colonic neoplasms
gene
reagent
sample publication
sample review
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
total:20
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Oncogene Ras antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:19
A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. 2009 to the paper
Abcam polyclonal anti-CD133 antibody was used for western blot in order to identify the role of MT1-MMP for the regulation of COX-2 expression in CD133 (+) U87 glioblastoma cells. more
total:1
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart. 2007 to the paper
Transduction Laboratory antibody against Nox-1 was used in western blot to detect Nox-1 expression in human myocardial tissues.
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:8
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-Braf antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:11
A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. 2009 to the paper
Calbiochem anti-APC was used to perform immunocytochemistry in order to show that MRP protein plays an important role in adherens junction formation and tumorigenesis more
total:120
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Calbiochem anti-SRC antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:6
Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. 2005 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-TRAIL antibody was used in western blot to investigate the role of human BVR in sodium arsenite (As) mediated induction of HO-1 and in cytoprotection against apoptosis by small interference RNA-mediated gene silencing. more
total:11
Low-grade gastric adenomas/dysplasias: phenotypic expression, DNA ploidy pattern, and LOH at microsatellites linked to the APC gene. 2008 to the paper
Novocastra anti-Cdx2 monoclonal antibody(1:100) was used to perform immumohistochemistry in order to study phenotypic expression, DNA ploidy pattern, and LOH of the APC gene linked microsatellites. more
total:9
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 2010 to the paper
Santa Cruz Biotechnology anti-MMP7 antibody was used in immunohistochemistry to investigate the function of UPK1A in esophageal squamous cell carcinoma. more
total:15
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Cell Signaling Technologies anti-PRKAA1 antibody was used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
total:2
Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells. 2005 to the paper
Seikagaku HSPG neo-epitope (exposed after heparitinase III digestion, clone 3G10) antibody was used in western blot to study thrombin-induced human vascular smooth muscle cell migration and proliferation more
total:1
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. 2007 to the paper
Oncogene Research Products SphK1 antibody was used in western blot to study the role of lipid phosphate phosphatase (LPP) 1 and sphingosine kinase1 (SphK1) in converting exogenous S1P to intracellular S1P.
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
total:2
eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. 2008 to the paper
Abcam rabbit anti-KLF4 antibody 1:15,000 was used for western blot in order to investigate the role of eIF4GI in the regulation of cell proliferation and autophagy. more
total:4
Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-?-TAK1-dependent mechanism. 2013 to the paper
Abcam HIPK2 antibody was used to perform ChIP in order to investigate the mechanism of the control of angiogenesis by transcriptional corepressors HIPK1 and HIPK2. more
total:49
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. 2013 to the paper
Millipore rat anti-heparan sulfate proteoglycan monoclonal antibody was used to perform immunohistochemistry in order to investigate the role of sFLT-1 in the maintenance of the avascular photoreceptor layer in mouse models. more
total:100
Plasma membrane contributes to the formation of pre-autophagosomal structures. 2010 to the paper
Abcam anti-AP1-A1 antibody was used to perform western blot in order to study the role of plasma membrane in the formation of preautophagosomal structures. more
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
total:1
Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. 2009 to the paper
Abcam polyclonal anti-CDX1 antibody was used in immunohistochemistry to study the effect of homeobox gene CDX1 on gastrointestinal differentiation marker cytokeratin 20
total:4
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. 2009 to the paper
Abcam antibodies against WNT1 were used in western blot and immunohistochemistry to investigate the role of WISP1 in the regulation of ATII cell hyperplasia and plasticity. more
total:178
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. 2012 to the paper
Abcam mouse anti-p21 antibody was used to perform western blot in order to study the mechanism through which doxorubicin suppressed tumor growth. more
total:15
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. 2010 to the paper
eBioscience rabbit polyclonal anti-DR5 antibody was used in flow cytometry in order to investigate the roles of Fas ligand and TRAIL in the regulation of murine thymic graft-versus-host disease. more
total:7
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis. 2009 to the paper
Millipore HK2 antibody was used to perform western blot in order to investigate the relations between hexokinase 2 and prognosis of breast cancer more
total:54
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Santa Cruz Biotechnology anti-COX-2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more
total:8
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Calbiochem rabbit polyclonal anti-PAR was used to perform immunoprecipitation in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:8
Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. 2006 to the paper
BD Biosciences antibody to total Mcm2 was used in western blot to examine the levels of total Mcm2 in HeLa cells. more
total:123
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-Cyclin D1 antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
total:8
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. 2006 to the paper
Santa cruz biotechnology anti-Muc2 antibody was used to perform mmunohistochemistry assays in order to investigate the molecular regulation mechanisms of Smad4 in the process of normal pancreas development and pancreatic ductal adenocarcinomas (PDAC) growth. more
total:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
Santa Cruz Biotechnology anti-STAT3 monoclonal antibody was used to perform western blot to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
total:5
Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. 2009 to the paper
Cell Signaling Technology rabbit polyclonal anti-LEF1 antibody was used to carry out western blot analysis and immunofluorescence assays in order to investigate the role for AEG1 in regulating Hepatocellular carcinoma pathogenesis. more
total:21
Histone deacetylase complexes promote trinucleotide repeat expansions. 2012 to the paper
Santa Cruz Biotechnology anti-HDAC3 antibody was used to perform western blot assay in order to identify novel histone deacetylase complexes that promote expansions of trinucleotide repeats. more
total:24
Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men. 2008 to the paper
Calbiochem anti-MLH1 antibody (1:75) was used to perform western blot and immunoprecipitation in order to study the function of small ubiquitin-related modifier (SUMO) 1, SUMO-2/3 and SUMOylation. more
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
total:2
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. 2009 to the paper
Upstate anti-SPRY2 antibody was used for western blot in order to investigate the role of BRAF in the regulation of RAF-MEK signaling pathway. more
total:235
Regulation of early adipose commitment by Zfp521. 2012 to the paper
Santa Cruz Biotechnology anti-MYC antibody was used to carry out western blot and immunoprecipitation assays in order to investigate the regulatory role of Zfp521 in determining the switch between the adipogenic and osteogenic lineages. more
total:8
Hela l-CaD is implicated in the migration of endothelial cells/endothelial progenitor cells in human neoplasms. 2007 to the paper
Sigma anti-gelsolin antibody was used to perform immunohistochemistry in order to show that the Hela /-CaD is involved with the migration of endothelial cells/endothelial progenitor cells in human neoplasms. more
total:70
Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. 2010 to the paper
Santa Cruz anti-Sp1 antibody was used to perform ChIP assay in order to study the regulatory function of Sp1 and KLF15 on basal transcription of the human LRP5 gene. more
total:6
Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. 2007 to the paper
Santa Cruz Biotechnology PAR2 antibody was used in immunohistochemistry to determine the expression and functions of PARs in the gallbladder epithelium. more
total:8
Curcumin suppresses PPARdelta expression and related genes in HT-29 cells. 2009 to the paper
Santa Cruz Biotechnology anti-PPAR5 antibody was used in western blot to investigate the role of curcumin in the regulation of the expression of PPARdelta, 14-3-3epsilon, and VEGF in HT-29 cells. more
total:12
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-DNMT1 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:3
Gamma-synuclein as a marker of retinal ganglion cells. 2008 to the paper
Santa Cruz Biotechnology gamma-synuclein antibody was used in ELISA in order to demonstrate that gamma-synuclein as a marker of retinal ganglion cells more
total:1
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
Santa Cruz anti-CYP24A1 (1:150) polyclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder.
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
total:13
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. 2008 to the paper
Novus anti-CLDN1 antibody 1C5-D9 was used in immunocytochemistry to study the role for protein kinase signaling in HCV infection more
total:2
USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin. 2009 to the paper
Bethyl Laboratories anti-USP7 antibody was used to perform immunohistochemistry in order to study the control of claspin stability. more
total:102
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. 2011 to the paper
Santa Cruz anti-BAX was used to perform western blot in order to show that chemotherapy is efficient for patients with high mitochondrial priming more
total:24
High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo. 2009 to the paper
Abcam anti-HDAC2 antibody was used to perform immunohistochemistry in order to study the association between the high class I HDAC activity and RelA/p65 activation in pancreatic cancer. more
total:21
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
Santa Cruz rabbit anti-Smad4(H-552; 1:1,000) antibody was used to perform western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
total:15
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Santa Cruz Biotechnology MDR1 antibody (1:500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:28
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. 2010 to the paper
Lab Vision anti-MUC1-C antibody was used to perform immunoprecipitation in order to study the interaction between MUC1-C and STAT1 pathway in poor prognosis human breast cancers. more
total:9
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. 2009 to the paper
Santa Cruz Biotechnology RACK1 monoclonal antibody was used to perform western blot and immunoprecipitation in order to demonstrate the key mechanisms that regulate p63 protein stability in vivo. more
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more
total:10
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. 2008 to the paper
Diaclone mouse monoclonal anti-DR4 antibody (B-N28) was used to perform western blot in order to study the function of the natural product honokiol. more
total:16
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. 2009 to the paper
Millipore anti-TRF2 antibody was used to perform immunohistochemistry in order to study the function of HP1 proteins in the alternative lengthening of telomeres-associated PML bodies by p53/p21. more
total:7
SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. 2009 to the paper
Santa Cruz Biotechnologies BAG1 antibody was used to perform western blot in order to show the role of SMD and NMD in myogenesis. more
total:21
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
Santa Cruz rabbit anti-Tgfbr2(C-16; 1:50; used with blocking peptide SC-220P; catalog no. SC-220) antibody was used to perform immunohistochemistry and western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
total:4
Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. 2008 to the paper
Santa Cruz Biotechnology anti-Snail1 was used to perform western blot in order to investigate the role of the tetraspanin TM4SF5 in contact inhibition and tumorigenesis. more
total:2
Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells. 2006 to the paper
Santa Cruz Biotechnology Gli-1 antibody was used in immunocytochemistry to determine whether the synthetic microRNAs (miRNA) could effectively target tumor cells. more
total:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
Affinity BioReagents anti-VDR (MA1-7101, 1:400) monoclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder. more
total:8
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. 2009 to the paper
Santa Curz anit-ROCK1 antibody was used to perform western blot to study the different roles of ROCK1 and ROCK2 in regulating keratinocyte adhesion and terminal differentiation. more
total:16
Genes associated with the tumour microenvironment are differentially expressed in cured versus primary chemotherapy-refractory diffuse large B-cell lymphoma. 2008 to the paper
Novocastra anti-Galectin-3 antibody was used to perform immunohistochemistry in order to study the diversity of gene expression profiles in tumours. more
total:2
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. 2010 to the paper
Cell Signaling anti-Axin2 antibody was used to perform western blot in order to study the roles of the fragile X mental retardation protein during the regulations of the proliferation and differentiation of adult neural stem/progenitor cells. more
total:15
Lynch syndrome in women less than 50 years of age with endometrial cancer. 2008 to the paper
Zymed anti-human mouse MSH6 antibody was used to perform immunohistochemistry in order to show that women diagnosed with endometrial cancer before age 50 may have a mismatch repair deficiency. more
total:21
Protein expression profiling in the spectrum of renal cell carcinomas. 2010 to the paper
Cell signaling mouse anti-Hsp27 antibody(1 ug/ml) was used to perform immunostaining in order to study the differentiation in renal cell carcinomas(RCC) followed by specific protein expression. more