Signal transduction by L1
gene
reagent
sample publication
sample review
beta1 integrin
integrin subunit beta 1
total:85
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 to the paper
Biolegend anti-CD29-FITC antibody was used to perform flow cytometry in order to study the properties induced by cell signaling by urokinase-type plasminogen activator receptor (uPAR) in breast cancer cells. more
CD41
integrin subunit alpha 2b
total:13
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-CD41 was used in 1ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
CD56
neural cell adhesion molecule 1
total:56
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. 2012 to the paper
eBioscience anti-CD56 eFluor780 was used to perform flow cytometry in order to show that commensal bacteria was restricted in specific sites by innate lymphoid cells more
CSNK2A1
casein kinase 2 alpha 1
total:9
Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. 2010 to the paper
Santa-Cruz Biotechnology anti-CK2 alpha antibody was used to carry out western blot analysis in order to investigate the role for NF-kB transcription factor in the interleukin-1 induced expression of C/EBP delta and APP genes. more
CSNK2A2
casein kinase 2 alpha 2
total:4
Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. 2010 to the paper
Santa-Cruz Biotechnology anti-CK2 alpha' antibody was used to carry out western blot analysis in order to investigate the role for NF-kB transcription factor in the interleukin-1 induced expression of C/EBP delta and APP genes. more
CSNK2B
casein kinase 2 beta
total:2
CK2beta is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation. 2009 to the paper
Santa Cruz anti-CK2B antibody was used to perform western blot and immunohistochemistry in order to show the role of CK2B in apoptosis resistance and cell proliferation in endometrial carcinoma. more
EGFR
epidermal growth factor receptor
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
ERK1
mitogen-activated protein kinase 3
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more
ERK2
mitogen-activated protein kinase 1
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
FGFR1
fibroblast growth factor receptor 1
total:17
Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement. 2012 to the paper
Biosource International anti-FGFR-1 (pYpY653/654) antibodies were used to perform western blot and ELISA analyses in order to study the effect of the facilitation of AMPA receptor synaptic delivery on cognitive enhancement. more
integrin alpha v
integrin subunit alpha V
total:24
TGFBI expression is associated with a better response to chemotherapy in NSCLC. 2010 to the paper
Chemicon Interational anti-integrin alphavbeta3 monoclonal was used to perform flow cytometry in order to determine if this integrin influences TGFBI-mediated NSCLC cell susceptibility to chemotherapy. more
integrin alpha5
integrin subunit alpha 5
total:30
The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis. 2008 to the paper
Chemicon monoclonal anti-alpha5 was used to perform blocking experiments in order to show that integrins could interact with CXCL4 and play a role in angiogenesis. more
integrin beta3
integrin subunit beta 3
total:28
Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression. 2010 to the paper
Santa Cruz Biotechnology mouse monoclonal integrin beta3 antibody (1:1000) was used in western blot in order to study the role of activated state of p42/44 and p38 in MMP-13 expression. more
ITGA9
integrin subunit alpha 9
total:5
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. 2009 to the paper
Proteintech Group anti-RLC antibody was used to perform western blot in order to study the assemble of mammalian nonmuscle myosin II in live cells. more
MEK1
mitogen-activated protein kinase kinase 1
total:57
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Cell Signaling Technology anti-MEK1 antibody was used to perform flow cytometry and immunochemistry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
MEK2
mitogen-activated protein kinase kinase 2
total:16
A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. 2010 to the paper
Cell Signaling Technologies anti-phospho-MEK1/2 antibody was used to perform western blot in order to study the discrimination between the yeast and hyphal forms of C. albicans in epithelial cells via a biphasic MAPK response. more
neuropilin 1
total:7
Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts. 2007 to the paper
Santa Cruz Biotechnology NRP-1 antibody was used in western blot and immunohistochemistry to study the role of placenta growth factor in malignancy. more
PAK1
p21 (RAC1) activated kinase 1
total:29
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Epitomics rabbit monoclonal anti-Pak1 antibody was used in western blot to identify Pak4 as a novel Gab1-interacting protein downstream from the Met receptor and to study its function. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more