asthma
gene
reagent
sample publication
sample review
IL-13
interleukin 13
total:10
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
BD Pharmingen anti-IL-13 antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem. more
ADAM33
ADAM metallopeptidase domain 33
total:1
ADAM33 gene silencing by promoter hypermethylation as a molecular marker in breast invasive lobular carcinoma. 2009 to the paper
Sigma polyclonal antibody against the catalytic domain of ADAM33 was used in western blot to investigate the role of ADAM33 in the regulation of tumor progression and metastasis in breast cancer.
ADRB2
adrenoceptor beta 2
total:7
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 to the paper
Santa Cruz Biotechnology anti-ADRB2 C-tail antibody was used to carry out western blot analysis in order to investigate the role for the stereochemistry of beta2-adrenoceptor agonist fenoterol in determining receptor-G protein selectivity and downstream signaling. more
ORMDL3
ORMDL sphingolipid biosynthesis regulator 3
IL-4
interleukin 4
total:19
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 to the paper
R&D Systems anti-IL-4 was used in 5ug/ml to perform cell stimulation in order to show that blood-brain barrier integrity and CNS immune quiescence were promoted by sonic hedgehog pathway. more
CD14
CD14 molecule
total:80
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. 2010 to the paper
AbDSerotec PE-Cy5-conjugated anti-CD14 antibody was used to perform flow cytometry in order to study the role of the EPEC protein NleE in inhibiting NF-kappa B signaling in human dendritic cells. more
eotaxin
C-C motif chemokine ligand 11
total:4
Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. 2006 to the paper
R&D Systems anti-eotaxin antibody (which was in ELISA kit) was used in serum from human and in ELISA to study the correlation of elevated serum monocyte chemoattractant protein-4 and chronic inflammation with obesity. more
IL33
interleukin 33
total:1
IL-33 exacerbates antigen-induced arthritis by activating mast cells. 2008 to the paper
Axxora anti-IL-33 antibody was used in immunohistochemistry to study the role of the effect of IL-33 on mast cells in antigen-induced arthritis in paraffin sections from human synovial tissue.
CHIA
chitinase acidic
total:1
Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells. 2008 to the paper
MedImmune polyclonal rabbit anti-human AMCase antibody or monocloncal rabbit anti-mouse AMCase antibody (1:100) was used to perform western blot and immunohistochemistry in order to study the mechanisms that control epithelial cell AMCase secretion and its effector responses.
ST2
interleukin 1 receptor like 1
total:3
IL-33 mediates inflammatory responses in human lung tissue cells. 2010 to the paper
R&D Systems anti-ST2/IL1R4 antibody was used in western blot to study the role of IL-33 in inflammatory responses in human lung tissue cells. more
CRTH2
prostaglandin D2 receptor 2
total:1
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. 2009 to the paper
Miltenyi Biotec anti-CRTH2-PE antibody was used to carry out flow cytometry analysis in order to investigate the mechanism for IL-33 in promoting allergic inflammation.
STAT6
signal transducer and activator of transcription 6
total:15
Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells. 2009 to the paper
Santa Cruz anti-Stat6 antibody was used to perform western blot in order to show that IRF-4 and IRF-8 can increase telomerase activity. more
IL18R1
interleukin 18 receptor 1
total:2
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. 2009 to the paper
R&D Systems anti-IL-18R-PE antibody was used to carry out flow cytometry analysis in order to investigate the mechanism for IL-33 in promoting allergic inflammation. more
FCER1A
Fc fragment of IgE receptor Ia
total:8
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. 2011 to the paper
eBioscience biotin-anti-Fc epsilon RI alpha antibody was used to perform flow cytometry in order to study the role of eosinophils in metabolic homeostasis. more
FLG
filaggrin
total:5
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. 2010 to the paper
Babco anti-filaggrin antibody was used for western blot in order to investigate the role of N-WASP in the regulation of Wnt signaling and hair follicle cycling in mice. more
RANTES
C-C motif chemokine ligand 5
total:14
Ex vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice. 2009 to the paper
Chemicon anti-alpha5 antibody was used to incubate the human CD34+ cells for 30 minutes at 4- in order to investigate the role of beta4 integrin, alpha5 integrin, and CXCR4 in cytokine-treated human cord blood CD34+ cells. more
IL-17
interleukin 17A
total:19
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
eBioscience anti-IL-17A mAb was used to perform flow cytometry and cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
TGF-beta1
transforming growth factor beta 1
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
TIMD4
T cell immunoglobulin and mucin domain containing 4
CHI3L1
chitinase 3 like 1
total:2
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. 2008 to the paper
R&D Systems goat polyclonal anti-human chitinase 3-like 1 antibody was used in western blot and immunohistochemistry to study the role for YKL-40 in modulating the biological activity of basic fibroblast growth factor. more
ARG1
arginase 1
total:2
Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-arginase 1 antibody was used in western blot and immunohistochemistry to study the role for elevated arginase expression in HCV associated HCC more
CD23
Fc fragment of IgE receptor II
total:11
TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. 2009 to the paper
BD Pharmingen anti-CD23 antibody was used in flow cytometry in order to study the role for TRAF6 in T cell-dependent and T cell-independent humoral immune responses. more
GSTP1
glutathione S-transferase pi 1
total:9
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. 2009 to the paper
Sigma mouse GG-7 Fc-specific anti-human IgG antibody was used to confirm the presence of the Fc fragment of human IgG in order to illustrate that Toll-like receptor 4 (TLR4) plays a fundamental role in the sensing of LPS from Gram-negative bacteria. more
IL13RA1
interleukin 13 receptor subunit alpha 1
total:3
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. 2008 to the paper
R&D Systems anti-IL-13Ralpha1 antibody was used for flow cytometry to elucidated the role of IL-4 and IL-13 in regulates relative cytokine sensitivity. more
ALOX5
arachidonate 5-lipoxygenase
total:6
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. 2010 to the paper
Santa Cruz Biotechnology anti-5-LOX antibody was used to perform western blotting in order to study how the cell growth are promoted by research on a mutant of HBx. more
T bet
T-box transcription factor 21
total:1
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
Becton Dickinson anti-TBET antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem.
glucocorticoid receptor
nuclear receptor subfamily 3 group C member 1
total:20
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. 2009 to the paper
BD rat monoclonal antibodies against mouse Gr-l were used in flow immunocytometry to investigate the role of the migrant cDCs in the regulation of CD11c, MHC II, and CD86. more
IRF-1
interferon regulatory factor 1
total:14
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 to the paper
Santa Cruz Biotechnology anti-IRF-1 antibody was used to perform western blot and immunohistochemical in order to study epstein-barr virus (EBV) infection of human B lymphocytes with interferon regulatory factor 4 (IRF-4). more
TARC
C-C motif chemokine ligand 17
total:2
Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). 2007 to the paper
Shionogi murine monoclonal TARC antibody was used in ELISA to investigate the clinical significance of serum thymus and activation-regulated chemokine (TARC) in children with atopic dermatitis (AD). more
GSTM1
glutathione S-transferase mu 1
total:2
Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients. 2008 to the paper
Lab Vision Corporation anti-GSTM antibody was used to perform immunocytochemistry in order to show that the expression of glutathione S-transferase pi is at a higher level in the brains of medically intractable epileptic patients. more