboratories mouse monoclonal anti-CAS antibody (clone 24) was used in western blot and immunocytochemistry to study the different effect of CSE1L/CAS on invasion, metastasis, and proliferation of cancer cells.
total:123
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-Cyclin D1 antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:9
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 2010 to the paper
Santa Cruz Biotechnology anti-MMP7 antibody was used in immunohistochemistry to investigate the function of UPK1A in esophageal squamous cell carcinoma. more
total:2
Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. 2006 to the paper
Abgent rabbit anti-Gremlin(1:50) polyclonal antibody was used to perform immunohistochemistry in order to study the regulatory effects of highly expressed bone morphogenetic protein 4(BMP4) and Gremlin toward myogenic progenitor proliferation in human fetal skeletal muscle. more
total:11
Low-grade gastric adenomas/dysplasias: phenotypic expression, DNA ploidy pattern, and LOH at microsatellites linked to the APC gene. 2008 to the paper
Novocastra anti-Cdx2 monoclonal antibody(1:100) was used to perform immumohistochemistry in order to study phenotypic expression, DNA ploidy pattern, and LOH of the APC gene linked microsatellites. more
total:15
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. 2009 to the paper
Santa Cruz Biotechnology anti-TGFBR1 antibody was used to carry out western blot analysis in order to investigate the role for Smurf2 in promoting breast cancer metastasis. more
total:3
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. 2008 to the paper
Santa Cruz Biotechnologies anti-F1-ATPase was used to perform western blot in order to demonstrate that OS-9 and XTP3-B/erlectin are ER-resident glycoproteins that bind to ERAD substrates and, via the SEL1L adaptor, to the ER membrane-embedded ubiquitin ligase Hrd1. more
total:9
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. 2007 to the paper
Topogen mouse anti-TOP1 monoclonal antibody(1:50) was used to perform immunofluoresence in order to study the mechanism of genetic disease ataxia telangiectasia (AT) in the nucleus of human Purkinje neurons. more
total:3
Gamma-synuclein as a marker of retinal ganglion cells. 2008 to the paper
Santa Cruz Biotechnology gamma-synuclein antibody was used in ELISA in order to demonstrate that gamma-synuclein as a marker of retinal ganglion cells more
total:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology MDR1 antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:35
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.. 2010 to the paper
Santa Cruz anti-Flk-1 antibody was used to perform immunoprecipitation in order to reveal the critical role of prorenin receptor and vacuolar H+-ATPase-mediated acidification in Wnt signaling. more
total:5
Aberrant promoter methylation of SPARC in ovarian cancer. 2009 to the paper
Epigentek anti-DNMT3b antibody was used for ChIP assays in order to study the role of SPARC in therapeutic process for ovarian cancer. more
total:2
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients. 2008 to the paper
Lab Vision Corporation anti-GSTM antibody was used to perform immunocytochemistry in order to show that the expression of glutathione S-transferase pi is at a higher level in the brains of medically intractable epileptic patients. more
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
total:8
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. 2006 to the paper
Santa cruz biotechnology anti-Muc2 antibody was used to perform mmunohistochemistry assays in order to investigate the molecular regulation mechanisms of Smad4 in the process of normal pancreas development and pancreatic ductal adenocarcinomas (PDAC) growth. more
total:38
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. 2010 to the paper
Calbiochem anti-Hdm2 antibody was used for western blot in order to investigate the role of TGFB1 in the regulation of Mdm2 expression and late-stage breast cancer metastasis. more
total:12
A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. 2013 to the paper
Millipore anti-active-beta-catenin antibody was used to perform immunohistochemistry to study the role of Gcm1 and Fzd5 in regulating trophoblast differentiation and sites of chorionic branching morphogenesis. more
total:7
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity. 2008 to the paper
Oxford Biomedical Research anti-CYP2E1 antibody (1:1000) was used in western blot in order to study the role of cardiomyocyte CPR and CPR-dependent enzymes in doxorubicin (Dox) mediated acute cardiotoxicity more
total:1
Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. 2010 to the paper
Abcam anti-USP22 antibody was used to perform western blot in order to study the modulation of intracellular F. tularensis phagosome biogenesis and proliferation.
total:1
Cell-cell contact globally activates microRNA biogenesis. 2009 to the paper
Upstate anti-Ago antibody was used to perform western blot in order to study the association between the cell-cell contact and microRNA biogenesis.
total:2
Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer. 2007 to the paper
Santa Cruz Biotechnology polyclonal goat anti-rat-SC-1 antibody was used in immunohistochemistry to study the role for SPARC-like protein 1/Hevin in pancreatic cancer in paraffin sections from human tumor. more
total:2
Integrin-linked kinase regulates smooth muscle differentiation marker gene expression in airway tissue. 2008 to the paper
Proteintech Group polyclonal anti-human SM22 alpha antibody was used for western blot in order to show that ILK can regulate airway smooth muscle differentiation. more
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
total:27
Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon. 2009 to the paper
Dako Cytomation anti-pan-Cytokeratin antibody was used in immunohistochemistry to define the importance and role of cortactin in HNSCC tumor progression more
total:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
Affinity BioReagents anti-VDR (MA1-7101, 1:400) monoclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder. more
total:9
RAS transformation requires CUX1-dependent repair of oxidative DNA damage. 2014 to the paper
Pierce anti-OGG1 antibody was used to perform Western Blotting in order to study CUX1-dependent repair of RAS-induced senescence. more
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:13
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. 2008 to the paper
Novus anti-CLDN1 antibody 1C5-D9 was used in immunocytochemistry to study the role for protein kinase signaling in HCV infection more
total:2
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance. 2009 to the paper
BD Biosciences monoclonal anti-TRAP1 antibody was used carry out western blot analysis and immunofluorescence assays in order to analyze mitochondrial dysregulation of osteoarthritic human articular chondrocytes by proteomics. more
total:5
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz polyclonal anti-CDK8 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
total:24
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. 2009 to the paper
GeneTex mouse monoclonal anti-ER antibody (C14C8) was used in immunohistochemistry, immunocytochemistry, and immunoprecipitation to study the effect of estrogen receptormediated nuclear interaction between IRS-1 and Rad51 on homologous recombination directed DNA repair in medulloblastoma. more
total:7
ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal ABCC2 antibody (H-300) and goat polyclonal ABCC2 antibody (H-17) were used in immunocytochemistry (1:400) to study its localization in the nuclear membrane of ovarian carcinomas and its correlation with resistance to cisplatin and clinical outcome. more