bone neoplasms
gene
reagent
sample publication
sample review
EWS
EWS RNA binding protein 1
total:4
The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function. 2009 to the paper
Santa Cruz anti-FLI-1 C19 antibody was used in immunoprecipitation experiment in order to demonstrate transcription activation of EWS-FLI1 protein by binding microsatellite sequences. more
RUNX2
RUNX family transcription factor 2
total:16
Juvenile dermatomyositis calcifications selectively displayed markers of bone formation. 2009 to the paper
R&D Systems anti-Cbfa1 antibody was used to carry out immunohistochemistry assays in order to determine the presence of SIBLING protein and bone components in Juvenile Dermatomyositis pathologic calcifications. more
RANKL
TNF superfamily member 11
total:7
Differential expression of RANK, RANK-L, and osteoprotegerin by synovial fluid neutrophils from patients with rheumatoid arthritis and by healthy human blood neutrophils. 2007 to the paper
R&D Systems monoclonal anti-human OPG antibody was used in elisa to study differential expression of RANK, RANK-L, and osteoprotegerin from patients with rheumatoid arthritis. more
CCN3
cellular communication network factor 3
total:1
Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia. 2006 to the paper
R&D Systems goat anti-human NOV was used in western blot to detect the expression of NOV in human placenta during normal gestation (6 40 weeks) and in early pre-eclamptic and HELLP placentae from patients
TNFRSF11A
TNF receptor superfamily member 11a
total:2
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. 2009 to the paper
Abcam anti-RANK monoclonal antibody was used in western blot in order to demonstrate that Lyn can inhibit osteoclast formation. more
MMP13
matrix metallopeptidase 13
total:7
Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. 2010 to the paper
Santa Cruze Biotechnology anti-human MMP-13 polyclonal antibody was used for western blot in order to investigate the role of PGE2 on matrix metalloproteinase synthesis in chondrocytes. more
ACP5
acid phosphatase 5, tartrate resistant
total:1
Increased tartrate-resistant acid phosphatase (TRAP) expression in malignant breast, ovarian and melanoma tissue: an investigational study. 2006 to the paper
Novocastra Laboratories Ltd. TRAP monoclonal antibody against against the N-terminal portion of human TRAP (clone: 26E5, subtype: IgG2b) was used in immunocytochemistry and immunohistochemistry to study the TRAP expression in various malignant and benign breast, ovarian, and melanoma tissues.
DKK1
dickkopf WNT signaling pathway inhibitor 1
total:5
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. 2008 to the paper
Abcam goat anti-human Dkk-1 anti-body was used to perform immunohistochemistry in order to investigate the expression alteration of dickkopfs (Dkks) and kremen2 (Krm2) in gastrointestinal cancer. more
CD99
CD99 molecule (Xg blood group)
total:4
The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. 2008 to the paper
Zymed Laboratory anti-CD99 (O13) antibody was used to perform immunohistochemistry in order to study the diagnostic value of SYT-SSX detected by RT-PCR and FISH for synovial sarcoma. more
Fli-1
Fli-1 proto-oncogene, ETS transcription factor
total:8
EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. 2009 to the paper
Santa cruz anti-FLI1 antibody was used to perform ChIP assays in order to demonstrate that the expression of the dickkopf family in Ewing family tumor cells were affected by EWS/ETS. more
IGFBP5
insulin like growth factor binding protein 5
total:1
Interaction of insulin-like growth factor II (IGF-II) with multiple plasma proteins: high affinity binding of plasminogen to IGF-II and IGF-binding protein-3. 2005 to the paper
R&D Systems polyclonal antibody against IGFBP-5 was used in western blot to study the interaction of insulin-like growth factor II (IGF-II) with multiple plasma protein.
ezrin
total:27
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. 2012 to the paper
Cell Signaling anti-Ezrin antibody was used to perform immunoprecipitation in order to study NKCC1 modulation of glioma cell migration. more
osteoprotegerin
TNF receptor superfamily member 11b
total:2
Calcification of human vascular smooth muscle cells: associations with osteoprotegerin expression and acceleration by high-dose insulin. 2007 to the paper
R&D Systems sandwich ELISA kit in which mouse anti-human OPG was employed as capture antibody and a biotinylated goat anti-human OPG used for detection to determine the concentration of OPG in the conditional medium of human vascular smooth muscle cells. more
CXCR4
C-X-C motif chemokine receptor 4
total:39
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-CXCR4 was used in 3ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
TEL
ETS variant transcription factor 6
total:3
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. 2009 to the paper
Affinity Bioreagents anti-SMRT antibody was used in immunoprecipitation to investigate the role of NCoR/SMRT interactions in the regulation of inflammatory and anti-inflammatory signals in immunity and homeostasis. more
ROCK1
Rho associated coiled-coil containing protein kinase 1
total:8
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. 2009 to the paper
Santa Curz anit-ROCK1 antibody was used to perform western blot to study the different roles of ROCK1 and ROCK2 in regulating keratinocyte adhesion and terminal differentiation. more
Grp94
heat shock protein 90 beta family member 1
total:10
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. 2011 to the paper
Stressgen anti-GRP94 was used in 1/1000 to perform western blot in order to show that regulatory subunit of protein phosphatase 1 could be blocked by small molecule selectively. more
Cdk4
cyclin dependent kinase 4
total:44
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. 2010 to the paper
Millipore anti-CDK4 antibody was used to perform western blot in order to study the roles of the fragile X mental retardation protein during the regulations of the proliferation and differentiation of adult neural stem/progenitor cells. more
MDM2
MDM2 proto-oncogene
total:38
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. 2010 to the paper
Calbiochem anti-Hdm2 antibody was used for western blot in order to investigate the role of TGFB1 in the regulation of Mdm2 expression and late-stage breast cancer metastasis. more
C/EBPbeta
CCAAT enhancer binding protein beta
total:26
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. 2009 to the paper
Santa Cruz Biotechnology C/EBPbeta antibody was used in ChIP assay to study the regulation of aromatase transcription and estrogen biosynthesis in adipose stromal cells (ASCs). more
ITGA6
integrin subunit alpha 6
total:20
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 to the paper
Biolegend anti-CD49f-PE antibody was used to perform flow cytometry in order to study the properties induced by cell signaling by urokinase-type plasminogen activator receptor (uPAR) in breast cancer cells. more
prostate specific antigen
kallikrein related peptidase 3
total:18
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. 2008 to the paper
DAKO polyclonal anti-PSA antibody was used in immunohistochemistry in order to investigate mechanisms by which advanced prostate cancers maintain AR-mediated gene expression following castration more
integrin alpha v
integrin subunit alpha V
total:24
TGFBI expression is associated with a better response to chemotherapy in NSCLC. 2010 to the paper
Chemicon Interational anti-integrin alphavbeta3 monoclonal was used to perform flow cytometry in order to determine if this integrin influences TGFBI-mediated NSCLC cell susceptibility to chemotherapy. more
p53
tumor protein p53
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
BMP2
bone morphogenetic protein 2
total:8
A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization. 2008 to the paper
Santa Cruz Biotechnology anti-BMP2 antibody was used in immunohistochemistry to identify these TGFbeta family members in human endometrium, and to determine whether they are involved in human decidualization. more
p63
tumor protein p63
total:26
Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. 2014 to the paper
Santa Cruz Biotechnology anti-p63 antibody was used to perform immunohistochemistry in order to study TNFa/TNFR2 axis protective role for skin against DUOX1-mediated oxidative stress. more
VEGF
vascular endothelial growth factor A
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
AIM-1
aurora kinase B
total:23
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Rockland anti-pT232 Aurora B was used to perform immunocytochemistry in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
Smad2
SMAD family member 2
total:74
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. 2010 to the paper
Cell Signaling anti-Smad2 was used to perform western blot in order to study the roles of RBBP9 as a tumor-associated serine hydrolase to pancreatic neoplasia more
HER2
erb-b2 receptor tyrosine kinase 2
total:69
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. 2008 to the paper
Zymed Laboratories anti-c-erbB-2 antibody was used in immunohistochemistry to investigate the relationship between amphiregulin expression and liver metastases of colorectal cancer. more
XPG
ERCC excision repair 5, endonuclease
total:2
Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair. 2007 to the paper
Lab Vision mouse anti-XPG was used to perform western blot in order to investigate the role of XPC protein in the initiation of nucleotide excision repair. more
IGF-IR
insulin like growth factor 1 receptor
total:40
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
Santa Cruz Biotechnology PE-conjugated anti-IGF-1R antibody was used in flow cytometry to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
PDGFR alpha
platelet derived growth factor receptor alpha
total:14
PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. 2008 to the paper
Santa Cruz Biotechnology anti-PDGFRA antibody was used to perform Western Blot and immunohistochemistry in order to prove that the metastatic behavior of human colorectal cancer correlates with PDGFRalpha/beta expression. more
beta1 integrin
integrin subunit beta 1
total:85
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 to the paper
Biolegend anti-CD29-FITC antibody was used to perform flow cytometry in order to study the properties induced by cell signaling by urokinase-type plasminogen activator receptor (uPAR) in breast cancer cells. more
MCP-1
C-C motif chemokine ligand 2
total:14
Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. 2008 to the paper
Santa Cruz anti-MCP-1 antibody was used to perform immunohistochemistry in order to study the effect of MCP1 and CD40 ligation on VEGF production. more
Sox9
SRY-box transcription factor 9
total:6
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. 2010 to the paper
Chemicon rabbit anti-Sox9 antibody (1:1000) was used in immunocytochemistry in order to investigate the role of beta-catenin in the regulation of Kras dependent reprogramming of acini into PDA preneoplastic precursors in mice. more
EGFR
epidermal growth factor receptor
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
GNAS
GNAS complex locus
total:4
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 to the paper
United States Biological rabbit anti-GNAS antibody was used to carry out immunoprecipitation assays in order to investigate the role for the stereochemistry of beta2-adrenoceptor agonist fenoterol in determining receptor-G protein selectivity and downstream signaling. more
CXCL12
C-X-C motif chemokine ligand 12
total:8
PTCH1 +/- dermal fibroblasts isolated from healthy skin of Gorlin syndrome patients exhibit features of carcinoma associated fibroblasts. 2009 to the paper
Abcam rabbit polyclonal anti-SDF1 alpha (alias CXCL12) antibody was used in western blot in order to demonstrate that PTCH1+/- genotype of healthy NBCCS fibroblasts is associated with basal cell carcinoma (BCC). more
NPM1
nucleophosmin 1
total:11
Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. 2010 to the paper
Zymed anti-NPM antibody was used for western blot in order to investigate the role for activated Bax in the regulation of p53-dependent, transcription-independent neural precursor cell apoptosis. more
c-Jun
Jun proto-oncogene, AP-1 transcription factor subunit
total:100
Plasma membrane contributes to the formation of pre-autophagosomal structures. 2010 to the paper
Abcam anti-AP1-A1 antibody was used to perform western blot in order to study the role of plasma membrane in the formation of preautophagosomal structures. more
MIR34A
microRNA 34a
STAT3
signal transducer and activator of transcription 3
total:120
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. 2010 to the paper
Santa Cruz Biotechnology anti-STAT3 monoclonal antibody was used to perform western blot to study the role of tyrosine kinase Tec in the generation of CD44highCD62L- Th17 subset. more
HDAC1
histone deacetylase 1
total:54
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Upstate Biotechnology anti-HDAC1 antibody was used to perform western blot in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs. more
beta-catenin
catenin beta 1
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
HIF-1 alpha
hypoxia inducible factor 1 subunit alpha
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
Cx43
gap junction protein alpha 1
total:20
CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus. 2009 to the paper
Santa Cruz Biotech polyclonal goat anti-connexin 43 antibody was used in immunohistochemistry in order to demonstrate that the normal human cornea is equipped with a molecular tool to actively metabolize NAD+, helping maintain corneal homeostasis more
MICA
MHC class I polypeptide-related sequence A
total:3
Opposing effects of interferon-alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors. 2008 to the paper
R&D Systems anti-MICA antibody was used to perform flow cytometry in order to study the differential effects of IFN-alpha and IFN-gamma on tumor cells. more
calcium sensing receptor
total:4
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. 2007 to the paper
Novus anti-FIH was used in western blot to investigate the interaction between ASB4 and FIH in human HEK-293T cells. more
endothelin 1
total:9
Expression of endothelial nitric oxide synthase and endothelin-1 in skin tissue from amputated limbs of patients with complex regional pain syndrome. 2008 to the paper
R&D systems rat anti-human ET-1 antibody (3G10) was used in immunohistochemistry to examine the distribution of eNOS and ET-1 in relation to vascular density represented by the endothelial marker CD31-immunoreactivity in skin tissue from amputated limbs of patients with CRPS. more
erbB3
erb-b2 receptor tyrosine kinase 3
total:18
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth. 2009 to the paper
Neomarkers ErbB-3 mouse monoclonal antibody was used to carry out antibody blocking assays in order to investigate the signal cross talk between ErbB2 and PR receptor and the effect on breast cancer growth. more
MMP-1
matrix metallopeptidase 1
total:13
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 to the paper
Calbiochem anti-MMP-1 monoclonal antibody was used to perform western blot in order to study the role of CD147 promoted myofibroblast differentiation in tissue remodeling. more
heparanase
total:6
Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery. 2009 to the paper
Abgent anti-HPSE rabbit antibody (1:200) was used to perform western blot in order to study how to modulate gene expression and develop new drugs by short chain fatty acid (SCFA) hexosamine molecules. more
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
BMI1
BMI1 proto-oncogene, polycomb ring finger
total:7
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Upstate Biotechnology anti-Bmi-1 antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
MMP-2
matrix metallopeptidase 2
total:37
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion. 2009 to the paper
Santa Cruz monoclonal MMP-2 antibodies were used in western blot in order to investigate the role of matrix metalloproteinase-2 (MMP-2) gene in invasiveness and adhesion of human pancreatic cancer cell line, BxPC-3. more
IL-6
interleukin 6
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
PTGS2
prostaglandin-endoperoxide synthase 2
total:54
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. 2009 to the paper
Santa Cruz Biotechnology anti-COX-2 antibody was used for western blot in order to investigate the role of mPGES-1 in the regulation of tumour growth, invasion, and metastasis. more
type I collagen
collagen type I alpha 1 chain
total:21
Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. 2010 to the paper
Abcam anti-collagen I antibody was used to perform immunohistochemistry and immunocytochemistry in order to study the mechanism by which Angiotensin-(1-7) inhibited CAF growth and reduced tumour fibrosis in orthotopic breast tumors. more
FGF-2
fibroblast growth factor 2
total:20
Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. 2009 to the paper
Chemicon rabbit polyclonal anti-FGF2 antibody was used in western blot to study the role for endothelial-derived FGF2 in the progression of pulmonary hypertension in humans and rodents. more
survivin
baculoviral IAP repeat containing 5
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
cyclin D1
total:123
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-Cyclin D1 antibody was used to perform western blot in order to study how ING1a induces senescence. more
connective tissue growth factor
cellular communication network factor 2
total:11
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Santa Cruz Biotechnologies CTGF antibody (1:2,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
FAK
protein tyrosine kinase 2
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
p50
nuclear factor kappa B subunit 1
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
p21
cyclin dependent kinase inhibitor 1A
total:178
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. 2012 to the paper
Abcam mouse anti-p21 antibody was used to perform western blot in order to study the mechanism through which doxorubicin suppressed tumor growth. more
p110
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
C-kit
KIT proto-oncogene, receptor tyrosine kinase
total:42
Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell. 2012 to the paper
NeoMarkers mouse anti-human CD117 monoclonal antibody was used to perform immunohistochemistry in order to analyze the cellular origin of adult functional blood vessels. more
mTOR
mechanistic target of rapamycin kinase
total:33
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Santa Cruz polyclonal anti-mTOR (N-19 (alpha-FRAP) was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
caveolin-1
caveolin 1
total:60
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature. 2009 to the paper
Epitomics anti-calveolin-1 antibody was used for immunohistochemistry in order to show that a novel translocation involving chromosome 19 causes Xp11.2 translocation renal cell carcinoma. more
GSK3beta
glycogen synthase kinase 3 beta
total:79
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. 2012 to the paper
Santa Cruz Biotechnology anti-GSK3 beta antibody was used to perform western blot in order to investigate the role of GSK3-TIP60-ULK1 signaling pathway in autophagy. more
AURKA
aurora kinase A
total:15
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Cell Signaling Technology anti-AURKA monoclonal antibody was used to study its relation between RHAMM by immunobloting. more
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit
total:3
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-XPD was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
c-Met
MET proto-oncogene, receptor tyrosine kinase
total:30
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues. 2009 to the paper
R&D rabbit anti-pMET antibody was used to perform immunohistochemistry in order to study the function of the fixative in the immunohistochemical detection of phosphoproteins. more
CD133
prominin 1
total:19
A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. 2009 to the paper
Abcam polyclonal anti-CD133 antibody was used for western blot in order to identify the role of MT1-MMP for the regulation of COX-2 expression in CD133 (+) U87 glioblastoma cells. more
integrin beta3
integrin subunit beta 3
total:28
Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression. 2010 to the paper
Santa Cruz Biotechnology mouse monoclonal integrin beta3 antibody (1:1000) was used in western blot in order to study the role of activated state of p42/44 and p38 in MMP-13 expression. more
IDH1
isocitrate dehydrogenase (NADP(+)) 1
total:1
Quiescent fibroblasts exhibit high metabolic activity. 2010 to the paper
Lifespan Biosciences anti-IDH1 antibody was used to perform western blot in order to study the function of quiescent fibroblasts.
c-Myc
MYC proto-oncogene, bHLH transcription factor
total:235
Regulation of early adipose commitment by Zfp521. 2012 to the paper
Santa Cruz Biotechnology anti-MYC antibody was used to carry out western blot and immunoprecipitation assays in order to investigate the regulatory role of Zfp521 in determining the switch between the adipogenic and osteogenic lineages. more
UBC
ubiquitin C
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
osteopontin
secreted phosphoprotein 1
total:12
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Calbiochem anti-osteopontin antibody (1:100) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
MMP-9
matrix metallopeptidase 9
total:45
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 to the paper
Epitomics anti-MMP-9 antibody was used in immunohistochemistry to study the mechanism of protein kinase D1 for inhibiting breast tumour cell invasion. more
CTLA 4
cytotoxic T-lymphocyte associated protein 4
total:6
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. 2011 to the paper
Santa Cruz anti-CTLA-4 antibody was used to perform immunocytochemistry in order to reveal the reason why CTLA-4 can inhibit CD28 stimulation. more
androgen receptor
total:52
Overcoming mutation-based resistance to antiandrogens with rational drug design. 2013 to the paper
Upstate anti-AR (PG-21) antibody was used to perform ChIP in order to study the rational drug design for castration-resistant prostate cancer without mutation-based resistance to antiandrogens. more
CD44
CD44 molecule (Indian blood group)
total:49
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. 2013 to the paper
Millipore rat anti-heparan sulfate proteoglycan monoclonal antibody was used to perform immunohistochemistry in order to investigate the role of sFLT-1 in the maintenance of the avascular photoreceptor layer in mouse models. more
Bcl 2
BCL2 apoptosis regulator
total:130
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Santa Cruz anti-Bcl-2 antibody (C-2, sc-7382, 1:500) was used to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
E-cadherin
cadherin 1
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more