TGFBR1 KD Mutants in Cancer
gene
reagent
sample publication
sample review
total:235
Regulation of early adipose commitment by Zfp521. 2012 to the paper
Santa Cruz Biotechnology anti-MYC antibody was used to carry out western blot and immunoprecipitation assays in order to investigate the regulatory role of Zfp521 in determining the switch between the adipogenic and osteogenic lineages. more
total:13
Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. 2008 to the paper
Cell Signaling Technology anti-pY774-c-Cbl antibody was used to carry out western blot analysis in order to investigate the mechanism for Lyn kinase regulating imatinib sensitivity in chronic myelogenous leukemia cells. more
total:5
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. 2008 to the paper
Santa Cruz anti-cyclin T1 antibody was used to perform western blot in order to study the association between ING4 and the activity of NF-kappa B molecules bound with target gene promoters. more
total:5
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz polyclonal anti-CDK8 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
total:11
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz polyclonal anti-CDK9 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
total:1
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 to the paper
Santa Cruz anti-p15 was used to perform western blot in order to show the role of cyclin K and cyclin D1b in multiple myeloma.
total:11
In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis. 2009 to the paper
Abcam rabbit anti-CHIP was used to perform western blot in order to show that enhancing CHIP activity is good for therapy for SCA3 or other polyQ diseases more
total:11
Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. 2007 to the paper
Santa Cruz anti-E2F4 was used to perform ChIP assays in order to show that the evolutionarily conserved gene targets of E2F4 play important roles for cell cycle. more
total:8
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. 2011 to the paper
Affinity Bioreagents anti-FKBP12 was used to perform western blot in order to show that unfolded protein response is induced by Ire1-unfolded protein interaction. more
total:7
Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. 2009 to the paper
Thermo Fisher Scientific anti-furin antibody was used in immunocytochemistry in order to investigate the mechanism of the autonomous cholesterol regulation activated by adenovirus membrane protein RID-alpha. more
total:5
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. 2011 to the paper
ProteinTech Group anti-PPP1R15A/GADD34 was used in 1/1000 to perform western blot in order to show that regulatory subunit of protein phosphatase 1 could be blocked by small molecule selectively. more
total:54
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Upstate Biotechnology anti-HDAC1 antibody was used to perform western blot in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs. more
total:9
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. 2010 to the paper
Santa Cruz Biotechnology anti-JunB antibody was used for western blot in order to investigate the roles of MDA5 and PTPN2 in the regulation of pancreatic cell responses to the viral by-product double-stranded RNA. more
total:2
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Bethyl Laboratories anti-menin antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:1
The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. 2009 to the paper
Abgent anti-MTMR4 antibody was used to perform western blot in order to study the role of Nedd4 plays in the biological process of muscle breakdown.
total:14
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Upstate Biotechnology anti-p300 antibody was used to perform western blot in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs. more
total:7
CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. 2007 to the paper
Axxora Nedd8 antibody was used in western blot to demonstrate that CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. more
total:8
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Santa Cruz anti-p107 antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:16
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. 2010 to the paper
Novus Biologicals goat anti-human plasminogen antibody was used to perform ELISA in order to investigate the interaction between leptospiral endostatin-like protein A and human plasminogen. more
total:175
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Abcam anti-PARP1 was used to perform western blot in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:25
Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. 2010 to the paper
Invitrogen anti-PKC-zeta (1:500) antibody was used in western blot in order to investigate the role of PKM-zeta on neuropathic pain hypersensitivity in cortex. more
total:19
Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. 2008 to the paper
Santa Cruz anti-PP1alpha was used to perform western blot in order to show that SRC-3/AIB1 coactivator function and turnover is regulated by essential phosphatases and a phospho-degron of SRC-3/AIB1 is primary determinants of its turnover. more
total:2
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. 2007 to the paper
Santa Cruz Biotechnology goat polyclonal PP1 gamma C antibody was used in western blot to study the regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma more
total:49
Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo. 2010 to the paper
Santa Cruz anti-RhoA antibody was used to perform immunohistochemistry in order to study the effect of silencing of RhoA and RhoC expression on human colorectal carcinoma growth in vivo. more
total:5
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 2009 to the paper
Santa Cruz Biotechnology anti-ubiquitin antibody was used in western blot in order to identify a novel complex of erasin-ubiquilin-p97/VCP and its function in ERAD. more
total:74
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. 2010 to the paper
Cell Signaling anti-Smad2 was used to perform western blot in order to study the roles of RBBP9 as a tumor-associated serine hydrolase to pancreatic neoplasia more
total:51
Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation. 2009 to the paper
Zymed Smad3 polyclonal antibody was used in western blot in order to investigate the role of BMP9 signalling via ALK2/Smad1/Smad4 pathway in ovarian cancer. more
total:21
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
Santa Cruz rabbit anti-Smad4(H-552; 1:1,000) antibody was used to perform western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
total:12
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. 2010 to the paper
Invitrogen anti-Smad7 was used to perform western blot in order to study the roles of RBBP9 as a tumor-associated serine hydrolase to pancreatic neoplasia more
total:11
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Affinity Bioreagents anti-SMRT antibody was used to perform western blot in order to show that IRF5 mediates the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs. more
total:3
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. 2009 to the paper
Santa Cruz Biotechnology anti-Smurf1 antibody was used to carry out western blot analysis and immunohistochemistry assays in order to investigate the role for Smurf2 in promoting breast cancer metastasis. more
total:3
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. 2009 to the paper
Santa Cruz Biotechnology anti-Smurf2 antibody was used to carry out western blot analysis and immunohistochemistry assays in order to investigate the role for Smurf2 in promoting breast cancer metastasis. more
total:5
Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. 2013 to the paper
Santa Cruz anti-SnoN antibody was used to perform western blot to study the role of BMP-Smad signaling during motor axon extension. more
total:70
Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. 2010 to the paper
Santa Cruz anti-Sp1 antibody was used to perform ChIP assay in order to study the regulatory function of Sp1 and KLF15 on basal transcription of the human LRP5 gene. more
total:1
Absence of gemin5 from SMN complexes in nuclear Cajal bodies. 2007 to the paper
Dr. Glenn E Morris (RJAH Orthopaedic Hospital) rabbit antiserum against unrip was used in western blot and immunocytochemistry to study the absence of gemin5 from SMN complexes in nuclear Cajal bodies
total:1
Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner. 2005 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-DP-1 antibody was used in western blot to identify and Characterize the novel isoforms of human DP-1.
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
total:15
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. 2009 to the paper
Santa Cruz Biotechnology anti-TGFBR1 antibody was used to carry out western blot analysis in order to investigate the role for Smurf2 in promoting breast cancer metastasis. more
total:21
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. 2008 to the paper
Santa Cruz rabbit anti-Tgfbr2(C-16; 1:50; used with blocking peptide SC-220P; catalog no. SC-220) antibody was used to perform immunohistochemistry and western blot in order to study the dynamical regulation of TGF-beta signaling during late lung development in the human and mouse. more
total:1
Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells. 2005 to the paper
Santa Cruz Biotechnology anti-TGIF antibody was used in western blot to study the effects of 9-cis-RA on glomerular mesangial cell activation induced by transforming growth factor (TGF) beta1.
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:1
Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. 2007 to the paper
Boston Biochem anti-UbcH5 antibody was used to perform immunoprecipitation in order to study the roles of the DET1 during the regulation of the Cul4A activity.
total:1
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. 2010 to the paper
Abcam anti-UbcH5c antibody was used to perform western blot in order to study the mechanism of A20 action in the inhibition of NF-kappaB signaling.
total:34
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. 2009 to the paper
Cell Signaling Technology mouse anti-ubiquitin monoclonal antibody was used in western blot in order to demonstrate that BCL6 interacts with HB-EGF-CTF and that this interaction might induce the cyclin D2 expression in human gastric cancer. more
total:1
CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. 2007 to the paper
Abnova USP15 antibody was used in western blot to demonstrate that CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.
total:7
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. 2009 to the paper
Santa Cruz Biotechnology CRM-1 antibody was used for Western blotting in order to investigate the effect of LKB1 on nucleocytoplasmic transport. more
total:1
The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells. 2005 to the paper
Santa Cruz Biotechnology goat anti-SARA (N-20) antibody was used in immunoprecipitation and western blot to study the role of internalization in transforming growth factor 1-induced smad2 association with smad anchor for receptor activation (SARA) and smad2-dependent signaling in human mesangial cells