Resolution of Sister Chromatid Cohesion
gene
reagent
sample publication
sample review
AIM-1
aurora kinase B
total:23
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Rockland anti-pT232 Aurora B was used to perform immunocytochemistry in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
BUB1
BUB1 mitotic checkpoint serine/threonine kinase
total:2
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Chemicon mouse monoclonal anti-Bub1 antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B
total:6
Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors. 2010 to the paper
BD Transduction Laboratories anti-BUB1B antibody was used in western blot in order to investigate the different expression levels of spindle proteins in the testicular germ cell tumors. more
BUB3
BUB3 mitotic checkpoint protein
total:2
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
BD Transduction Laboratories monoclonal anti-BUB3 antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
CCNB2
cyclin B2
total:1
Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. 2007 to the paper
Santa Cruz Biotechnology cyclin B2 antibody was used in western blot to demonstrate the opposing roles of distinct mammalian SWI/SNF chromatin remodeling complexes in cell-cycle control.
Cdc2
cyclin dependent kinase 1
total:52
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Cdk1 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
CDC20
cell division cycle 20
total:6
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Santa Cruz Biotechnology monoclonal anti-p55CDC antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
CDCA8
cell division cycle associated 8
total:4
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
ProteinTech polyclonal anti-Borealin was used to perform immunocytochemistry in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
CENP C
centromere protein C
total:1
Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. 2007 to the paper
Bill Earnshaw (Institute of Molecular and Cell Biology, Edinburgh, Scotland) rabbit polyclonal anti-CENP-C antibody was used in chromatin immunoprecipitation to study co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres
CENPA
centromere protein A
total:7
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. 2009 to the paper
MBL International mouse anti-CenpA antibody (1:1,000) was used in immunocytochemistry in order to study the hSpindly-mediated dynein functions and the role of KT dynein in spindle orientation. more
CENPE
centromere protein E
total:3
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Abcam monoclonal anti-CENP-E antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
CENPF
centromere protein F
total:4
Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer. 2008 to the paper
Abcam CENP-F antibody (ab90, 1/200 dilution) was used to perform immunohistochemistry in order to clarify that high CENP-F expression was the prognostic indicator of primary breast cancer. more
CENPH
centromere protein H
total:2
Prognostic relevance of Centromere protein H expression in esophageal carcinoma. 2008 to the paper
Bethyl Laboratories anti-CENP-H rabbit polyclonal antibody was used in western blot in order to clarify the expression of Centromere protein H (CENP-H) in esophageal carcinoma and its correlation with clinicopathological features more
CENPT
centromere protein T
total:1
Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. 2011 to the paper
Bethyl anti-CENP-T antibody was used to perform western blot and immunofluorescence in order to study the effect of CENP-T and -W in the cell cycle.
CKAP5
cytoskeleton associated protein 5
CLASP1
cytoplasmic linker associated protein 1
total:1
Effects of a chemical chaperone on genetic mutations in alpha-galactosidase A in Korean patients with Fabry disease. 2009 to the paper
Santa Cruz GFP monoclonal antibody was used in western blot in order to study the role of DGJ for enhancing GLA enzyme activity and protein expression in the atypical form of Fabry disease.
cyclin B1
total:64
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Thermo Fisher Scientific anti-cyclin B1 monoclonal antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
DSN1
DSN1 component of MIS12 kinetochore complex
ELYS
AT-hook containing transcription factor 1
ERCC6L
ERCC excision repair 6 like, spindle assembly checkpoint helicase
HDAC8
histone deacetylase 8
total:3
A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression. 2009 to the paper
Santa Cruz Biotechnology anti-HDAC8 antibody was used to perform western blot in order to study the role of histone deacetylase (HDAC) in the regulation of HIV-1 expression. more
INCENP
inner centromere protein
total:6
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 to the paper
Santa Cruz Biotechnology anti-inner centromeric protein antibody was used in immunocytochemistry in order to investigate the spatial and temporal coordination of subunit-Mps one binding (Mob) 1 and chromosomal passenger complex during mitosis. more
KIF2C
kinesin family member 2C
total:1
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. 2010 to the paper
Abnova mouse monoclonal anti-MCAK antibody was used to carry out immunoblotting assays in order to investigate the mechanism for Haspin-mediated histone H3 thr-3 phosphorylation regulating chromosomal passenger complex accumulation at centromeres.
MAD1L1
mitotic arrest deficient 1 like 1
total:2
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. 2008 to the paper
Santa Cruz Biotechnology anti-mad1 antibody was used for western blot in order to investigate the roles of PI3K/Akt and MAPK pathways in the regulation of Myc-mediated transcription more
Mad2
mitotic arrest deficient 2 like 1
total:11
Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors. 2010 to the paper
Immuquest anti-MAD2 antibody was used in western blot in order to investigate the different expression levels of spindle proteins in the testicular germ cell tumors. more
MAPRE1
microtubule associated protein RP/EB family member 1
total:3
Mammalian end binding proteins control persistent microtubule growth. 2009 to the paper
BD Biosciences anti-EB1 mouse monoclonal antibody was used in immunohistochemistry and western blot in order to show that persistent microtubule growth can be regulated by end binding proteins in mammal. more
NDC80
NDC80 kinetochore complex component
total:4
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 to the paper
Abcam anti-Hec1 antibody was used in immunocytochemistry in order to investigate the spatial and temporal coordination of subunit-Mps one binding (Mob) 1 and chromosomal passenger complex during mitosis. more
NDE1
nudE neurodevelopment protein 1
total:1
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. 2009 to the paper
Proteintech Group rabbit anti-Nde1 antibody (1:1,000) was used in immunocytochemistry in order to study the hSpindly-mediated dynein functions and the role of KT dynein in spindle orientation.
NSL1
NSL1 component of MIS12 kinetochore complex
NUDC
nuclear distribution C, dynein complex regulator
total:1
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe. 2010 to the paper
Santa Cruz anti-NUDC antibody was used to perform western blot in order to study the role of non-directed activity-based protein profiling plays in the identification of enzymes that are either predominantly or exclusively labeled in living cells.
NUDEL
nudE neurodevelopment protein 1 like 1
total:1
Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport.. 2009 to the paper
Sigma-Aldrich anit-VSVG antibody was used to perform immunocytochemistry to study the role of cPLA2a in the formation of intercisternal tubular continuities and transport through the Golgi complex.
NUF2
NUF2 component of NDC80 kinetochore complex
NUP133
nucleoporin 133
total:1
The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis. 2009 to the paper
Covance anti-nucleoporin antibody was used to perform western blot in order to study the roles of Nup153 plays in mitosis.
PAFAH1B1
platelet activating factor acetylhydrolase 1b regulatory subunit 1
total:6
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. 2010 to the paper
Sigma anti-LIS1 antibody was uesd to perform western blot in order to study the regulation of the LIS1/dynein pathway by NudC-like protein 2 via stabilizing LIS1 with Hsp90. more
Plk1
polo like kinase 1
total:29
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Plk1 antibody was used to perform immunoprecipitation in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
PP2AC
protein phosphatase 2 catalytic subunit alpha
total:20
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. 2008 to the paper
Upstate monoclonal anti-PP2Ac antibody was used in western blot in order to study the abnormal hyperphosphorylation of tau and its possible causes in adult DS brains more
PPP1CC
protein phosphatase 1 catalytic subunit gamma
total:2
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. 2007 to the paper
Santa Cruz Biotechnology goat polyclonal PP1 gamma C antibody was used in western blot to study the regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma more
PPP2R1A
protein phosphatase 2 scaffold subunit Aalpha
total:7
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. 2008 to the paper
Upstate polyclonal anti-PP2A-A antibody was used in western blot in order to study the abnormal hyperphosphorylation of tau and its possible causes in adult DS brains more
PPP2R1B
protein phosphatase 2 scaffold subunit Abeta
total:2
SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. 2007 to the paper
Sigma-Aldrich polyclonal antibody to the PP2APR65 subunit was used to perform western blot in order to investigate the functions of salt-inducible kinase-1. more
RAD21
RAD21 cohesin complex component
total:2
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Novus anti-human Rad21 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
RANBP2
RAN binding protein 2
total:4
Nitric oxide destabilizes Pias3 and regulates sumoylation. 2007 to the paper
Santa Cruz polyclonal anti-RanBP2 was used to perform western blot in order to show that global sumoylation and Pias3 stabilization could be regulated by nitric oxide. more
ROD
kinetochore associated 1
total:1
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. 2009 to the paper
Abnova mouse anti-Rod antibody (1:100) was used in immunocytochemistry in order to study the hSpindly-mediated dynein functions and the role of KT dynein in spindle orientation.
RPS27
ribosomal protein S27
total:3
Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. 2009 to the paper
Millipore anti-Mps1 antibody was used to perform immunohistochemistry in order to study the regulation of Mps1 phosphorylation in kinetochore targeting and spindle checkpoint signaling. more
SEC13
SEC13 homolog, nuclear pore and COPII coat complex component
SGO1
shugoshin 1
total:1
Mutational inactivation of STAG2 causes aneuploidy in human cancer. 2011 to the paper
Novus Biologicals anti-SGOL1 was used to perform western blot in order to show that aneuploidy in tumor cells is associated with STAG2 inactivation.
SKA1
spindle and kinetochore associated complex subunit 1
SKA2
spindle and kinetochore associated complex subunit 2
Smc1
structural maintenance of chromosomes 1A
total:14
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. 2011 to the paper
Bethyl anti-SMC1 was used to perform western blot in order to show that RHINO is important for ATR activation during DNA damage responses. more
SMC3
structural maintenance of chromosomes 3
SPC24
SPC24 component of NDC80 kinetochore complex
SPC25
SPC25 component of NDC80 kinetochore complex
SPDL1
spindle apparatus coiled-coil protein 1
STAG1
stromal antigen 1
total:2
Mutational inactivation of STAG2 causes aneuploidy in human cancer. 2011 to the paper
Santa Cruz anti-STAG1 was used to perform western blot in order to show that aneuploidy in tumor cells is associated with STAG2 inactivation. more
STAG2
stromal antigen 2
total:1
Mutational inactivation of STAG2 causes aneuploidy in human cancer. 2011 to the paper
Santa Cruz anti-STAG2 was used to perform western blot and immunohistochemistry in order to show that aneuploidy in tumor cells is associated with STAG2 inactivation.
survivin
baculoviral IAP repeat containing 5
total:33
Two histone marks establish the inner centromere and chromosome bi-orientation. 2010 to the paper
Novus Biologicals rabbit polyclonal anti-Survivin antibody was used to carry out western blot analysis in order to investigate the mechanism for how inner centromere is established and how the CPC is targeted to this site. more
TAOK1
TAO kinase 1
total:2
TAO kinases mediate activation of p38 in response to DNA damage. 2007 to the paper
BD Biosciences mouse anti-TAO1 antibody was used in western blot to study the role of TAO kinases in DNA damage response. more
TD 60
regulator of chromosome condensation 2
XPO1
exportin 1
total:7
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. 2009 to the paper
Santa Cruz Biotechnology CRM-1 antibody was used for Western blotting in order to investigate the effect of LKB1 on nucleocytoplasmic transport. more
ZW10
zw10 kinetochore protein
total:2
A mammalian NudC-like protein essential for dynein stability and cell viability. 2006 to the paper
Antibodies anti-CREST antibody was used in western blot in order to demonstrate that NudC-like protein (NudCL) plays an essential role in mitosis and contributes to stabilization of the dynein complex. more